Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
Journal of Translational Medicine
Published in: Journal of Translational Medicine 1/2016

Open Access 01-12-2016 | Research

Liposome encapsulated perfluorohexane enhances radiotherapy in mice without additional oxygen supply

Authors: Linfeng Xu, Xuefeng Qiu, Yanting Zhang, Kai Cao, Xiaozhi Zhao, Jinhui Wu, Yiqiao Hu, Hongqian Guo

Published in: Journal of Translational Medicine | Issue 1/2016

Login to get access

Abstract

Background

To investigate the effect of perfluorochemical preparations in enhancing radiotherapy, perfluocarbon nanoparticles were by encapsulating perfluorohexane into liposome [lip(PFH)].

Methods

After intravenous injection, lip(PFH) could accumulate in the tumor site over time, with a prominent accumulation in tumor 24 h post injection. X-ray was delivered to the tumor site 24 h after the injection of lip(PFH) under room air. The experimental mice were randomized into four groups: control (saline), lip(PFH) (lip(PFH) only), X-ray (X-ray only), and lip(PFH) + X-ray (lip(PFH) with X-ray radiation). Tumor volume and histology were monitored to assess treatment efficacy.

Results

Tumor growth was significantly reduced in mice received lip(PFH) and X-ray compared with X-ray only. The histological data also revealed more destruction of tumor tissue in lip(PFH) + X-ray group compared with X-ray only. In addition, lip(PFH) did not show any significant tissue damage to major organs or induce significant liver/kidney dysfunction.

