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Published in: Surgery Today 9/2018

01-09-2018 | Original Article

Long-term outcomes of surgery for choledochal cysts: a single-institution study focusing on follow-up and late complications

Authors: Motoi Mukai, Tatsuru Kaji, Ryuta Masuya, Koji Yamada, Koshiro Sugita, Tomoe Moriguchi, Shun Onishi, Waka Yamada, Takafumi Kawano, Seiro Machigashira, Kazuhiko Nakame, Hideo Takamatsu, Satoshi Ieiri

Published in: Surgery Today | Issue 9/2018

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Abstract

Purpose

The late postoperative complications of choledochal cyst (CC) surgery are serious and include intrahepatic stones and biliary carcinoma; therefore, long-term follow-up is crucial.

Methods

The subjects of this retrospective study were patients who underwent surgery for CC at Kagoshima University Hospital between April, 1984 and December, 2016. We analyzed the operative results, early and late postoperative complications, and postoperative follow-up rate.

Results

The study population comprised 110 CC patients (male/female: 33/77) with a median age at surgery of 4 years, 3 months (range 12 days–17 years). The patients underwent hepaticoduodenostomy (n = 1; 0.9%) or hepaticojejunostomy (n = 109; 99.1%). Late complications included intrahepatic bile duct (IHBD) dilatation (n = 1; 0.9%), IHBD stones (n = 3; 2.7%), and adhesive ileus (n = 4; 3.6%). There was no incidence of biliary carcinoma in this series. The rates of follow-up at our institute within 10 years of surgery and more than 20 years after surgery were 69.2% (18 of 26) and 14.5% (8 of 55), respectively.

