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Endocrine

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01-11-2018 | Review

LncRNAs and miRs as epigenetic signatures in diabetic cardiac fibrosis: new advances and perspectives

Authors: Hui Tao, Zheng-Yu Song, Xuan-Sheng Ding, Jing-Jing Yang, Kai-Hu Shi, Jun Li

Published in: Endocrine | Issue 2/2018

Abstract

Purpose

Diabetic cardiomyopathy (DCM) is a serious cardiac complication of diabetes, which further lead to heartfailure. It is known that diabetes-induced cardiac fibrosis is a key pathogenic factor contributing topathological changes in DCM. However, pathogenetic mechanisms underlying diabetes cardiac fibrosis arestill elusive. Recent studies have indicated that noncoding RNAs (ncRNAs) play a key role in diabetescardiac fibrosis. The increasing complexity of epigenetic regulator poses great challenges to ourconventional conceptions regarding how ncRNAs regulate diabetes cardiac fibrosis.

Methods

We searched PubMed, Web of Science, and Scopus for manuscripts published prior to April 2018 using keywords "Diabetic cardiomyopathy" AND " diabetes cardiac fibrosis " OR " noncoding RNAs " OR " longnoncoding RNAs " OR " microRNAs " OR "epigenetic". Manuscripts were collated, studied and carriedforward for discussion where appropriate.

Results

Based on the view that during diabetic cardiac fibrosis, ncRNAs are able to regulate diabetic cardiac fibrosisby targeting genes involved in epigenetic pathways. Many studies have focused on ncRNAs, an epigeneticregulator deregulating protein-coding genes in diabetic cardiac fibrosis, to identify potential therapeutictargets. Recent advances and new perspectives have found that long noncoding RNAs and microRNAs,exert their own effects on the progression of diabetic cardiac fibrosis.

Conclusion

We firstly examine the growing role of ncRNAs characteristics and ncRNAs-regulated genes involved indiabetic cardiac fibrosis. Then, we provide several possible therapeutic strategies and highlight the potentialof molecular mechanisms in which targeting epigenetic regulators are considered as an effective means of treating diabetic cardiac fibrosis.

Y. Shiga, M. Kuriyama, Y. Kanaya, S. Takeshima, M. Takemaru, K. Takamatsu, Y. Shimoe, Y. Fujikawa, M. Nishigaki, Serum 1,5-anhydroglucitol: risk factor of acute ischemic stroke and transient ischemic attack in well-controlled diabetes. Cerebrovasc. Dis. 44(5-6), 325–329 (2017). https://doi.org/10.1159/000481626 CrossRefPubMed

F. Orio, G. Muscogiuri, C. Nese, S. Palomba, S. Savastano, D. Tafuri, G. Colarieti, G. La Sala, A. Colao, B.O. Yildiz, Obesity, type 2 diabetes mellitus and cardiovascular disease risk: an uptodate in the management of polycystic ovary syndrome. Eur. J. Obstet. Gynecol. Reprod. Biol. 207, 214–219 (2016). https://doi.org/10.1016/j.ejogrb.2016.08.026 CrossRefPubMed

M. Afzal, S. Saleem, N. Singh, I. Kazmi, R. Khan, M.S. Nadeem, M.A. Zamzami, F.A. Al-Abbasi, F. Anwar, Evaluation of diphenhydramine in talc induced type 2 diabetes mellitus in Wistar rats. Biomed. Pharmacother. 97, 652–655 (2017). https://doi.org/10.1016/j.biopha.2017.10.085 CrossRefPubMed

M. Awazawa, P. Gabel, E. Tsaousidou, H. Nolte, M. Kruger, J. Schmitz, P.J. Ackermann, C. Brandt, J. Altmuller, S. Motameny, F.T. Wunderlich, J.W. Kornfeld, M. Bluher, J.C. Bruning, A microRNA screen reveals that elevated hepatic ectodysplasin A expression contributes to obesity-induced insulin resistance in skeletal muscle. Nat. Med. (2017). https://doi.org/10.1038/nm.4420 CrossRef

D.V. Skarra, A. Hernandez-Carretero, A.J. Rivera, A.R. Anvar, V.G. Thackray, Hyperandrogenemia induced by letrozole treatment of pubertal female mice results in hyperinsulinemia prior to weight gain and insulin resistance. Endocrinology 158(9), 2988–3003 (2017). https://doi.org/10.1210/en.2016-1898 CrossRefPubMedPubMedCentral

