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01-02-2021 | Liver Transplantation | Original Article

Model for end-stage liver disease score predicts complications after liver transplantation

Authors: Hans-Christian Pommergaard, Thomas Røjkjær Daugaard, Andreas Arendtsen Rostved, Nicolai Aagaard Schultz, Jens Hillingsø, Paul Suno Krohn, Allan Rasmussen

Published in: Langenbeck's Archives of Surgery | Issue 1/2021

Abstract

Purpose

Increased model for end-stage liver disease (MELD) score measured in the early postoperative course is associated with one-year mortality and graft loss. However, the correlation with postoperative complications has not been investigated. The aim of this study was to investigate the association between postoperative MELD score and subsequent complications.

Methods

Adult liver transplant recipients transplanted from January 2011 until December 2016 were included. MELD score days 1–5 were correlated with complications day 6–30, subdivided into type and severity according to Clavien-Dindo classification.

Results

We included 246 adult liver transplant recipients. Between days 6 and 30, 671 complications occurred in 201 of the patients (82%) corresponding to 64% of all postoperative complications in the whole postoperative period (days 0–30). In multivariate analyses adjusted for recipient gender and age, preoperative MELD score, and Eurotransplant Donor Risk Index, postoperative MELD score was significantly associated with having one or more complications, any type of complication except cardiovascular and renal complications, and complication severity.

Conclusions

Postoperative MELD score days 1–5 were associated with complications arising in the subsequent period 6–30 days after transplantation. An increased MELD score should heighten the clinician’s awareness of a possible complication.

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Title: Model for end-stage liver disease score predicts complications after liver transplantation
Authors: Hans-Christian Pommergaard
Thomas Røjkjær Daugaard
Andreas Arendtsen Rostved
Nicolai Aagaard Schultz
Jens Hillingsø
Paul Suno Krohn
Allan Rasmussen
Publication date: 01-02-2021
Publisher: Springer Berlin Heidelberg
Keywords: Liver Transplantation
Liver Transplantation
Liver Transplantation
Liver Transplantation
Liver Transplantation
Published in: Langenbeck's Archives of Surgery / Issue 1/2021
Print ISSN: 1435-2443
Electronic ISSN: 1435-2451
DOI: https://doi.org/10.1007/s00423-020-02018-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Model for end-stage liver disease score predicts complications after liver transplantation

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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