Published in:
01-06-2019 | Liver Transplantation | Original Article
Postoperative decrease in plasma acyl ghrelin levels after pediatric living donor liver transplantation in association with hepatic damage due to ischemia and reperfusion injury
Authors:
Masahiro Zenitani, Hiroshi Hosoda, Tasuku Kodama, Ryuta Saka, Yuichi Takama, Takehisa Ueno, Yuko Tazuke, Kenji Kangawa, Takaharu Oue, Hiroomi Okuyama
Published in:
Pediatric Surgery International
|
Issue 6/2019
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Abstract
Purpose
Ghrelin was recently reported to promote recovery from hepatic injury. We hypothesized that it could also be associated with clinical recovery of the transplanted liver from ischemia and reperfusion injury. Our aims were to investigate perioperative ghrelin changes following pediatric living donor liver transplantation (LDLT) and to analyze the association of these changes with postoperative hepatic function.
Methods
We measured plasma acyl ghrelin (AG) concentrations before surgery, at the end of surgery and on postoperative days (PODs) 1, 3 and 7 in 12 children who underwent LDLTs, and, as controls, pre- and post-operatively and on POD1 in 7 children who underwent benign abdominal mass resection. The correlations between the participants’ ghrelin profiles and hepatic function-related data were evaluated.
Results
AG levels significantly declined to 15.6% of preoperative levels after LDLT and almost returned to baseline on POD3. Post-operative AG levels were significantly reduced to a greater extent following LDLT than benign abdominal mass resection. AG levels on POD1 inversely correlated with aspartate aminotransferase levels and cold/total ischemia time (P < 0.05).
Conclusion
These results suggest that reduced AG levels on POD1 may reflect the degree of damage to the transplanted liver due to ischemia and reperfusion injury.