L. Ernande, E. Audureau, C.L. Jellis, C. Bergerot, C. Henegar, D. Sawaki, G. Czibik, C. Volpi, F. Canoui-Poitrine, H. Thibault, J. Ternacle, P. Moulin, T.H. Marwick, G. Derumeaux, Clinical implications of echocardiographic phenotypes of patients with diabetes mellitus. J. Am. Coll. Cardiol. 70(14), 1704–1716 (2017). https://doi.org/10.1016/j.jacc.2017.07.792 CrossRefPubMed

D. Bai, Y. Zhang, M. Shen, Y. Sun, Q. Xia, X. Liu, H. Wang, L. Yuan, Hyperglycemia and hyperlipidemia blunts the Insulin-Inpp5f negative feedback loop in the diabetic heart. Sci. Rep. 6, 22068 (2016). https://doi.org/10.1038/srep22068 CrossRefPubMedPubMedCentral

A. Sharma, B.G. Demissei, J. Tromp, H.L. Hillege, J.G. Cleland, C.M. O’Connor, M. Metra, P. Ponikowski, J.R. Teerlink, B.A. Davison, M.M. Givertz, D.M. Bloomfield, H. Dittrich, D.J. van Veldhuisen, G. Cotter, J.A. Ezekowitz, M.A.F. Khan, A.A. Voors, A network analysis to compare biomarker profiles in patients with and without diabetes mellitus in acute heart failure. Eur. J. Heart Fail. 19(10), 1310–1320 (2017). https://doi.org/10.1002/ejhf.912 CrossRefPubMed

S.F. Mohammed, S. Hussain, S.A. Mirzoyev, W.D. Edwards, J.J. Maleszewski, M.M. Redfield, Coronary microvascular rarefaction and myocardial fibrosis in heart failure with preserved ejection fraction. Circulation 131(6), 550–559 (2015). https://doi.org/10.1161/CIRCULATIONAHA.114.009625 CrossRefPubMed

10.

X. Zhang, L. Pan, K. Yang, Y. Fu, Y. Liu, J. Chi, S. Hong, X. Ma, X. Yin, H3 relaxin protects against myocardial injury in experimental diabetic cardiomyopathy by inhibiting myocardial apoptosis, fibrosis and inflammation. Cell. Physiol. Biochem. 43(4), 1311–1324 (2017). https://doi.org/10.1159/000481843 CrossRefPubMed

11.

Y. Bulani, S.S. Sharma, Argatroban attenuates diabetic cardiomyopathy in rats by reducing fibrosis, inflammation, apoptosis, and protease-activated receptor expression. Cardiovasc Drugs Ther. (2017). https://doi.org/10.1007/s10557-017-6732-3 CrossRef

12.

Y. Ding, X. Sun, P.F. Shan, MicroRNAs and cardiovascular disease in diabetes mellitus. Biomed. Res. Int. 2017, 4080364 (2017). https://doi.org/10.1155/2017/4080364 CrossRefPubMedPubMedCentral

13.

A. Elgheznawy, L. Shi, J. Hu, I. Wittig, H. Laban, J. Pircher, A. Mann, P. Provost, V. Randriamboavonjy, I. Fleming, Dicer cleavage by calpain determines platelet microRNA levels and function in diabetes. Circ. Res. 117(2), 157–165 (2015). https://doi.org/10.1161/CIRCRESAHA.117.305784 CrossRefPubMed

14.

L. Maya, F.J. Villarreal, Diagnostic approaches for diabetic cardiomyopathy and myocardial fibrosis. J. Mol. Cell. Cardiol. 48(3), 524–529 (2010). https://doi.org/10.1016/j.yjmcc.2009.06.021 CrossRefPubMed

15.

M. Schnelle, N. Catibog, M. Zhang, A.A. Nabeebaccus, G. Anderson, D.A. Richards, G. Sawyer, X. Zhang, K. Toischer, G. Hasenfuss, M.J. Monaghan, A.M. Shah, Echocardiographic evaluation of diastolic function in mouse models of heart disease. J. Mol. Cell. Cardiol. 114, 20–28 (2017). https://doi.org/10.1016/j.yjmcc.2017.10.006 CrossRefPubMed

16.

X. Lin, P. Yang, E.A. Reece, Pregestational type 2 diabetes mellitus induces cardiac hypertrophy in the murine embryo through cardiac remodeling and fibrosis. Am. J. Obstet. Gynecol. 217(2), 216 e211–216 e213 (2017). https://doi.org/10.1016/j.ajog.2017.04.008 CrossRef

17.

