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Published in: European Journal of Plastic Surgery 6/2023

10-07-2023 | Lymphedema | Review

Global impact of lymphedema on quality of life and society

Authors: Katrina M. Jaszkul, Kaveh Farrokhi, Valera Castanov, Kathryn Minkhorst, Erica Ai Li, Lauren Sano, Stephanie Kim, Stephen Keelan, Khalifa Al-Ghanim, Andrew Simpson

Published in: European Journal of Plastic Surgery | Issue 6/2023

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Abstract

Lymphedema is a chronic disorder of the lymphatic system characterized by the accumulation of interstitial fluid in tissues. It affects millions of individuals worldwide, resulting in significant disability and morbidity. Despite its prevalence, it is often an underappreciated clinical entity. In this narrative review, we critically examined and synthesized currently available peer-reviewed literature on the global epidemiology, pathophysiology, and societal burden of lymphedema. Most patients have a secondary cause of lymphedema, such as lymphatic filariasis, mostly prevalent in Asia, South America, and Africa. A smaller proportion of lymphedema is secondary to malignancy or post-oncological treatment. Breast cancer, prostate cancer, cervical cancer, and melanoma are most often associated with causing lymphedema secondary to nodal involvement. Several tools have been developed to assess the effect of lymphedema on quality of life which can cause personal and financial impacts on those affected. Lymphedema is a globally prevalent but underappreciated disease in the developed and developing world. Lymphedema causes a significant burden on quality of life and financial stability to patients. Therefore, awareness among the healthcare team and patient education on prevention and minimizing morbidity are crucial. 
Level of Evidence: Not gradable.
Literature
16.
go back to reference Committee Executive (2016) The diagnosis and treatment of peripheral lymphedema: 2016 consensus document of the International Society of Lymphology. Lymphology 49(4):170–184 Committee Executive (2016) The diagnosis and treatment of peripheral lymphedema: 2016 consensus document of the International Society of Lymphology. Lymphology 49(4):170–184
17.
go back to reference Sleigh BC, Manna B (2021) Lymphedema. StatPearls Sleigh BC, Manna B (2021) Lymphedema. StatPearls
23.
go back to reference Földi M, Földi E, Strößenreuther C, Kubik S (2012) Földi’s textbook of lymphology: for physicians and lymphedema therapists. Elsevier Health Sciences Földi M, Földi E, Strößenreuther C, Kubik S (2012) Földi’s textbook of lymphology: for physicians and lymphedema therapists. Elsevier Health Sciences
41.
go back to reference Yimer M, Hailu T, Mulu W, Abera B (2015) Epidemiology of elephantiasis with special emphasis on podoconiosis in Ethiopia: A literature review. J Vector Borne Dis 52(2):111–115PubMed Yimer M, Hailu T, Mulu W, Abera B (2015) Epidemiology of elephantiasis with special emphasis on podoconiosis in Ethiopia: A literature review. J Vector Borne Dis 52(2):111–115PubMed
62.
go back to reference Bittar S, Simman R, Lurie F (2020) Lymphedema: a practical approach and clinical update. Wounds 32(3):86–92PubMed Bittar S, Simman R, Lurie F (2020) Lymphedema: a practical approach and clinical update. Wounds 32(3):86–92PubMed
66.
go back to reference International Society of Lymphology (2013) The diagnosis and treatment of peripheral lymphedema: 2013 Consensus document of the international society of lymphology. Lymphology 46:1–11 International Society of Lymphology (2013) The diagnosis and treatment of peripheral lymphedema: 2013 Consensus document of the international society of lymphology. Lymphology 46:1–11
67.
go back to reference Vercruyce M, Debbaut C, Segers P (2021) The biochemical properties of the lymphatic system and the changes in lymphedema. Ghent University, Ghent Vercruyce M, Debbaut C, Segers P (2021) The biochemical properties of the lymphatic system and the changes in lymphedema. Ghent University, Ghent
71.
go back to reference Lahtinen T, Seppälä J, Viren T, Johansson K (2015) Experimental and analytical comparisons of tissue dielectric constant (TDC) and bioimpedance spectroscopy (BIS) in assessment of early arm lymphedema in breast cancer patients after axillary surgery and radiotherapy. Lymphat Res Biol 13(3):176–185. https://doi.org/10.1089/lrb.2015.0019CrossRefPubMed Lahtinen T, Seppälä J, Viren T, Johansson K (2015) Experimental and analytical comparisons of tissue dielectric constant (TDC) and bioimpedance spectroscopy (BIS) in assessment of early arm lymphedema in breast cancer patients after axillary surgery and radiotherapy. Lymphat Res Biol 13(3):176–185. https://​doi.​org/​10.​1089/​lrb.​2015.​0019CrossRefPubMed
84.
go back to reference Zimmermann A, Wozniewski M, Szklarska A, Lipowicz A, Szuba A (2012) Efficacy of manual lymphatic drainage in preventing secondary lymphedema after breast cancer surgery. Lymphology 45(3):103–112PubMed Zimmermann A, Wozniewski M, Szklarska A, Lipowicz A, Szuba A (2012) Efficacy of manual lymphatic drainage in preventing secondary lymphedema after breast cancer surgery. Lymphology 45(3):103–112PubMed
101.
go back to reference Keeley V, Crooks S, Locke J, Veigas D, Riches K, Hilliam R (2010) A quality of life measure for limb lymphoedema (LYMQOL). J Lymphoedema 5:26–37 Keeley V, Crooks S, Locke J, Veigas D, Riches K, Hilliam R (2010) A quality of life measure for limb lymphoedema (LYMQOL). J Lymphoedema 5:26–37
112.
go back to reference Obindo J et al (2017) Prevalence of depression and associated clinical and socio-demographic factors in people living with lymphatic filariasis in Plateau State, Nigeria. PLoS Negl Trop Dis 11(6):e0005567 Obindo J et al (2017) Prevalence of depression and associated clinical and socio-demographic factors in people living with lymphatic filariasis in Plateau State, Nigeria. PLoS Negl Trop Dis 11(6):e0005567
148.
go back to reference Stout NL et al (2013) A systematic review of care delivery models and economic analyses in lymphedema: Health policy impact (2004–2011). Lymphology 46(1):27–41PubMed Stout NL et al (2013) A systematic review of care delivery models and economic analyses in lymphedema: Health policy impact (2004–2011). Lymphology 46(1):27–41PubMed
Metadata
Title
Global impact of lymphedema on quality of life and society
Authors
Katrina M. Jaszkul
Kaveh Farrokhi
Valera Castanov
Kathryn Minkhorst
Erica Ai Li
Lauren Sano
Stephanie Kim
Stephen Keelan
Khalifa Al-Ghanim
Andrew Simpson
Publication date
10-07-2023
Publisher
Springer Berlin Heidelberg
Keyword
Lymphedema
Published in
European Journal of Plastic Surgery / Issue 6/2023
Print ISSN: 0930-343X
Electronic ISSN: 1435-0130
DOI
https://doi.org/10.1007/s00238-023-02094-w

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