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Open Access 01-12-2024 | Research

Longitudinal association of grip strength with cardiovascular and all-cause mortality in older urban Lithuanian population

Authors: Lolita Sileikiene, Abdonas Tamosiunas, Dalia Luksiene, Ricardas Radisauskas, Daina Kranciukaite-Butylkiniene, Martin Bobak

Published in: BMC Public Health | Issue 1/2024

Abstract

Background

Ageing populations experience greater risks associated with health and survival. It increases the relevance of identifying variables associated with mortality. Grip strength (GS) has been identified as an important biomarker for all cause and cardiovascular mortality, however, its prognostic value has not been studied in Lithuania. The aim of the present study is to evaluate the relationship of GS to vital status in a representative sample of the Lithuanian 45–72-year-old urban population during the period of 12 years of follow-up and to explore associations of GS with all-cause mortality and mortality from cardiovascular diseases (CVD).

Methods

Within the framework of the international study Health, Alcohol and Psychosocial Factors in Eastern Europe (HAPIEE) 7,115 men and women 45–72 years of age were examined in the baseline survey (2006 to 2008). Data from the Official Lithuanian Mortality Register were used to evaluate CVD and all-cause mortality from follow-up till 2020. Cox proportional hazards regression was used, and four models for all-cause and CVD mortality were assessed.

Results

The mean GS was significantly higher among survivors’ men and women as compared to individuals deceased from CVD and other causes of death. In survivor men and women groups, minimal values of GS in all terciles were higher as compared to all three deceased groups. In both men and women groups, the lowest GS (1st tercile) was associated with a significantly higher risk of all-cause and CVD mortality as compared to the highest levels of GS (3rd tercile) in three Cox regression models. In both men and women were found to have a 1.34- and 1.35-fold higher risk of all-cause mortality, respectively, at lower GS, but no significant difference in the risk of CVD mortality. When GS was treated in all models as decrement per 1 kg and decrement per 1 SD, in both men and women, the risk of all-cause mortality significantly increased with decreasing of GS.

Conclusions

The mean GS was significantly higher among survivors’ men and women as compared to deceased from CVD and other causes of death. Risk of all-cause mortality significantly increased with decreasing of GS.

United Nations, Department of Economic and Social Affairs, Population Division. (2019). World Population Ageing 2019: Highlights (ST/ESA/SER.A/430).

Ageing Europe — looking at the lives of older people in the EU. 2020 edition, Eurostat. https://ec.europa.eu/eurostat/documents/3217494/11478057/KS-02-20-655-EN-N.pdf/9b09606c-d4e8-4c33-63d2-3b20d5c19c91?t=1604055531000. Accessed 4 Jul 2023.

Kalache A, Gatti A. Active ageing: a policy framework. Adv Gerontol. 2003;11:7–18. PMID: 12820516.PubMed

Decade of healthy ageing: baseline report. Licence: CC BY-NC-SA 3.0 IGO. Geneva: World Health Organization; 2020.

Cruz-Jentoft AJ, Baeyens JP, Bauer JM, Boirie Y, Cederholm T, Landi F, et al. European Working Group on Sarcopenia in Older People. Sarcopenia: European consensus on definition and diagnosis: report of the European Working Group on Sarcopenia in Older people. Age Ageing. 2010;39(4):412–23. https://doi.org/10.1093/ageing/afq034CrossRefPubMedPubMedCentral

Cooper R, Kuh D, Hardy R. Mortality Review Group; FALCon and HALCyon Study teams. Objectively measured physical capability levels and mortality: systematic review and meta-analysis. BMJ. 2010;341:c4467. https://doi.org/10.1136/bmj.c4467CrossRefPubMedPubMedCentral

Sasaki H, Kasagi F, Yamada M, Fujita S. Grip strength predicts cause-specific mortality in middle-aged and elderly persons. Am J Med. 2007;120(4):337–42. https://doi.org/10.1016/j.amjmed.2006.04.018CrossRefPubMed

Bohannon RW. Muscle strength: clinical and prognostic value of hand-grip dynamometry. Curr Opin Clin Nutr Metab Care. 2015;18(5):465–70. https://doi.org/10.1097/MCO.0000000000000202CrossRefPubMed

Strimbu K, Tavel JA. What are biomarkers? Curr Opin HIV AIDS. 2010; 5(6): 463–6. https://doi.org/10.1097/COH.0b013e32833ed177

10.

