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01-08-2018 | Original Contributions

Long-term Metabolic Effects of Laparoscopic Sleeve Gastrectomy

Authors: Danila Capoccia, Federica Coccia, Gloria Guarisco, Moira Testa, Roberta Rendina, Francesca Abbatini, Gianfranco Silecchia, Frida Leonetti

Published in: Obesity Surgery | Issue 8/2018

Abstract

Objective

Obesity is one of the major health challenges throughout the world. The association between obesity and diabetes is well established because 90% of patients with type 2 diabetes mellitus (T2DM) show excess body weight. The aim of the study was to evaluate the effect of laparoscopic sleeve gastrectomy (LSG) on morbid obesity and type 2 diabetes (T2DM) in the long-term follow-up.

Methods

One hundred ninety-five obese patients, 78 with T2DM, were evaluated before and after LSG up to 10 years, to identify complete diabetes remission (FPG < 100 mg/dl, A1c < 6.0%), partial remission (FPG 100–125 mg/dl, A1c < 6.5%), or relapse.

Results

Before surgery, body weight and BMI were 123 ± 21 kg and 44.6 ± 6.8 kg/m² respectively; at a mean follow-up of 7 years (range 4–10), body weight was 104.9 ± 18 kg and BMI 37 ± 6 kg/m². Minimum weight was reached after 2 years. T2DM remission was observed in 66, 57, and 52% at short (< 2 years), medium (2–5 years), and long-term (> 5 years) follow-up respectively. Furthermore, 45.2% maintained complete remission for at least 5 years and about 36% showed a persistent but improved diabetes. None of the patients cured from diabetes had a duration disease greater than 8 years and a glycemic control requiring insulin. The prevalence of hypertension and dyslipidemia significantly decreased from 49 to 35% and from 51 to 40% respectively.

Conclusions

LSG significantly improves body weight, diabetes, hypertension, and dyslipidemia in long-term follow-up.

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Title: Long-term Metabolic Effects of Laparoscopic Sleeve Gastrectomy
Authors: Danila Capoccia
Federica Coccia
Gloria Guarisco
Moira Testa
Roberta Rendina
Francesca Abbatini
Gianfranco Silecchia
Frida Leonetti
Publication date: 01-08-2018
Publisher: Springer US
Published in: Obesity Surgery / Issue 8/2018
Print ISSN: 0960-8923
Electronic ISSN: 1708-0428
DOI: https://doi.org/10.1007/s11695-018-3153-8

At a glance: The STEP trials

Springer Medicine

Long-term Metabolic Effects of Laparoscopic Sleeve Gastrectomy

Abstract

Objective

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Objective

Methods

Results

Conclusions

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