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01-08-2016 | Original Paper

Longitudinal Changes in Cerebellar and Thalamic Spontaneous Neuronal Activity After Wide-Awake Surgery of Brain Tumors: a Resting-State fMRI Study

Authors: Anthony Boyer, Jérémy Deverdun, Hugues Duffau, Emmanuelle Le Bars, François Molino, Nicolas Menjot de Champfleur, François Bonnetblanc

Published in: The Cerebellum | Issue 4/2016

Abstract

Hypometabolism has been observed in the contralesional cerebellar hemisphere after various supratentorial cortical lesions. It is unknown whether the consequences of the dee- and deafferentation subsequent to wide-awake surgery for brain diffuse low-grade glioma can be assessed within remote and unresected subcortical structures such as the cerebellum or thalamus. To answer this question, we have conducted several regional analyses. More specifically, we have performed amplitude of low-frequency fluctuations (neuronal activity magnitude) and regional homogeneity (local temporal correlations) analyses on resting state functional magnetic resonance imaging (rs-fMRI) data and at different time points, before and after surgery. Our main results demonstrated that it is possible to evaluate subtle subcortical changes using these tools dedicated to the analysis of rs-fMRI data. The observed variations of spontaneous neuronal activity were particularly significant within the cerebellum which showed altered regional homogeneity and neuronal activity intensity in very different, specialized and non-overlapping subregions, in accordance to its neuro-anatomo-functional topography. These variations were moreover observed in the immediate postoperative period and recovered after 3 months.

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Title: Longitudinal Changes in Cerebellar and Thalamic Spontaneous Neuronal Activity After Wide-Awake Surgery of Brain Tumors: a Resting-State fMRI Study
Authors: Anthony Boyer
Jérémy Deverdun
Hugues Duffau
Emmanuelle Le Bars
François Molino
Nicolas Menjot de Champfleur
François Bonnetblanc
Publication date: 01-08-2016
Publisher: Springer US
Published in: The Cerebellum / Issue 4/2016
Print ISSN: 1473-4222
Electronic ISSN: 1473-4230
DOI: https://doi.org/10.1007/s12311-015-0709-1

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Longitudinal Changes in Cerebellar and Thalamic Spontaneous Neuronal Activity After Wide-Awake Surgery of Brain Tumors: a Resting-State fMRI Study

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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