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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 3/2020

01-12-2020 | Liposarcoma | ASO Author Reflections

ASO Author Reflections: Moving the Needle in Extremity and Trunk Soft Tissue Sarcoma

Authors: Christina L. Roland, MD, MS, Winan van Houdt, MD, Alessandro Gronchi, MD

Published in: Annals of Surgical Oncology | Special Issue 3/2020

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Excerpt

Data from seminal randomized trials over the last several decades has resulted in local control rates of 80–95% of patients with localized extremity and trunk sarcoma (ETSTS) undergoing limb-sparing surgery with pre- or postoperative radiation therapy (RT) and anthracycline-based chemotherapy;1 however, up to 50% of patients with localized disease will develop distant metastases. Although doxorubicin (± ifosfamide) has remained the backbone of systemic chemotherapy for ETSTS over the last 40 years, it benefits only a subset of patients with sometimes significant toxicity, highlighting the need for novel therapies in this rare disease. …
Literature
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Koseła-Paterczyk H, Szumera-Ciećkiewicz A, Szacht M, et al. Efficacy of neoadjuvant hypofractionated radiotherapy in patients with locally advanced myxoid liposarcoma. Eur J Surg Oncol. 2016;42(6):891–8.CrossRef
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Callegaro D, Miceli R, Bonvalot S, et al. Development and external validation of two nomograms to predict overall survival and occurrence of distant metastases in adults after surgical resection of localised soft-tissue sarcomas of the extremities: a retrospective analysis. Lancet Oncol. 2016;17(5):671–80.CrossRef
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Ratan R, Patel SR. Chemotherapy for soft tissue sarcoma. Cancer. 2016;122(19):2952–60.CrossRef
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Metadata
Title
ASO Author Reflections: Moving the Needle in Extremity and Trunk Soft Tissue Sarcoma
Authors
Christina L. Roland, MD, MS
Winan van Houdt, MD
Alessandro Gronchi, MD
Publication date
01-12-2020
Publisher
Springer International Publishing
Published in
Annals of Surgical Oncology / Issue Special Issue 3/2020
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-020-09028-x

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