I. Russo, N.G. Frangogiannis, Diabetes-associated cardiac fibrosis: cellular effectors, molecular mechanisms and therapeutic opportunities. J. Mol. Cell. Cardiol. 90, 84–93 (2016). https://doi.org/10.1016/j.yjmcc.2015.12.011 CrossRefPubMed

18.

B. Liu, A.M. Dardeer, W.E. Moody, N.C. Edwards, L.E. Hudsmith, R.P. Steeds, Normal values for myocardial deformation within the right heart measured by feature-tracking cardiovascular magnetic resonance imaging. Int. J. Cardiol. (2017). https://doi.org/10.1016/j.ijcard.2017.10.106 CrossRef

19.

A. Taye, M.M. Abouzied, O.M. Mohafez, Tempol ameliorates cardiac fibrosis in streptozotocin-induced diabetic rats: role of oxidative stress in diabetic cardiomyopathy. Naunyn-Schmiedeberg’s Arch. Pharmacol. 386(12), 1071–1080 (2013). https://doi.org/10.1007/s00210-013-0904-x CrossRef

20.

A.V. Shinde, N.G. Frangogiannis, Fibroblasts in myocardial infarction: a role in inflammation and repair. J. Mol. Cell. Cardiol. 70, 74–82 (2014). https://doi.org/10.1016/j.yjmcc.2013.11.015 CrossRefPubMed

21.

S.D. Prabhu, N.G. Frangogiannis, The biological basis for cardiac repair after myocardial infarction: from inflammation to fibrosis. Circ. Res. 119(1), 91–112 (2016). https://doi.org/10.1161/CIRCRESAHA.116.303577 CrossRefPubMedPubMedCentral

22.

A.V. Shinde, C. Humeres, N.G. Frangogiannis, The role of alpha-smooth muscle actin in fibroblast-mediated matrix contraction and remodeling. Biochim. Biophys. Acta 1863(1), 298–309 (2017). https://doi.org/10.1016/j.bbadis.2016.11.006 CrossRef

23.

D.Y. Shu, F.J. Lovicu, Myofibroblast transdifferentiation: the dark force in ocular wound healing and fibrosis. Prog. Retin. Eye. Res. 60, 44–65 (2017). https://doi.org/10.1016/j.preteyeres.2017.08.001 CrossRefPubMedPubMedCentral

24.

S. Seok, Y.C. Kim, S. Byun, S. Choi, Z. Xiao, N. Iwamori, Y. Zhang, C. Wang, J. Ma, K. Ge, B. Kemper, J.K. Kemper, Fasting-induced JMJD3 histone demethylase epigenetically activates mitochondrial fatty acid beta-oxidation. The J. Clin. Invest. (2018). https://doi.org/10.1172/JCI97736 CrossRef

25.

X. Corso-Diaz, C. Jaeger, V. Chaitankar, A. Swaroop, Epigenetic control of gene regulation during development and disease: a view from the retina. Prog. Retinal Eye Res. (2018). https://doi.org/10.1016/j.preteyeres.2018.03.002 CrossRef

26.

M. Mitsiogianni, T. Amery, R. Franco, V. Zoumpourlis, A. Pappa, M.I. Panayiotidis, From chemo-prevention to epigenetic regulation: the role of isothiocyanates in skin cancer prevention. Pharmacol. Ther. (2018). https://doi.org/10.1016/j.pharmthera.2018.06.001 CrossRef

27.

T.J. Stevenson, Epigenetic regulation of biological rhythms: an evolutionary ancient molecular timer. Trends Genet. (2017). https://doi.org/10.1016/j.tig.2017.11.003 CrossRef

28.

D. Veneziano, S. Di Bella, G. Nigita, A. Lagana, A. Ferro, C.M. Croce, Noncoding RNA: current deep sequencing data analysis approaches and challenges. Hum. Mutat. 37(12), 1283–1298 (2016). https://doi.org/10.1002/humu.23066 CrossRefPubMed

29.

J. Gao, W. Xu, J. Wang, K. Wang, P. Li, The role and molecular mechanism of non-coding RNAs in pathological cardiac remodeling. Int. J. Mol. Sci. (2017). https://doi.org/10.3390/ijms18030608 CrossRef

30.

E.K. Herter, N. Xu Landen, Non-coding RNAs: new players in skin wound healing. Adv. Wound Care 6(3), 93–107 (2017). https://doi.org/10.1089/wound.2016.0711 CrossRef

31.

Y. Guo, F. Luo, Q. Liu, D. Xu, Regulatory non-coding RNAs in acute myocardial infarction. J. Cell. Mol. Med. 21(5), 1013–1023 (2017). https://doi.org/10.1111/jcmm.13032 CrossRefPubMed

32.

