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01-10-2017 | Original Article

Long Non-Coding RNA SPRY4-IT1 Can Predict Unfavorable Prognosis and Lymph Node Metastasis: a Meta-Analysis

Authors: Nandi Li, Qian Tan, Wei Jing, Ping Luo, Jiancheng Tu

Published in: Pathology & Oncology Research | Issue 4/2017

Abstract

Emerging evidences suggested that long non-coding RNAs (lncRNAs) play an interesting role in the tumor development and progression in various types of cancer. The aim of this study was to analyse the potential prognostic value for cancer patients . We systematically searched the reports through PubMed, Web of Science, Medline, CNKI, and the Cochrane Library from inception to March, 2016, and carefully identified according to eligibility criteria. This quantitative meta-analysis collected all relevant articles to investigated the association of SPRY4-IT1 expression status with overall survival (OS) and lymph node metastasis (LNM). A total of 765 patients with cancer from 8 studies were included in the final analysis. The hazard ratio (HR) of OS and the odds ratios (OR) of LNM were calculated to assess the association . The meta-analysis results showed high SPRY4-IT1 expression could predict unfavorable OS in various cancers (pooled HR: 2.18, 95% CI: 1.45–3.27, p = 0.001). Moreover, we found high SPRY4-IT1 expression was related to LNM (pooled OR = 3.86, 95%CI:1.31–11.35, P = 0.01). LncRNA SPRY4-IT1 can serve as a new molecular marker for cancer metastasis and prognosis.

Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F (2015) Cancer incidence and mortality worldwide: sources, methods and major patterns in globocan 2012. Int J Cancer 136:E359–E386CrossRefPubMed

Siegel RL, Miller KD, Jemal A (2016) Cancer statistics, 2016. CA Cancer J Clin 66:7–30CrossRefPubMed

Knauss JL, Sun T (2013) Regulatory mechanisms of long noncoding rnas in vertebrate central nervous system development and function. Neuroscience 235:200–214CrossRefPubMedPubMedCentral

Tano K, Akimitsu N (2012) Long non-coding rnas in cancer progression. Front Genet 3:219CrossRefPubMedPubMedCentral

Li G, Zhang H, Wan X, Yang X, Zhu C, Wang A, He L, Miao R, Chen S, Zhao H (2014) Long noncoding rna plays a key role in metastasis and prognosis of hepatocellular carcinoma. Biomed Res Int 2014:780521PubMedPubMedCentral

Yao Y, Li J, Wang L (2014) Large intervening non-coding rna hotair is an indicator of poor prognosis and a therapeutic target in human cancers. Int J Mol Sci 15:18985–18999CrossRefPubMedPubMedCentral

Cai B, Wu Z, Liao K, Zhang S (2014) Long noncoding rna hotair can serve as a common molecular marker for lymph node metastasis: a meta-analysis. Tumour Biol 35:8445–8450CrossRefPubMed

Cheetham SW, Gruhl F, Mattick JS, Dinger ME (2013) Long noncoding rnas and the genetics of cancer. Br J Cancer 108:2419–2425CrossRefPubMedPubMedCentral

Khaitan D, Dinger ME, Mazar J, Crawford J, Smith MA, Mattick JS, Perera RJ (2011) The melanoma-upregulated long noncoding rna spry4-it1 modulates apoptosis and invasion. Cancer Res 71:3852–3862CrossRefPubMed

10.

Xie HW, Wu QQ, Zhu B, Chen FJ, Ji L, Li SQ, Wang CM, Tong YS, Tuo L, Wu M, Liu ZH, Lv J, Shi WH, Cao XF (2014) Long noncoding rna spry4-it1 is upregulated in esophageal squamous cell carcinoma and associated with poor prognosis. Tumour Biol 35:7743–7754CrossRefPubMed

11.

Shi Y, Li J, Liu Y, Ding J, Fan Y, Tian Y, Wang L, Lian Y, Wang K, Shu Y (2015) The long noncoding rna spry4-it1 increases the proliferation of human breast cancer cells by upregulating znf703 expression. Mol Cancer 14:51CrossRefPubMedPubMedCentral

12.

Zhang HM, Yang FQ, Yan Y, Che JP, Zheng JH (2014) High expression of long non-coding rna spry4-it1 predicts poor prognosis of clear cell renal cell carcinoma. Int J Clin Exp Pathol 7:5801–5809PubMedPubMedCentral

13.

Liu T, Shen SK, Xiong JG, Xu Y, Zhang HQ, Liu HJ, Lu ZG (2016) Clinical significance of long noncoding rna spry4-it1 in melanoma patients. FEBS Open Bio 6:147–154CrossRefPubMedPubMedCentral

14.

Zhao XL, Zhao ZH, Xu WC, Hou JQ, Du XY (2015) Increased expression of spry4-it1 predicts poor prognosis and promotes tumor growth and metastasis in bladder cancer. Int J Clin Exp Pathol 8:1954–1960PubMedPubMedCentral

15.

Zhou Y, Wang DL, Pang Q (2016) Long noncoding rna spry4-it1 is a prognostic factor for poor overall survival and has an oncogenic role in glioma. Eur Rev Med Pharmacol Sci 20:3035–3039PubMed

16.

Cui F, Wu D, He X, Wang W, Xi J, Wang M (2016) Long noncoding rna spry4-it1 promotes esophageal squamous cell carcinoma cell proliferation, invasion, and epithelial-mesenchymal transition. Tumor Biology, 2016, 37(8):1-6.

