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World Journal of Surgical Oncology
Published in: World Journal of Surgical Oncology 1/2016

Open Access 01-12-2016 | Research

Lymph node ratio as a prognostic factor in patients with pathological N2 non-small cell lung cancer

Authors: Masaya Tamura, Isao Matsumoto, Daisuke Saito, Shuhei Yoshida, Munehisa Takata, Hirofumi Takemura

Published in: World Journal of Surgical Oncology | Issue 1/2016

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Abstract

Background

The aim of this study was to investigate whether the lymph node ratio (LNR) was associated with the prognosis of patients, who underwent surgery for pathological N2 non-small cell lung cancer (NSCLC).

Methods

A total of 182 patients were diagnosed with pathological N2 disease and underwent complete resection surgeries with systematic lymphadenectomies. We counted the number of positives and removed lymph nodes to calculate a ratio between them (LNR). We also investigated the association between skip mediastinal lymph node metastasis and survival.

Results

Univariate analysis of survival in patients with N2 NSCLC showed that the T factor, clinical N factor, and LNR were significant prognostic factors. Multivariate analyses showed that the clinical N stage and LNR were significant independent prognostic factors for patients with pathological N2 NSCLC. Patients with a clinical lymph node status of 0 (cN0) and LNR ≤0.22 showed a significantly higher survival rate than patients with a cN1-2 and LNR ≥0.22 and 5-year survival rates were 47.1 and 10.3%, respectively (p < 0.0001).

Conclusions

LNR is an important prognostic factor for poor outcome following surgery in patients with N2 disease. The combination of the LNR and cN status provides a valuable prognostic tool.
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Metadata
Title
Lymph node ratio as a prognostic factor in patients with pathological N2 non-small cell lung cancer
Authors
Masaya Tamura
Isao Matsumoto
Daisuke Saito
Shuhei Yoshida
Munehisa Takata
Hirofumi Takemura
Publication date
01-12-2016
Publisher
BioMed Central
Published in
World Journal of Surgical Oncology / Issue 1/2016
Electronic ISSN: 1477-7819
DOI
https://doi.org/10.1186/s12957-016-1048-5

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