Conclusions

The follow-up rate after definitive surgery declined with time. Late complications were observed within 20 years, but biliary carcinoma was not observed. The follow-up rate should be increased to detect late complications. Moreover, patient education on long-term follow up is essential to prevent life-threatening events after definitive surgery for CC.
Literature
1.
go back to reference Babbitt DP. Congenital choledochal cysts: new etiological concept based on anomalous relationships of the common bile duct and pancreatic bulb. Ann Radiol (Paris). 1969;12:231–40. Babbitt DP. Congenital choledochal cysts: new etiological concept based on anomalous relationships of the common bile duct and pancreatic bulb. Ann Radiol (Paris). 1969;12:231–40.
3.
go back to reference Edil BH, Cameron JL, Reddy S, Lum Y, Lipsett PA, Nathan H, et al. Choledochal cyst disease in children and adults: a 30-year single-institution experience. J Am Coll Surg. (2008);206:1000–5, (discussion 5–8). Edil BH, Cameron JL, Reddy S, Lum Y, Lipsett PA, Nathan H, et al. Choledochal cyst disease in children and adults: a 30-year single-institution experience. J Am Coll Surg. (2008);206:1000–5, (discussion 5–8).
4.
go back to reference Nagi B, Kochhar R, Bhasin D, Singh K. Endoscopic retrograde cholangiopancreatography in the evaluation of anomalous junction of the pancreaticobiliary duct and related disorders. Abdom Imaging. 2003;28:847 – 52.PubMedCrossRef Nagi B, Kochhar R, Bhasin D, Singh K. Endoscopic retrograde cholangiopancreatography in the evaluation of anomalous junction of the pancreaticobiliary duct and related disorders. Abdom Imaging. 2003;28:847 – 52.PubMedCrossRef
5.
go back to reference Ishibashi H, Shimada M, Kamisawa T, Fujii H, Hamada Y, Kubota M, et al. Japanese clinical practice guidelines for congenital biliary dilatation. J Hepat Pancreat Sci. 2017;24:1–16.CrossRef Ishibashi H, Shimada M, Kamisawa T, Fujii H, Hamada Y, Kubota M, et al. Japanese clinical practice guidelines for congenital biliary dilatation. J Hepat Pancreat Sci. 2017;24:1–16.CrossRef
6.
go back to reference She WH, Chung HY, Lan LC, Wong KK, Saing H, Tam PK. Management of choledochal cyst: 30 years of experience and results in a single center. J Pediatr Surg. 2009;44:2307–11.PubMedCrossRef She WH, Chung HY, Lan LC, Wong KK, Saing H, Tam PK. Management of choledochal cyst: 30 years of experience and results in a single center. J Pediatr Surg. 2009;44:2307–11.PubMedCrossRef
7.
go back to reference Todani T, Watanabe Y, Toki A, Morotomi Y. Classification of congenital biliary cystic disease: special reference to type Ic and IVA cysts with primary ductal stricture. J Hepat Pancreat Surg. 2003;10:340–4.CrossRef Todani T, Watanabe Y, Toki A, Morotomi Y. Classification of congenital biliary cystic disease: special reference to type Ic and IVA cysts with primary ductal stricture. J Hepat Pancreat Surg. 2003;10:340–4.CrossRef
8.
go back to reference Takeshita N, Ota T, Yamamoto M. Forty-year experience with flow-diversion surgery for patients with congenital choledochal cysts with pancreaticobiliary maljunction at a single institution. Ann Surg. 2011;254:1050–3.PubMedCrossRef Takeshita N, Ota T, Yamamoto M. Forty-year experience with flow-diversion surgery for patients with congenital choledochal cysts with pancreaticobiliary maljunction at a single institution. Ann Surg. 2011;254:1050–3.PubMedCrossRef
9.
go back to reference Todani T, Watanabe Y, Urushihara N, Noda T, Morotomi Y. Biliary complications after excisional procedure for choledochal cyst. J Pediatr Surg. 1995;30:478 – 81.PubMedCrossRef Todani T, Watanabe Y, Urushihara N, Noda T, Morotomi Y. Biliary complications after excisional procedure for choledochal cyst. J Pediatr Surg. 1995;30:478 – 81.PubMedCrossRef
10.
go back to reference Chijiiwa K, Tanaka M. Late complications after excisional operation in patients with choledochal cyst. J Am Coll Surg. 1994;179:139 – 44.PubMed Chijiiwa K, Tanaka M. Late complications after excisional operation in patients with choledochal cyst. J Am Coll Surg. 1994;179:139 – 44.PubMed
11.
go back to reference Saing H, Han H, Chan KL, Lam W, Chan FL, Cheng W, et al. Early and late results of excision of choledochal cysts. J Pediatr Surg. 1997;32:1563–6.PubMedCrossRef Saing H, Han H, Chan KL, Lam W, Chan FL, Cheng W, et al. Early and late results of excision of choledochal cysts. J Pediatr Surg. 1997;32:1563–6.PubMedCrossRef
12.
