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Medical Molecular Morphology
Published in: Medical Molecular Morphology 1/2020

01-03-2020 | Liver Transplantation | Case Report

Idiopathic copper toxicosis: is abnormal copper metabolism a primary cause of this disease?

Authors: Masaru Harada, Yuichi Honma, Tomoharu Yoshizumi, Keiichiro Kumamoto, Shinji Oe, Noboru Harada, Aya Tanimoto, Kei Yabuki, Tsukasa Karasuyama, Akitoshi Yoneda, Michihiko Shibata

Published in: Medical Molecular Morphology | Issue 1/2020

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Abstract

Idiopathic copper toxicosis (ICT) is characterized by marked copper deposition, Mallory-Denk body (MDB) formation and severe hepatic injury. Although the characteristics are apparently different from Wilson disease, large amounts of copper accumulate in the liver of the patients. We extensively treated a patient with ICT to reduce the body copper, however, the patient needed liver transplantation. Previous liver biopsy revealed high copper content. But extirpated liver contained an extremely small amount of copper, although MDBs and severe inflammation remained. These phenomena suggest abnormal copper metabolism is not the principle cause of ICT but some other abnormality must exist.
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Metadata
Title
Idiopathic copper toxicosis: is abnormal copper metabolism a primary cause of this disease?
Authors
Masaru Harada
Yuichi Honma
Tomoharu Yoshizumi
Keiichiro Kumamoto
Shinji Oe
Noboru Harada
Aya Tanimoto
Kei Yabuki
Tsukasa Karasuyama
Akitoshi Yoneda
Michihiko Shibata
Publication date
01-03-2020

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