World Health Organization. World report on ageing and health. World Health Organization. 2015. https://apps.who.int/iris/handle/10665/186463. Accessed 4 Jul 2023.

11.

Bohannon RW. Grip strength: an indispensable biomarker for older adults. Clin Interv Aging. 2019;14:1681–91. https://doi.org/10.2147/CIA.S194543CrossRefPubMedPubMedCentral

12.

Núñez-Cortés R, Cruz BDP, Gallardo-Gómez D, Calatayud J, Cruz-Montecinos C, López-Gil JF, et al. Handgrip strength measurement protocols for all-cause and cause-specific mortality outcomes in more than 3 million participants: a systematic review and meta-regression analysis. Clin Nutr. 2022;41(11):2473–89. https://doi.org/10.1016/j.clnu.2022.09.006. Epub 2022 Sep 16.CrossRefPubMed

13.

Dodds RM, Kuh D, Sayer AA, Cooper R. Can measures of physical performance in mid-life improve the clinical prediction of disability in early old age? Findings from a British birth cohort study. Exp Gerontol. 2018;110:118–24. Epub 2018 Jun 7.CrossRefPubMed

14.

Lopez-Jaramillo P, Lopez-Lopez JP, Tole MC, Cohen DD. Muscular strength in risk factors for Cardiovascular Disease and Mortality: a narrative review. Anatol J Cardiol. 2022;26(8):598–607. https://doi.org/10.5152/AnatolJCardiol.2022.1586CrossRefPubMedPubMedCentral

15.

Ho FKW, Celis-Morales CA, Petermann-Rocha F, Sillars A, Welsh P, Welsh C, et al. The association of grip strength with health outcomes does not differ if grip strength is used in absolute or relative terms: a prospective cohort study. Age Ageing. 2019;48(5):684–91. https://doi.org/10.1093/ageing/afz068CrossRefPubMed

16.

Leong DP, Teo KK, Rangarajan S, Lopez-Jaramillo P, Avezum A Jr, Orlandini A, et al. Prospective Urban Rural Epidemiology (PURE) study investigators. Prognostic value of grip strength: findings from the prospective Urban Rural Epidemiology (PURE) study. Lancet. 2015;386(9990):266–73. https://doi.org/10.1016/S0140-6736(14)62000-6. Epub 2015 May 13.CrossRefPubMed

17.

López-Bueno R, Andersen LL, Koyanagi A, Núñez-Cortés R, Calatayud J, Casaña J, et al. Thresholds of handgrip strength for all-cause, cancer, and cardiovascular mortality: a systematic review with dose-response meta-analysis. Ageing Res Rev. 2022;82:101778. https://doi.org/10.1016/j.arr.2022.101778. Epub 2022 Nov 1.CrossRefPubMed

18.

Laukkanen JA, Voutilainen A, Kurl S, Araujo CGS, Jae SY, Kunutsor SK. Handgrip strength is inversely associated with fatal cardiovascular and all-cause mortality events. Ann Med. 2020;52(3–4):109–19. Epub 2020 Apr 9.CrossRefPubMedPubMedCentral

19.

WHO Mortality Database. Available: https://www.who.int/data/data-collection-tools/who-mortality-database. Accessed 19 Dec 2023.

20.

Peasey A, Bobak M, Kubinova R, Malyutina S, Pajak A, Tamosiunas A, et al. Determinants of cardiovascular disease and other non-communicable diseases in Central and Eastern Europe: rationale and design of the HAPIEE study. BMC Public Health. 2006;6:255. https://doi.org/10.1186/1471-2458-6-255CrossRefPubMedPubMedCentral

21.