go back to reference Tsuchida Y, Takahashi A, Suzuki N, Kuroiwa M, Murai H, Toki F, et al. Development of intrahepatic biliary stones after excision of choledochal cysts. J Pediatr Surg. 2002;37:165–7.PubMedCrossRef Tsuchida Y, Takahashi A, Suzuki N, Kuroiwa M, Murai H, Toki F, et al. Development of intrahepatic biliary stones after excision of choledochal cysts. J Pediatr Surg. 2002;37:165–7.PubMedCrossRef
13.
go back to reference Ono S, Maeda K, Baba K, Usui Y, Tsuji Y, Yano T, et al. The efficacy of double-balloon enteroscopy for intrahepatic bile duct stones after Roux-en-Y hepaticojejunostomy for choledochal cysts. Pediatr Surg Int. 2013;29:1103–7.PubMedCrossRef Ono S, Maeda K, Baba K, Usui Y, Tsuji Y, Yano T, et al. The efficacy of double-balloon enteroscopy for intrahepatic bile duct stones after Roux-en-Y hepaticojejunostomy for choledochal cysts. Pediatr Surg Int. 2013;29:1103–7.PubMedCrossRef
14.
go back to reference Watanabe Y, Toki A, Todani T. Bile duct cancer developed after cyst excision for choledochal cyst. J Hepat Pancreat Surg. 1999;6:207 – 12.CrossRef Watanabe Y, Toki A, Todani T. Bile duct cancer developed after cyst excision for choledochal cyst. J Hepat Pancreat Surg. 1999;6:207 – 12.CrossRef
15.
go back to reference Kobayashi S, Asano T, Yamasaki M, Kenmochi T, Nakagohri T, Ochiai T. Risk of bile duct carcinogenesis after excision of extrahepatic bile ducts in pancreaticobiliary maljunction. Surgery. 1999;126:939 – 44.PubMedCrossRef Kobayashi S, Asano T, Yamasaki M, Kenmochi T, Nakagohri T, Ochiai T. Risk of bile duct carcinogenesis after excision of extrahepatic bile ducts in pancreaticobiliary maljunction. Surgery. 1999;126:939 – 44.PubMedCrossRef
17.
go back to reference Zheng X, Gu W, Xia H, Huang X, Liang B, Yang T, et al. Surgical treatment of type IV-A choledochal cyst in a single institution: children vs. adults. J Pediatr Surg. 2013;48:2061–6.PubMedCrossRef Zheng X, Gu W, Xia H, Huang X, Liang B, Yang T, et al. Surgical treatment of type IV-A choledochal cyst in a single institution: children vs. adults. J Pediatr Surg. 2013;48:2061–6.PubMedCrossRef
18.
go back to reference Ono S, Sakai K, Kimura O, Iwai N. Development of bile duct cancer in a 26-year-old man after resection of infantile choledochal cyst. J Pediatr Surg. 2008;43:E17-9.PubMedCrossRef Ono S, Sakai K, Kimura O, Iwai N. Development of bile duct cancer in a 26-year-old man after resection of infantile choledochal cyst. J Pediatr Surg. 2008;43:E17-9.PubMedCrossRef
19.
go back to reference Shimamura K, Kurosaki I, Sato D, Takano K, Yokoyama N, Sato Y, et al. Intrahepatic cholangiocarcinoma arising 34 years after excision of a type IV-A congenital choledochal cyst: report of a case. Surg Today. 2009;39:247 – 51.PubMedCrossRef Shimamura K, Kurosaki I, Sato D, Takano K, Yokoyama N, Sato Y, et al. Intrahepatic cholangiocarcinoma arising 34 years after excision of a type IV-A congenital choledochal cyst: report of a case. Surg Today. 2009;39:247 – 51.PubMedCrossRef
20.
go back to reference Ohashi T, Wakai T, Kubota M, Matsuda Y, Arai Y, Ohyama T, et al. Risk of subsequent biliary malignancy in patients undergoing cyst excision for congenital choledochal cysts. J Gastroenterol Hepatol. 2013;28:243–7.PubMedPubMedCentralCrossRef Ohashi T, Wakai T, Kubota M, Matsuda Y, Arai Y, Ohyama T, et al. Risk of subsequent biliary malignancy in patients undergoing cyst excision for congenital choledochal cysts. J Gastroenterol Hepatol. 2013;28:243–7.PubMedPubMedCentralCrossRef
21.
go back to reference Ng DW, Chiow AK, Poh WT, Tan SS. Metachronous cholangiocarcinoma 13 years post resection of choledochal cyst-is long-term follow-up useful?: a case study and review of the literature. Surg Case Rep. 2016;2:60.PubMedPubMedCentralCrossRef Ng DW, Chiow AK, Poh WT, Tan SS. Metachronous cholangiocarcinoma 13 years post resection of choledochal cyst-is long-term follow-up useful?: a case study and review of the literature. Surg Case Rep. 2016;2:60.PubMedPubMedCentralCrossRef
Metadata
Title
Long-term outcomes of surgery for choledochal cysts: a single-institution study focusing on follow-up and late complications
Authors
Motoi Mukai
Tatsuru Kaji
Ryuta Masuya
Koji Yamada
Koshiro Sugita
Tomoe Moriguchi
Shun Onishi
Waka Yamada
Takafumi Kawano
Seiro Machigashira
Kazuhiko Nakame
Hideo Takamatsu
Satoshi Ieiri
Publication date
01-09-2018
Publisher
Springer Singapore
Published in
Surgery Today / Issue 9/2018
Print ISSN: 0941-1291
Electronic ISSN: 1436-2813
DOI
https://doi.org/10.1007/s00595-018-1660-9

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