Published in:
01-04-2007 | Case Report
Low-dose epoprostenol improved pulmonary hypertension in a patient with systemic lupus erythematosus
Authors:
Yoshihiro Matsukawa, Kohmei Igei, Takamasa Nozaki, Takafumi Ohki, Takako Shimizu, Noboru Kitamura, Ko Mitamura, Masami Takei, Yuji Kasamaki, Shigemasa Sawada
Published in:
Clinical Rheumatology
|
Issue 4/2007
Login to get access
Abstract
A 43-year-old Japanese woman was referred to our hospital in 1997 because of Raynaud’s phenomenon. Systemic lupus erythematosus was diagnosed on the basis of the presence of antinuclear antibody (1:1,280), anti-DNA antibody (1:640), anti-Sm antibody, antiphospholipid antibody, lymphopenia, and proteinuria. She developed pulmonary fibrosis in 1999 and pulmonary hypertension in 2001. In October 2002, a 24-hr continuous infusion of epoprostenol was started. Dyspnea, Raynaud’s phenomenon, and pulmonary hypertension improved with low-dose epoprostenol (3.0 to 4.0 ng kg−1 min−1). The patient could not tolerate larger doses of epoprostenol so 4.0 ng kg−1 min−1 was selected as the maintenance dose. The clinical course was uneventful at this dosage. It appears that pulmonary hypertension can be controlled with low-dose epoprostenol such as 3.0 to 4.0 ng kg−1 min−1 in some rheumatic patients.