Sapranaviciute-Zabazlajeva L, Luksiene D, Virviciute D, Bobak M, Tamosiunas A. Link between healthy lifestyle and psychological well-being in Lithuanian adults aged 45–72: a cross-sectional study. BMJ Open. 2017;7(4):e014240. https://doi.org/10.1136/bmjopen-2016-014240CrossRefPubMedPubMedCentral

22.

Luksiene D, Tamosiunas A, Virviciute D, Bernotiene G, Peasey A. Anthropometric trends and the risk of cardiovascular disease mortality in a Lithuanian urban population aged 45–64 years. Scand J Public Health. 2015;43(8):882–9. https://doi.org/10.1177/1403494815597582. Epub 2015 Aug 10.CrossRefPubMedPubMedCentral

23.

Tamosiunas A, Baceviciene M, Reklaitiene R, Radisauskas R, Jureniene K, Azaraviciene A, et al. Cardiovascular risk factors and cognitive function in middle aged and elderly Lithuanian urban population: results from the HAPIEE study. BMC Neurol. 2012;12:149. https://doi.org/10.1186/1471-2377-12-149CrossRefPubMedPubMedCentral

24.

Carpenter JS, Andrykowski MA, Wilson J, Hall LA, Rayens MK, Sachs B, et al. Psychometrics for two short forms of the Center for Epidemiologic Studies-Depression Scale. Issues Ment Health Nurs. 1998;19(5):481–94. https://doi.org/10.1080/016128498248917CrossRefPubMed

25.

Marmot M, Banks J, Blundell R, Lessof C, Nazroo J. Health, wealth and lifestyles of the older population in England. The 2002 English Longitudinal Study of Ageing. London: Institute of Fiscal Studies; 2003.

26.

Welsh KA, Butters N, Mohs RC, Beekly D, Edland S, Fillenbaum G, et al. The Consortium to establish a Registry for Alzheimer’s Disease (CERAD). Part V. A normative study of the neuropsychological battery. Neurology. 1994;44(4):609–14. https://doi.org/10.1212/wnl.44.4.609CrossRefPubMed

27.

Kim GR, Netuveli G, Blane D, Peasey A, Malyutina S, Simonova G, et al. Psychometric properties and confirmatory factor analysis of the CASP-19, a measure of quality of life in early old age: the HAPIEE study. Aging Ment Health. 2015;19(7):595–609. Epub 2014 Jul 25.CrossRefPubMed

28.

Norkus A, Ostrauskas R, Sulcaite R, Baranauskiene E, Baliutaviciene D. Classification and diagnosis of diabetes mellitus (methodology recommendations). Lith Endocrinol. 2000;3:234–41.

29.

Prineas RJ, Crow RS, Blackburn HW. The Minnesota Code Manual of Electrocardiographic Findings: Standards and Procedures for Measurement and Classification;, Wright J. Boston, MA, USA, 1982; p. 229.

30.

Rose GA, Blackburn H, Gillum RF. Cardiovascular Survey Methods; (Monograph Series); World Health Organization: Geneva, Switzerland, 1982; p. 56.

31.

Tamosiunas A, Sapranaviciute-Zabazlajeva L, Luksiene D, Virviciute D, Bobak M. Cognitive Function and Mortality: Results from Kaunas HAPIEE Study 2006–2017. Int J Environ Res Public Health. 2020; 17(7): 2397. https://doi.org/10.3390/ijerph17072397. PMID: 32244660.

32.

Tamosiunas A, Sapranaviciute-Zabazlajeva L, Luksiene D, Virviciute D, Peasey A. Psychological well-being and mortality: longitudinal findings from Lithuanian middle-aged and older adults study. Soc Psychiatry Psychiatr Epidemiol. 2019;54(7):803–11. https://doi.org/10.1007/s00127-019-01657-2. Epub 2019 Jan 9. PMID: 30627758; PMCID: PMC6656792.CrossRefPubMedPubMedCentral

33.

Lee SY. Handgrip Strength: An Irreplaceable Indicator of Muscle Function. Ann Rehabil Med. 2021; 45(3): 167–169. doi: 10.5535/arm.21106. Epub 2021 Jun 30. PMID: 34233405.

