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Drug Safety
Published in: Drug Safety 10/2011

01-10-2011 | Review Article

Drug-Induced Photosensitivity

Culprit Drugs, Management and Prevention

Authors: Aaron M. Drucker, Dr Cheryl F. Rosen

Published in: Drug Safety | Issue 10/2011

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Abstract

Photo-induced drug eruptions are cutaneous adverse events due to exposure to a drug and either ultraviolet or visible radiation. Based on their pathogenesis, they can be classified as phototoxic or photoallergic drug eruptions, although in many cases it is not possible to determine whether a particular eruption is due to a phototoxic or photoallergic mechanism.
In this review, the diagnosis, prevention and management of drug-induced photosensitivity are discussed. Diagnosis is based primarily on the history of drug intake and the clinical appearance of the eruption, primarily affecting sun-exposed areas of the skin. Phototesting and photopatch testing can be useful adjuncts in making a diagnosis. The mainstay of management is prevention, including informing patients of the possibility of increased sun sensitivity and the use of sun protective measures. However, once the eruption has occurred, it may be necessary to discontinue the culprit medication and treat the eruption with a potent topical corticosteroid. Drugs that have been implicated in causing photosensitive eruptions are reviewed. Tetracycline, doxycycline, nalidixic acid, voriconazole, amiodarone, hydrochlorothiazide, naproxen, piroxicam, chlorpromazine and thioridazine are among the most commonly implicated medications. We review the medical literature regarding evidence for the culpability of each drug, including the results of phototesting, photopatch testing and rechallenge testing.
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Metadata
Title
Drug-Induced Photosensitivity
Culprit Drugs, Management and Prevention
Authors
Aaron M. Drucker
Dr Cheryl F. Rosen
Publication date
01-10-2011
Publisher
Springer International Publishing
Published in
Drug Safety / Issue 10/2011
Print ISSN: 0114-5916
Electronic ISSN: 1179-1942
DOI
https://doi.org/10.2165/11592780-000000000-00000

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