A.S. Bayoumi, K.M. Park, Y. Wang, J.P. Teoh, T. Aonuma, Y. Tang, H. Su, N.L. Weintraub, I.M. Kim, A carvedilol-responsive microRNA, miR-125b-5p protects the heart from acute myocardial infarction by repressing pro-apoptotic bak1 and klf13 in cardiomyocytes. J. Mol. Cell. Cardiol. 114, 72–82 (2017). https://doi.org/10.1016/j.yjmcc.2017.11.003 CrossRefPubMedPubMedCentral

33.

V. Sasidharan, S. Marepally, S.A. Elliott, S. Baid, V. Lakshmanan, N. Nayyar, D. Bansal, A. Sanchez Alvarado, P.K. Vemula, D. Palakodeti, The miR-124 family of microRNAs is crucial for regeneration of the brain and visual system in the planarian Schmidtea mediterranea. Development 144(18), 3211–3223 (2017). https://doi.org/10.1242/dev.144758 CrossRefPubMedPubMedCentral

34.

F. Yu, K.A. Pillman, C.T. Neilsen, J. Toubia, D.M. Lawrence, A. Tsykin, M.P. Gantier, D.F. Callen, G.J. Goodall, C.P. Bracken, Naturally existing isoforms of miR-222 have distinct functions. Nucleic Acids Res. 45(19), 11371–11385 (2017). https://doi.org/10.1093/nar/gkx788 CrossRefPubMedPubMedCentral

35.

S. Ohno, K. Itano, Y. Harada, K. Asada, K. Oikawa, M. Kashiwazako, H. Okuyama, K. Kumagai, M. Takanashi, K. Sudo, N. Ikeda, M. Kuroda, Development of novel small hairpin RNAs that do not require processing by Dicer or AGO2. Mol. Ther. 24(7), 1278–1289 (2016). https://doi.org/10.1038/mt.2016.81 CrossRefPubMedPubMedCentral

36.

J. Hu, T. Sun, H. Wang, Z. Chen, S. Wang, L. Yuan, T. Liu, H.R. Li, P. Wang, Y. Feng, Q. Wang, R.E. McLendon, A.H. Friedman, S.T. Keir, D.D. Bigner, J. Rathmell, X.D. Fu, Q.J. Li, X.F. Wang, MiR-215 is induced post-transcriptionally via HIF-Drosha complex and mediates glioma-initiating cell adaptation to hypoxia by targeting KDM1B. Cancer Cell. 29(1), 49–60 (2016). https://doi.org/10.1016/j.ccell.2015.12.005 CrossRefPubMedPubMedCentral

37.

C. Sardu, M. Barbieri, M.R. Rizzo, P. Paolisso, G. Paolisso, R. Marfella, Cardiac resynchronization therapy outcomes in type 2 diabetic patients: role of microRNA changes. J. Diabetes Res. 2016, 7292564 (2016). https://doi.org/10.1155/2016/7292564 CrossRefPubMed

38.

C. Yang, G. Wang, J. Yang, L. Wang, Long noncoding RNA NBAT1 negatively modulates growth and metastasis of osteosarcoma cells through suppression of miR-21. Am. J. Cancer Res. 7(10), 2009–2019 (2017)PubMedPubMedCentral

39.

J. Zhang, Z. Tao, Y. Wang, Long noncoding RNA DANCR regulates the proliferation and osteogenic differentiation of human bone-derived marrow mesenchymal stem cells via the p38 MAPK pathway. Int. J. Mol. Med. (2017). https://doi.org/10.3892/ijmm.2017.3215

40.

H. Wu, Q.F. Yin, Z. Luo, R.W. Yao, C.C. Zheng, J. Zhang, J.F. Xiang, L. Yang, L.L. Chen, Unusual processing generates SPA LncRNAs that sequester multiple RNA binding proteins. Mol. Cell 64(3), 534–548 (2016). https://doi.org/10.1016/j.molcel.2016.10.007 CrossRefPubMed

41.

D.H. Kim, S. Sung, Vernalization-triggered intragenic chromatin loop formation by long noncoding RNAs. Dev. Cell. 40(3), 302–312 e304 (2017). https://doi.org/10.1016/j.devcel.2016.12.021 CrossRefPubMedPubMedCentral

42.

M.E. Whitely, J.L. Robinson, M.C. Stuebben, H.A. Pearce, M.A.P. McEnery, E. Cosgriff-Hernandez, Prevention of oxygen inhibition of PolyHIPE radical polymerization using a thiol-based crosslinker. ACS Biomater. Sci. Eng. 3(3), 409–419 (2017). https://doi.org/10.1021/acsbiomaterials.6b00663 CrossRefPubMedPubMedCentral

43.