34.

Pinto Pereira SM, Garfield V, Farmaki AE, Tomlinson DJ, Norris T, Fatemifar G, et al. Adiposity and grip strength: a mendelian randomisation study in UK Biobank. BMC Med. 2022;20(1):201. https://doi.org/10.1186/s12916-022-02393-2CrossRefPubMedPubMedCentral

35.

Cruz-Jentoft AJ, Bahat G, Bauer J, Boirie Y, Bruyère O, Cederholm T et al. Writing Group for the European Working Group on Sarcopenia in Older People 2 (EWGSOP2), and the Extended Group for EWGSOP2. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing. 2019; 48(1): 16–31. https://doi.org/10.1093/ageing/afy169. Erratum in: Age Ageing. 2019;48(4):601.

36.

AuYeung TW, Leung J, Yu R, Lee JSW, Kwok T, Woo J. Decline and Peripheral redistribution of Fat Mass in Old Age - A four-year prospective study in 3018 older community-living adults. J Nutr Health Aging. 2018;22(7):847–53. https://doi.org/10.1007/s12603-018-1026-4CrossRefPubMed

37.

Wang YC, Bohannon RW, Li X, Sindhu B, Kapellusch J. Hand-grip strength: normative reference values and equations for individuals 18 to 85 years of Age Residing in the United States. J Orthop Sports Phys Ther. 2018;48(9):685–93. https://doi.org/10.2519/jospt.2018.7851. Epub 2018 May 23.CrossRefPubMed

38.

McGrath R, Vincent BM, Peterson MD, Jurivich DA, Dahl LJ, Hackney KJ, et al. Weakness May have a Causal Association with Early Mortality in Older americans: a matched cohort analysis. J Am Med Dir Assoc. 2020;21(5):621–e6262. https://doi.org/10.1016/j.jamda.2019.10.016. Epub 2019 Nov 27.CrossRefPubMed

39.

Huemer MT, Kluttig A, Fischer B, Ahrens W, Castell S, Ebert N, et al. Grip strength values and cut-off points based on over 200,000 adults of the German National Cohort - a comparison to the EWGSOP2 cut-off points. Age Ageing. 2023;52(1):afac324. https://doi.org/10.1093/ageing/afac324CrossRefPubMedPubMedCentral

40.

Kim SH, Kim T, Park JC, Kim YH. Usefulness of hand grip strength to estimate other physical fitness parameters in older adults. Sci Rep. 2022;12(1):17496. https://doi.org/10.1038/s41598-022-22477-6CrossRefPubMedPubMedCentral

41.

Ramsey KA, Rojer AGM, D’Andrea L, Otten RHJ, Heymans MW, Trappenburg MC, et al. The association of objectively measured physical activity and sedentary behaviour with skeletal muscle strength and muscle power in older adults: a systematic review and meta-analysis. Ageing Res Rev. 2021;67:101266. https://doi.org/10.1016/j.arr.2021.101266. Epub 2021 Feb 16.CrossRefPubMed

42.

Volaklis KA, Halle M, Meisinger C. Muscular strength as a strong predictor of mortality: A narrative review. Eur J Intern Med. 2015; 26(5): 303– 10. https://doi.org/10.1016/j.ejim.2015.04.013. Epub 2015 Apr 25.

43.

Whitney DG, Peterson MD. The Association between Differing grip strength measures and mortality and cerebrovascular event in older adults: National Health and Aging trends Study. Front Physiol. 2019;9:1871. https://doi.org/10.3389/fphys.2018.01871CrossRefPubMedPubMedCentral

44.

Soysal P, Hurst C, Demurtas J, Firth J, Howden R, Yang L, et al. Handgrip strength and health outcomes: Umbrella review of systematic reviews with meta-analyses of observational studies. J Sport Health Sci. 2021;10(3):290–5. Epub 2020 Jun 19.CrossRefPubMed

45.

