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Current Obesity Reports

12-04-2024 | Lipolysis | REVIEW

The Different Shades of Thermogenic Adipose Tissue

Authors: Yunwen Hu, Yijie Huang, Yangjing Jiang, Lvkan Weng, Zhaohua Cai, Ben He

Published in: Current Obesity Reports

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Abstract

Purpose of Review

By providing a concise overview of adipose tissue types, elucidating the regulation of adipose thermogenic capacity in both physiological contexts and chronic wasting diseases (a protracted hypermetabolic state that precipitates sustained catabolism and consequent progressive corporeal atrophy), and most importantly, delving into the ongoing discourse regarding the role of adipose tissue thermogenic activation in chronic wasting diseases, this review aims to provide researchers with a comprehensive understanding of the field.

Recent Findings

Adipose tissue, traditionally classified as white, brown, and beige (brite) based on its thermogenic activity and potential, is intricately regulated by complex mechanisms in response to exercise or cold exposure. This regulation is adipose depot-specific and dependent on the duration of exposure. Excessive thermogenic activation of adipose tissue has been observed in chronic wasting diseases and has been considered a pathological factor that accelerates disease progression. However, this conclusion may be confounded by the detrimental effects of excessive lipolysis. Recent research also suggests that such activation may play a beneficial role in the early stages of chronic wasting disease and provide potential therapeutic effects.

Summary

A more comprehensive understanding of the changes in adipose tissue thermogenesis under physiological and pathological conditions, as well as the underlying regulatory mechanisms, is essential for the development of novel interventions to improve health and prevent disease.
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Metadata
Title
The Different Shades of Thermogenic Adipose Tissue
Authors
Yunwen Hu
Yijie Huang
Yangjing Jiang
Lvkan Weng
Zhaohua Cai
Ben He
Publication date
12-04-2024
Publisher
Springer US
Published in
Current Obesity Reports
Electronic ISSN: 2162-4968
DOI
https://doi.org/10.1007/s13679-024-00559-y
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