Y. Nedelec, J. Sanz, G. Baharian, Z.A. Szpiech, A. Pacis, A. Dumaine, J.C. Grenier, A. Freiman, A.J. Sams, S. Hebert, A. Page Sabourin, F. Luca, R. Blekhman, R.D. Hernandez, R. Pique-Regi, J. Tung, V. Yotova, L.B. Barreiro, Genetic aancestry and natural selection drive population differences in immune responses to pathogens. Cell 167(3), 657–669 e621 (2016). https://doi.org/10.1016/j.cell.2016.09.025 CrossRefPubMed

44.

A.G. Bert, B.V. Johnson, E.W. Baxter, P.N. Cockerill, A modular enhancer is differentially regulated by GATA and NFAT elements that direct different tissue-specific patterns of nucleosome positioning and inducible chromatin remodeling. Mol. Cell. Biol. 27(8), 2870–2885 (2007). https://doi.org/10.1128/MCB.02323-06 CrossRefPubMedPubMedCentral

45.

E.S.B. Salem, G.C. Fan, Pathological effects of exosomes in mediating diabetic cardiomyopathy. Adv. Exp. Med. Biol. 998, 113–138 (2017). https://doi.org/10.1007/978-981-10-4397-0_8 CrossRefPubMedPubMedCentral

46.

T.R. Mercer, J.S. Mattick, Structure and function of long noncoding RNAs in epigenetic regulation. Nat. Struct. Mol. Biol. 20(3), 300–307 (2013). https://doi.org/10.1038/nsmb.2480 CrossRefPubMed

47.

R.W. Newberry, R.T. Raines, A prevalent intraresidue hydrogen bond stabilizes proteins. Nat. Chem. Biol. 12(12), 1084–1088 (2016). https://doi.org/10.1038/nchembio.2206 CrossRefPubMedPubMedCentral

48.

M.S. Leisegang, C. Fork, I. Josipovic, F.M. Richter, J. Preussner, J. Hu, M.J. Miller, J. Epah, P. Hofmann, S. Gunther, F. Moll, C. Valasarajan, J. Heidler, Y. Ponomareva, T.M. Freiman, L. Maegdefessel, K.H. Plate, M. Mittelbronn, S. Uchida, C. Kunne, K. Stellos, R.T. Schermuly, N. Weissmann, K. Devraj, I. Wittig, R.A. Boon, S. Dimmeler, S.S. Pullamsetti, M. Looso, F.J. Miller Jr., R.P. Brandes, Long noncoding RNA MANTIS facilitates endothelial angiogenic function. Circulation 136(1), 65–79 (2017). https://doi.org/10.1161/CIRCULATIONAHA.116.026991 CrossRefPubMedPubMedCentral

49.

Y. Zhang, Y.Y. Zhang, T.T. Li, J. Wang, Y. Jiang, Y. Zhao, X.X. Jin, G.L. Xue, Y. Yang, X.F. Zhang, Y.Y. Sun, Z.R. Zhang, X. Gao, Z.M. Du, Y.J. Lu, B.F. Yang, Z.W. Pan, Ablation of interleukin-17 alleviated cardiac interstitial fibrosis and improved cardiac function via inhibiting long non-coding RNA-AK081284 in diabetic mice. J. Mol. Cell. Cardiol. 115, 64–72 (2018). https://doi.org/10.1016/j.yjmcc.2018.01.001 CrossRefPubMed

50.

A.A. Thomas, B. Feng, S. Chakrabarti, ANRIL regulates production of extracellular matrix proteins and vasoactive factors in diabetic complications. Am. J. Physiol. Endocrinol. Metab. 314(3), E191–E200 (2018). https://doi.org/10.1152/ajpendo.00268.2017 CrossRefPubMed

51.

X. Zhou, W. Zhang, M. Jin, J. Chen, W. Xu, X. Kong, lncRNA MIAT functions as a competing endogenous RNA to upregulate DAPK2 by sponging miR-22-3p in diabetic cardiomyopathy. Cell Death Dis. 8(7), e2929 (2017). https://doi.org/10.1038/cddis.2017.321 CrossRefPubMedPubMedCentral

52.

Z. Liu, Y. Zhang, Z. Tang, J. Xu, M. Ma, S. Pan, C. Qiu, G. Guan, J. Wang, Matrine attenuates cardiac fibrosis by affecting ATF6 signaling pathway in diabetic cardiomyopathy. Eur. J. Pharmacol. 804, 21–30 (2017). https://doi.org/10.1016/j.ejphar.2017.03.061 CrossRefPubMed

53.