Celis-Morales CA, Welsh P, Lyall DM, Steell L, Petermann F, Anderson J, et al. Associations of grip strength with cardiovascular, respiratory, and cancer outcomes and all cause mortality: prospective cohort study of half a million UK Biobank participants. BMJ. 2018;361:k1651. https://doi.org/10.1136/bmj.k1651CrossRefPubMedPubMedCentral

46.

García-Hermoso A, Cavero-Redondo I, Ramírez-Vélez R, Ruiz JR, Ortega FB, Lee DC, et al. Muscular strength as a predictor of all-cause mortality in an apparently healthy Population: a systematic review and Meta-analysis of data from approximately 2 million men and women. Arch Phys Med Rehabil. 2018;99(10):2100–e21135. https://doi.org/10.1016/j.apmr.2018.01.008. Epub 2018 Feb 7.CrossRefPubMed

47.

López-Bueno R, Andersen LL, Calatayud J, Casaña J, Grabovac I, Oberndorfer M, et al. Associations of handgrip strength with all-cause and cancer mortality in older adults: a prospective cohort study in 28 countries. Age Ageing. 2022;51(5):afac117. https://doi.org/10.1093/ageing/afac117CrossRefPubMedPubMedCentral

48.

Gubelmann C, Vollenweider P, Marques-Vidal P. No association between grip strength and cardiovascular risk: the CoLaus population-based study. Int J Cardiol. 2017;236:478–82. https://doi.org/10.1016/j.ijcard.2017.01.110. Epub 2017 Jan 21.CrossRefPubMed

49.

Hope AA, Hsieh SJ, Petti A, Hurtado-Sbordoni M, Verghese J, Gong MN. Assessing the usefulness and validity of Frailty markers in critically ill adults. Ann Am Thorac Soc. 2017;14(6):952–9. https://doi.org/10.1513/AnnalsATS.201607-538OCCrossRefPubMedPubMedCentral

50.

Lee L, Patel T, Costa A, Bryce E, Hillier LM, Slonim K, et al. Screening for frailty in primary care: accuracy of gait speed and hand-grip strength. Can Fam Physician. 2017;63(1):e51–7.PubMedPubMedCentral

51.

Lin CH, Liao CC, Huang CH, Tung YT, Chang HC, Hsu MC, et al. Proteomics Analysis to identify and characterize the biomarkers and physical activities of Non-frail and Frail older adults. Int J Med Sci. 2017;14(3):231–9. https://doi.org/10.7150/ijms.17627CrossRefPubMedPubMedCentral

52.

Nùñez-Lisboa M, Valero-Breton M, Dewolf AH. Unraveling age-related impairment of the neuromuscular system: exploring biomechanical and neurophysiological perspectives. Front Physiol. 2023;14:1194889. https://doi.org/10.3389/fphys.2023.1194889CrossRefPubMedPubMedCentral

53.

Tatangelo T, Muollo V, Ghiotto L, Schena F, Rossi AP. Exploring the association between handgrip, lower limb muscle strength, and physical function in older adults: a narrative review. Exp Gerontol. 2022;167:111902. https://doi.org/10.1016/j.exger.2022.111902CrossRefPubMed

54.

Muollo V, Tatangelo T, Ghiotto L, Cavedon V, Milanese C, Zamboni M, Schena F, Rossi AP. Is handgrip strength a marker of muscle and physical function of the lower limbs? Sex differences in older adults with obesity. Nutr Metab Cardiovasc Dis. 2022;32(9):2168–76. https://doi.org/10.1016/j.numecd.2022.06.018CrossRefPubMed

Title: Longitudinal association of grip strength with cardiovascular and all-cause mortality in older urban Lithuanian population
Authors: Lolita Sileikiene
Abdonas Tamosiunas
Dalia Luksiene
Ricardas Radisauskas
Daina Kranciukaite-Butylkiniene
Martin Bobak
Publication date: 01-12-2024
Publisher: BioMed Central
Published in: BMC Public Health / Issue 1/2024
Electronic ISSN: 1471-2458
DOI: https://doi.org/10.1186/s12889-024-18506-w

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Longitudinal association of grip strength with cardiovascular and all-cause mortality in older urban Lithuanian population

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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