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Obesity Surgery
Published in: Obesity Surgery 3/2011

01-03-2011 | Clinical Research

Changes in Lipid Profiles in Morbidly Obese Patients After Laparoscopic Sleeve Gastrectomy (LSG)

Authors: Feng Zhang, Gladys Witt Strain, Wen Lei, Gregory F. Dakin, Michel Gagner, Alfons Pomp

Published in: Obesity Surgery | Issue 3/2011

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Abstract

Background

Laparoscopic sleeve gastrectomy (LSG) has evolved as a primary weight loss surgery. This study provides changes in lipid profiles in obese patients 1 year after LSG.

Methods

A retrospective analysis of patients who underwent LSG from June 2004 to June 2008 provided data on demographics, body mass index (BMI) changes, co-morbidities, and medication changes. We compared lipid profiles, and the relationship between the lipid profiles and pre-operative weight, BMI, and weight loss. Proportion changes for all variables were also assessed. Lipid profiles for those taking lipid-lowering therapy and patients receiving no medication were evaluated.

Results

Data is presented on 45 patients (58% women) ages 18 to 73 years. Co-morbidities included hypertension (19), hyperlipidemia (22), and diabetes (13). One year after LSG, weight decreased from 161.4 ± 34.3 to 112.9 ± 25.6 kg (p < 0.01). BMI decreased from 57.5 ± 9.6 to 39.9 ± 7.1 kg/m2 (p < 0.01). Patients with elevated triglycerides decreased from 17 to 8 (p < 0.01) while patients with elevated cholesterol increased from 13 to 15. High-density lipoprotein cholesterol (HDL) increased from 48.4 to 54.5 mg/dl (p < 0.01) and triglycerides (TG) decreased from 141.7 to 109.3 mg/dl (p < 0.01). TC/HDL and TG/HDL ratios also, decreased significantly (p < 0.01). There were no changes for total cholesterol (TC) and low-density lipoprotein cholesterol (LDL). TG/HDL changes correlated with pre-op weight (r = 0.363, p < 0.05).

Conclusions

One year after LSG, significant weight loss and improvements in HDL and TG levels, TC/HDL and TG/HDL ratios were observed. TC and LDL levels were unchanged.
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Metadata
Title
Changes in Lipid Profiles in Morbidly Obese Patients After Laparoscopic Sleeve Gastrectomy (LSG)
Authors
Feng Zhang
Gladys Witt Strain
Wen Lei
Gregory F. Dakin
Michel Gagner
Alfons Pomp
Publication date
01-03-2011
Publisher
Springer-Verlag
Published in
Obesity Surgery / Issue 3/2011
Print ISSN: 0960-8923
Electronic ISSN: 1708-0428
DOI
https://doi.org/10.1007/s11695-010-0285-x

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