Published in:
01-12-2007 | Case Report
Low-dose oral methotrexate for the management of childhood Cogan’s syndrome: a case report
Authors:
Yuzaburo Inoue, Takuya Tomemori, Shuichi Suzuki, Takayasu Arima, Minako Tomiita, Naoki Shimojo, Yoichi Kohno
Published in:
Clinical Rheumatology
|
Issue 12/2007
Login to get access
Abstract
Cogan’s syndrome is a rare inflammatory disease characterized by nonsyphilitic ocular interstitial keratitis associated with hearing loss and vestibular impairment. Although systemic corticosteroids are usually used as the standard therapy, hearing ability in most cases gradually deteriorates. We, herein, describe a patient with childhood Cogan’s syndrome who was treated with low-dose oral methotrexate, which successfully helped to taper the doses of the systemic corticosteroids. The serum levels of the complements were good markers for the disease activity in this patient.