Conclusions

Lip(PFH) could accumulate in the tumor site and enhance radiotherapy without additional oxygen supply.
Literature
1.
Brown JM, Wilson WR. Exploiting tumour hypoxia in cancer treatment. Nat Rev Cancer. 2004;4(6):437–47.CrossRefPubMed
2.
Overgaard J, Horsman MR. Modification of hypoxia-induced radioresistance in tumors by the use of oxygen and sensitizers. Semin Radiat Oncol. 1996;6(1):10–21.CrossRefPubMed
3.
Vaupel P, Mayer A. Hypoxia in cancer: significance and impact on clinical outcome. Cancer Metastasis Rev. 2007;26(2):225–39.CrossRefPubMed
4.
Fyles AW, Milosevic M, Wong R, Kavanagh MC, Pintilie M, Sun A, Chapman W, Levin W, Manchul L, Keane TJ, et al. Oxygenation predicts radiation response and survival in patients with cervix cancer. Radiother Oncol. 1998;48(2):149–56.CrossRefPubMed
5.
Aebersold DM, Burri P, Beer KT, Laissue J, Djonov V, Greiner RH, Semenza GL. Expression of hypoxia-inducible factor-1alpha: a novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer. Cancer Res. 2001;61(7):2911–6.PubMed
6.
7.
Linberg R, Conover CD, Shum KL, Shorr RG. Increased tissue oxygenation and enhanced radiation sensitivity of solid tumors in rodents following polyethylene glycol conjugated bovine hemoglobin administration. Vivo. 1998;12(2):167–73.
8.
Murayama C, Kawaguchi AT, Ishikawa K, Kamijo A, Kato N, Ohizumi Y, Sadahiro S, Haida M. Liposome-encapsulated hemoglobin ameliorates tumor hypoxia and enhances radiation therapy to suppress tumor growth in mice. Artif Organs. 2012;36(2):170–7.CrossRefPubMed
9.
Teicher BA, Rose CM. Oxygen-carrying perfluorochemical emulsion as an adjuvant to radiation therapy in mice. Cancer Res. 1984;44(10):4285–8.PubMed
10.
Teicher BA, Herman TS, Jones SM. Optimization of perfluorochemical levels with radiation therapy in mice. Cancer Res. 1989;49(10):2693–7.PubMed
11.
Koch CJ, Oprysko PR, Shuman AL, Jenkins WT, Brandt G, Evans SM. Radiosensitization of hypoxic tumor cells by dodecafluoropentane: a gas-phase perfluorochemical emulsion. Cancer Res. 2002;62(13):3626–9.PubMed
12.
Thomas C, Lartigau E, Malaise EP, Guichard M. New high O2 carrying perfluorochemical emulsions and/or carbogen: reactions of a human tumor xenograft to irradiation. Int J Radiat Oncol Biol Phys. 1989;16(5):1157–60.CrossRefPubMed
13.
Rockwell S, Kelley M, Irvin CG, Hughes CS, Yabuki H, Porter E, Fischer JJ. Preclinical evaluation of oxygent as an adjunct to radiotherapy. Biomater Artif Cells Immobiliz Biotechnol. 1992;20(2–4):883–93.
14.
Song CW, Lee I, Hasegawa T, Rhee JG, Levitt SH. Increase in pO2 and radiosensitivity of tumors by Fluosol-DA (20%) and carbogen. Cancer Res. 1987;47(2):442–6.PubMed
15.
Cheng Y, Cheng H, Jiang C, Qiu X, Wang K, Huan W, Yuan A, Wu J, Hu Y. Perfluorocarbon nanoparticles enhance reactive oxygen levels and tumour growth inhibition in photodynamic therapy. Nat Commun. 2015;6:8785.CrossRefPubMedPubMedCentral
16.
Yuan A, Qiu X, Tang X, Liu W, Wu J, Hu Y. Self-assembled PEG-IR-780-C13 micelle as a targeting, safe and highly-effective photothermal agent for in vivo imaging and cancer therapy. Biomaterials. 2015;51:184–93.CrossRefPubMed
17.
Yu M, Dai M, Liu Q, Xiu R. Oxygen carriers and cancer chemo- and radiotherapy sensitization: bench to bedside and back. Cancer Treat Rev. 2007;33(8):757–61.CrossRefPubMed
18.
Rockwell S, Irvin CG, Kelley M. Preclinical studies of a perfluorochemical emulsion as an adjunct to radiotherapy. Int J Radiat Oncol Biol Phys. 1988;15(4):913–20.CrossRefPubMed
19.
Moulder JE, Fish BL. Intermittent use of a perfluorochemical emulsion (Fluosol-DA 20%) and carbogen breathing with fractionated irradiation. Int J Radiat Oncol Biol Phys. 1988;15(5):1193–6.CrossRefPubMed
20.
Teicher BA, Rose CM. Perfluorochemical emulsions can increase tumor radiosensitivity. Science. 1984;223(4639):934–6.CrossRefPubMed
21.
Rockwell S, Mate TP, Irvin CG, Nierenburg M. Reactions of tumors and normal tissues in mice to irradiation in the presence and absence of a perfluorochemical emulsion. Int J Radiat Oncol Biol Phys. 1986;12(8):1315–8.CrossRefPubMed
22.
Rockwell S. Use of a perfluorochemical emulsion to improve oxygenation in a solid tumor. Int J Radiat Oncol Biol Phys. 1985;11(1):97–103.CrossRefPubMed
23.
Rose C, Lustig R, McIntosh N, Teicher B. A clinical trial of Fluosol DA 20% in advanced squamous cell carcinoma of the head and neck. Int J Radiat Oncol Biol Phys. 1986;12(8):1325–7.CrossRefPubMed
24.
Waldow SM, Lustig RA, Brass-Marlow EL, Nunno MP, Holst RJ, Wallner PE. Effect of Fluosol-DA 20% and oxygen on response of C57BL/6 mice to whole-body irradiation. Int J Radiat Oncol Biol Phys. 1990;19(3):665–8.CrossRefPubMed
25.
Johnson JL, Leos RA, Baker AF, Unger EC. Radiosensitization of Hs-766T pancreatic tumor xenografts in mice dosed with dodecafluoropentane nano-emulsion-preliminary findings. J Biomed Nanotechnol. 2015;11(2):274–81.CrossRefPubMed
26.
Jain RK. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science. 2005;307(5706):58–62.CrossRefPubMed
27.
Vaupel P, Schlenger K, Knoop C, Hockel M. Oxygenation of human tumors: evaluation of tissue oxygen distribution in breast cancers by computerized O2 tension measurements. Cancer Res. 1991;51(12):3316–22.PubMed
28.
Brown JM, Giaccia AJ. The unique physiology of solid tumors: opportunities (and problems) for cancer therapy. Cancer Res. 1998;58(7):1408–16.PubMed
29.
Davis ME, Chen ZG, Shin DM. Nanoparticle therapeutics: an emerging treatment modality for cancer. Nat Rev Drug Discov. 2008;7(9):771–82.CrossRefPubMed
30.
Peer D, Karp JM, Hong S, Farokhzad OC, Margalit R, Langer R. Nanocarriers as an emerging platform for cancer therapy. Nat Nanotechnol. 2007;2(12):751–60.CrossRefPubMed
31.
Geyer RP. Oxygen transport in vivo by means of perfluorochemical preparations. N Engl J Med. 1982;307(5):304–5.CrossRefPubMed
Metadata
Title
Liposome encapsulated perfluorohexane enhances radiotherapy in mice without additional oxygen supply
Authors
Linfeng Xu
Xuefeng Qiu
Yanting Zhang
Kai Cao
Xiaozhi Zhao
Jinhui Wu
Yiqiao Hu
Hongqian Guo
Publication date
01-12-2016
Publisher
BioMed Central
Published in
Journal of Translational Medicine / Issue 1/2016
Electronic ISSN: 1479-5876
DOI
https://doi.org/10.1186/s12967-016-1033-3

Other articles of this Issue 1/2016

Journal of Translational Medicine 1/2016 Go to the issue

Review

mTOR inhibitors effects on regulatory T cells and on dendritic cells

Review

Retroviral vectors and transposons for stable gene therapy: advances, current challenges and perspectives

Research

Walking performance is positively correlated to calf muscle fiber size in peripheral artery disease subjects, but fibers show aberrant mitophagy: an observational study

Research

An ex vivo human cartilage repair model to evaluate the potency of a cartilage cell transplant

Research

Inhibition of cancer cell growth by ruthenium complexes

Research

LncRNA MALAT1 promotes development of mantle cell lymphoma by associating with EZH2
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Reserve your place

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

Read more

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Pediatric Cardiology Video

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

Cardiopulmonary Comorbidity Video

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Valvular Heart Disease Video

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

Watch now

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

16-04-2024 Type 2 Diabetes News

Incentivised to exercise

11-04-2024 Lifestyle Modifications News

New intervention for STEMI-related cardiogenic shock

10-04-2024 Myocardial Infarction News

» View more highlights on the ACC 2024 congress hub page

Image Credits