Z.W. Huang, L.H. Tian, B. Yang, R.M. Guo, Long noncoding RNA H19 acts as a competing endogenous RNA to mediate CTGF expression by sponging miR-455 in cardiac fibrosis. DNA Cell Biol. 36(9), 759–766 (2017). https://doi.org/10.1089/dna.2017.3799 CrossRefPubMed

54.

V. Kesherwani, H.R. Shahshahan, P.K. Mishra, Cardiac transcriptome profiling of diabetic Akita mice using microarray and next generation sequencing. PLoS ONE. 12(8), e0182828 (2017). https://doi.org/10.1371/journal.pone.0182828 CrossRefPubMedPubMedCentral

55.

C. Zhuo, R. Jiang, X. Lin, M. Shao, LncRNA H19 inhibits autophagy by epigenetically silencing of DIRAS3 in diabetic cardiomyopathy. Oncotarget 8(1), 1429–1437 (2017). https://doi.org/10.18632/oncotarget.13637 CrossRefPubMed

56.

X. Li, H. Wang, B. Yao, W. Xu, J. Chen, X. Zhou, lncRNA H19/miR-675 axis regulates cardiomyocyte apoptosis by targeting VDAC1 in diabetic cardiomyopathy. Sci. Rep. 6, 36340 (2016). https://doi.org/10.1038/srep36340 CrossRefPubMedPubMedCentral

57.

D. Prakoso, M.J. De Blasio, C. Qin, S. Rosli, H. Kiriazis, H. Qian, X.J. Du, K.L. Weeks, P. Gregorevic, J.R. McMullen, R.H. Ritchie, Phosphoinositide 3-kinase (p110alpha) gene delivery limits diabetes-induced cardiac NADPH oxidase and cardiomyopathy in a mouse model with established diastolic dysfunction. Clin. Sci. (Lond.) 131(12), 1345–1360 (2017). https://doi.org/10.1042/CS20170063 CrossRef

58.

D. de Gonzalo-Calvo, F. Kenneweg, C. Bang, R. Toro, R.W. van der Meer, L.J. Rijzewijk, J.W. Smit, H.J. Lamb, V. Llorente-Cortes, T. Thum, Circulating long-non coding RNAs as biomarkers of left ventricular diastolic function and remodelling in patients with well-controlled type 2 diabetes. Sci. Rep. 6, 37354 (2016). https://doi.org/10.1038/srep37354 CrossRefPubMedPubMedCentral

59.

M. Zhang, H. Gu, J. Chen, X. Zhou, Involvement of long noncoding RNA MALAT1 in the pathogenesis of diabetic cardiomyopathy. Int. J. Cardiol. 202, 753–755 (2016). https://doi.org/10.1016/j.ijcard.2015.10.019 CrossRefPubMed

60.

M. Zhang, H. Gu, W. Xu, X. Zhou, Down-regulation of lncRNA MALAT1 reduces cardiomyocyte apoptosis and improves left ventricular function in diabetic rats. Int. J. Cardiol. 203, 214–216 (2016). https://doi.org/10.1016/j.ijcard.2015.10.136 CrossRefPubMed

61.

A.S. Bayoumi, J.P. Teoh, T. Aonuma, Z. Yuan, X. Ruan, Y. Tang, H. Su, N.L. Weintraub, I.M. Kim, MicroRNA-532 protects the heart in acute myocardial infarction, and repressesprss23, a positive regulator of endothelial-to-mesenchymal transition. Cardiovasc. Res. 113(13), 1603–1614 (2017). https://doi.org/10.1093/cvr/cvx132 CrossRefPubMedPubMedCentral

62.

M. Di Pierro, R.R. Cheng, E. Lieberman Aiden, P.G. Wolynes, J.N. Onuchic, De novo prediction of human chromosome structures: epigenetic marking patterns encode genome architecture. Proc. Natl Acad. Sci. USA 114 (46), 12126-12131 (2017). https://doi.org/10.1073/pnas.1714980114 CrossRef

63.

R.M. Spengler, X. Zhang, C. Cheng, J.M. McLendon, J.M. Skeie, F.L. Johnson, B.L. Davidson, R.L. Boudreau, Elucidation of transcriptome-wide microRNA binding sites in human cardiac tissues by Ago2 HITS-CLIP. Nucleic Acids Res. 44(15), 7120–7131 (2016). https://doi.org/10.1093/nar/gkw640 CrossRefPubMedPubMedCentral

64.

