Published in:
01-12-2015
Long-Term Survival After Lung Transplantation in Patients with Silicosis and Other Occupational Lung Disease
Published in: Lung | Issue 6/2015
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Background
Survival after lung transplantation (LTx) for patients with occupational lung disease (OLD) is not well studied.
Methods
The United Network for Organ Sharing (UNOS) database was queried from 2005 to 2013 to assess survival after LTx in patients with silicosis and non-silicotic OLD compared to non-OLD patients.
Results
Of 7273 adult LTx recipients, 7227 (24 with silicosis and 29 with non-silicotic OLD) were included in our univariate and Kaplan–Meier function analysis and 6370 for multivariate Cox models. Univariate Cox models did not identify survival differences in silicosis (HR 0.717; 95 % CI 0.358–1.435; p = 0.347) and non-silicotic OLDs (HR 0.934; 95 % CI 0.486–1.798; p = 0.839). Kaplan–Meier function analysis did not identify a survival disadvantage for either silicosis or non-silicotic OLD (log-rank test: χ
2 0.93, p = 0.627). Patients with non-silicotic OLD were at risk for worse survival for the first 2.5 years post-transplant; however, at the conclusion of the study, this group had the highest survival rate. Multivariate Cox models confirmed no increased risk for mortality for silicosis (HR 1.264; 95 % CI 0.631–2.534; p = 0.509) and non-silicotic OLD (HR 1.114; 95 % CI 0.578–2.147; p = 0.747).
Conclusion
Long-term survival for adult patients with silicosis and non-silicotic OLD after LTx is not significantly different compared to the general lung transplant population.