17.

Peng W, Wu G, Fan H, Wu J, Feng J (2015) Long noncoding rna spry4-it1 predicts poor patient prognosis and promotes tumorigenesis in gastric cancer. Tumour Biol 36:6751–6758CrossRefPubMed

18.

Chen MW, Li JF, Zhuang CL, Liu YC, Chen ZC, He AB, Zhang QX, Huang WR, Cai ZM (2016) Long noncoding rna spry4-it1 inhibited the progression of bladder cancer. Acta Universitatis Medicinalis Anhui 51:978-983,984.

19.

Tierney JF, Stewart LA, Ghersi D, Burdett S, Sydes MR (2007) Practical methods for incorporating summary time-to-event data into meta-analysis. Trials 8:16CrossRefPubMedPubMedCentral

20.

Xie HW, Chen FJ, Zhu B, Cao G, Jin L, Zhou GZ, Lv Z, Cao XF (2013) Long noncoding rna spry4-it1 expression in esophageal squamous cell carcinoma and its effects on cell growth. Chinese Journal of Clinical Oncology 40(17):1011-1015. doi:10.3969/j.issn.1000-8179.20130707

21.

Qiu MT, Hu JW, Yin R, Xu L (2013) Long noncoding rna: an emerging paradigm of cancer research. Tumour Biol 34:613–620CrossRefPubMed

22.

Guttman M, Rinn JL (2012) Modular regulatory principles of large non-coding rnas. Nature 482:339–346CrossRefPubMedPubMedCentral

23.

Bartonicek N, Maag JL, Dinger ME (2016) Long noncoding rnas in cancer: mechanisms of action and technological advancements. Mol Cancer 15:43CrossRefPubMedPubMedCentral

24.

Brunner AL, Beck AH, Edris B, Sweeney RT, Zhu SX, Li R, Montgomery K, Varma S, Gilks T, Guo X, Foley JW, Witten DM, Giacomini CP, Flynn RA, Pollack JR, Tibshirani R, Chang HY, van de Rijn M, West RB (2012) Transcriptional profiling of long non-coding rnas and novel transcribed regions across a diverse panel of archived human cancers. Genome Biol 13:R75CrossRefPubMedPubMedCentral

25.

Lai MC, Yang Z, Zhou L, Zhu QQ, Xie HY, Zhang F, Wu LM, Chen LM, Zheng SS (2012) Long non-coding rna malat-1 overexpression predicts tumor recurrence of hepatocellular carcinoma after liver transplantation. Med Oncol 29:1810–1816CrossRefPubMed

26.

Li J, Wen W, Zhao S, Wang J, Chen J, Wang Y, Zhang Q (2015) Prognostic role of hotair in four estrogen-dependent malignant tumors: a meta-analysis. Onco Targets Ther 8:1471–1482CrossRefPubMedPubMedCentral

27.

Zhang J, Zhang B, Wang T, Wang H (2015) Lncrna malat1 overexpression is an unfavorable prognostic factor in human cancer: evidence from a meta-analysis. Int J Clin Exp Med 8:5499–5505PubMedPubMedCentral

28.

Zhao W, Mazar J, Lee B, Sawada J, Li JL, Shelley J, Govindarajan S, Towler D, Mattick JS, Komatsu M, Dinger ME, Perera RJ (2016) The long noncoding rna sprightly regulates cell proliferation in primary human melanocytes. J Invest Dermatol 136:819–828CrossRefPubMedPubMedCentral

29.

Mazar J, Zhao W, Khalil AM, Lee B, Shelley J, Govindarajan SS, Yamamoto F, Ratnam M, Aftab MN, Collins S, Finck BN, Han X, Mattick JS, Dinger ME, Perera RJ (2014) The functional characterization of long noncoding rna spry4-it1 in human melanoma cells. Oncotarget 5:8959–8969CrossRefPubMedPubMedCentral

30.

Liu H, Lv Z, Guo E (2015) Knockdown of long noncoding rna spry4-it1 suppresses glioma cell proliferation, metastasis and epithelial-mesenchymal transition. Int J Clin Exp Pathol 8:9140–9146PubMedPubMedCentral

31.

Ru N, Liang J, Zhang F, Wu W, Wang F, Liu X, Du Y (2016) Spry4 intronic transcript 1 promotes epithelial-mesenchymal transition through association with snail1 in osteosarcoma. DNA Cell Biol 35:290–295CrossRefPubMed

32.

Zhang CY, Li RK, Qi Y, Li XN, Yang Y, Liu DL, Zhao J, Zhu DY, Wu K, Zhou XD, Zhao S (2016) Upregulation of long noncoding rna spry4-it1 promotes metastasis of esophageal squamous cell carcinoma via induction of epithelial-mesenchymal transition. Cell Biol Toxicol 32(5):391–401. doi:10.1007/s10565-016-9341-1

Title: Long Non-Coding RNA SPRY4-IT1 Can Predict Unfavorable Prognosis and Lymph Node Metastasis: a Meta-Analysis
Authors: Nandi Li
Qian Tan
Wei Jing
Ping Luo
Jiancheng Tu
Publication date: 01-10-2017
Publisher: Springer Netherlands
Published in: Pathology & Oncology Research / Issue 4/2017
Print ISSN: 1219-4956
Electronic ISSN: 1532-2807
DOI: https://doi.org/10.1007/s12253-016-0182-2

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