K. McJunkin, Maternal effects of microRNAs in early embryogenesis. RNA Biol. (2017). https://doi.org/10.1080/15476286.2017.1402999 CrossRef

65.

Y. Yue, K. Meng, Y. Pu, X. Zhang, Transforming growth factor beta (TGF-beta) mediates cardiac fibrosis and induces diabetic cardiomyopathy. Diabetes Res. Clin. Pract. 133, 124–130 (2017). https://doi.org/10.1016/j.diabres.2017.08.018 CrossRefPubMed

66.

M. Zarkesh, A. Zadeh-Vakili, F. Azizi, F. Foroughi, M.M. Akhavan, M. Hedayati, Altered epigenetic mechanisms in thyroid cancer subtypes. Mol. Diagn. Ther. (2017). https://doi.org/10.1007/s40291-017-0303-y CrossRef

67.

C.M. Artlett, S. Sassi-Gaha, J.L. Hope, C.A. Feghali-Bostwick, P.D. Katsikis, Mir-155 is overexpressed in systemic sclerosis fibroblasts and is required for NLRP3 inflammasome-mediated collagen synthesis during fibrosis. Arthritis Res. Ther. 19(1), 144 (2017). https://doi.org/10.1186/s13075-017-1331-z CrossRefPubMedPubMedCentral

68.

C. Jia, H. Chen, M. Wei, X. Chen, Y. Zhang, L. Cao, P. Yuan, F. Wang, G. Yang, J. Ma, Gold nanoparticle-based miR155 antagonist macrophage delivery restores the cardiac function in ovariectomized diabetic mouse model. Int. J. Nanomed. 12, 4963–4979 (2017). https://doi.org/10.2147/IJN.S138400 CrossRef

69.

D. Zhang, Y. Cui, B. Li, X. Luo, Y. Tang, miR-155 regulates high glucose-induced cardiac fibrosis via the TGF-beta signaling pathway. Mol. Biosyst. 13(1), 215–224 (2016). https://doi.org/10.1039/c6mb00649c CrossRefPubMed

70.

R. Kishore, S.K. Verma, A.R. Mackie, E.E. Vaughan, T.V. Abramova, I. Aiko, P. Krishnamurthy, Bone marrow progenitor cell therapy-mediated paracrine regulation of cardiac miRNA-155 modulates fibrotic response in diabetic hearts. PLoS ONE. 8(4), e60161 (2013). https://doi.org/10.1371/journal.pone.0060161 CrossRefPubMedPubMedCentral

71.

Y. Guo, X. Zhuang, Z. Huang, J. Zou, D. Yang, X. Hu, Z. Du, L. Wang, X. Liao, Klotho protects the heart from hyperglycemia-induced injury by inactivating ROS and NF-kappaB-mediated inflammation both in vitro and in vivo. Biochim. Biophys. Acta 1864(1), 238–251 (2017). https://doi.org/10.1016/j.bbadis.2017.09.029 CrossRef

72.

X. Liu, H. Mujahid, B. Rong, Q.H. Lu, W. Zhang, P. Li, N. Li, E.S. Liang, Q. Wang, D.Q. Tang, N.L. Li, X.P. Ji, Y.G. Chen, Y.X. Zhao, M.X. Zhang, Irisin inhibits high glucose-induced endothelial-to-mesenchymal transition and exerts a dose-dependent bidirectional effect on diabetic cardiomyopathy. J. Cell. Mol. Med. (2017). https://doi.org/10.1111/jcmm.13360

73.

H. Geng, J. Guan, MiR-18a-5p inhibits endothelial-mesenchymal transition and cardiac fibrosis through the Notch2 pathway. Biochem. Biophys. Res. Commun. 491(2), 329–336 (2017). https://doi.org/10.1016/j.bbrc.2017.07.101 CrossRefPubMed

74.

B. Zhou, J.W. Yu, A novel identified circular RNA, circRNA_010567, promotes myocardial fibrosis via suppressing miR-141 by targeting TGF-beta1. Biochem. Biophys. Res. Commun. 487(4), 769–775 (2017). https://doi.org/10.1016/j.bbrc.2017.04.044 CrossRefPubMed

75.

S. Rawal, P.E. Munasinghe, P.T. Nagesh, J.K.S. Lew, G.T. Jones, M.J.A. Williams, P. Davis, D. Bunton, I.F. Galvin, P. Manning, R.R. Lamberts, R. Katare, Down-regulation of miR-15a/b accelerates fibrotic remodelling in the Type 2 diabetic human and mouse heart. Clin. Sci. (Lond.) 131(9), 847–863 (2017). https://doi.org/10.1042/CS20160916 CrossRef

76.

B. Feng, S. Chen, A.D. Gordon, S. Chakrabarti, miR-146a mediates inflammatory changes and fibrosis in the heart in diabetes. J. Mol. Cell. Cardiol. 105, 70–76 (2017). https://doi.org/10.1016/j.yjmcc.2017.03.002 CrossRefPubMed

77.

P. Habibi, A. Alihemmati, M. Nasirzadeh, H. Yousefi, M. Habibi, N. Ahmadiasl, Involvement of microRNA-133 and -29 in cardiac disturbances in diabetic ovariectomized rats. Iran. J. Basic Med. Sci. 19(11), 1177–1185 (2016)PubMedPubMedCentral

78.

S.I. Ohkura, S. Usui, S.I. Takashima, N. Takuwa, K. Yoshioka, Y. Okamoto, Y. Inagaki, N. Sugimoto, T. Kitano, M. Takamura, T. Wada, S. Kaneko, Y. Takuwa, Augmented sphingosine 1 phosphate receptor-1 signaling in cardiac fibroblasts induces cardiac hypertrophy and fibrosis through angiotensin II and interleukin-6. PLoS ONE. 12(8), e0182329 (2017). https://doi.org/10.1371/journal.pone.0182329 CrossRefPubMedPubMedCentral

79.

Y. Zhang, J.H. Wang, Y.Y. Zhang, Y.Z. Wang, J. Wang, Y. Zhao, X.X. Jin, G.L. Xue, P.H. Li, Y.L. Sun, Q.H. Huang, X.T. Song, Z.R. Zhang, X. Gao, B.F. Yang, Z.M. Du, Z.W. Pan, Deletion of interleukin-6 alleviated interstitial fibrosis in streptozotocin-induced diabetic cardiomyopathy of mice through affecting TGF beta1 and miR-29 pathways. Sci. Rep. 6, 23010 (2016). https://doi.org/10.1038/srep23010 CrossRefPubMedPubMedCentral

80.

S.K. Raut, A. Kumar, G.B. Singh, U. Nahar, V. Sharma, A. Mittal, R. Sharma, M. Khullar, miR-30c mediates upregulation of Cdc42 and Pak1 in diabetic cardiomyopathy. Cardiovasc. Ther. 33(3), 89–97 (2015). https://doi.org/10.1111/1755-5922.12113 CrossRefPubMed

81.

S. Liu, W. Li, M. Xu, H. Huang, J. Wang, X. Chen, Micro-RNA 21 targets dual specific phosphatase 8 to promote collagen synthesis in high glucose-treated primary cardiac fibroblasts. Can. J. Cardiol. 30(12), 1689–1699 (2014). https://doi.org/10.1016/j.cjca.2014.07.747 CrossRefPubMed

82.

N.M. Sharma, S.S. Nandi, H. Zheng, P.K. Mishra, K.P. Patel, A novel role for miR-133a in centrally mediated activation of the renin-angiotensin system in congestive heart failure. Am. J. Physiol. Heart Circ. Physiol. 312(5), H968–H979 (2017). https://doi.org/10.1152/ajpheart.00721.2016 CrossRefPubMedPubMedCentral

83.

S. Chen, P. Puthanveetil, B. Feng, S.J. Matkovich, G.W. Dorn 2nd, S. Chakrabarti, Cardiac miR-133a overexpression prevents early cardiac fibrosis in diabetes. J. Cell. Mol. Med. 18(3), 415–421 (2014). https://doi.org/10.1111/jcmm.12218 CrossRefPubMedPubMedCentral

84.

X. Liu, E. Liang, X. Song, Z. Du, Y. Zhang, Y. Zhao, Inhibition of Pin1 alleviates myocardial fibrosis and dysfunction in STZ-induced diabetic mice. Biochem. Biophys. Res. Commun. 479(1), 109–115 (2016). https://doi.org/10.1016/j.bbrc.2016.09.050 CrossRefPubMed

Title: LncRNAs and miRs as epigenetic signatures in diabetic cardiac fibrosis: new advances and perspectives
Authors: Hui Tao
Zheng-Yu Song
Xuan-Sheng Ding
Jing-Jing Yang
Kai-Hu Shi
Jun Li
Publication date: 01-11-2018
Publisher: Springer US
Published in: Endocrine / Issue 2/2018
Print ISSN: 1355-008X
Electronic ISSN: 1559-0100
DOI: https://doi.org/10.1007/s12020-018-1688-z

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