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American Journal of Clinical Dermatology
Published in: American Journal of Clinical Dermatology 2/2000

01-03-2000 | Adis New Drug Profile

Topical Aminolevulinic Acid HCl

A Viewpoint by Edward Jeffes III

Author: Edward Jeffes III

Published in: American Journal of Clinical Dermatology | Issue 2/2000

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Excerpt

Aminolevulinic acid (ALA) is a new class of photosensitizer that can be used in photodynamic therapy (PDT). ALA is a prodrug that is metabolized by the proliferating target cell into protoporphyrin IX (PpIX). PpIX is photoactivated by light (from 405nm to 635nm) to kill the target cell. This approach has been employed to treat a variety of skin neoplasms (squamous cell carcinomas and basal cell carcinomas), and actinic keratosis. …
Literature
1.
Ormrod D.,. Jarvis B. Topical aminolevulinic acid Hcl photodynamic therapy, Am J Clin Dermatol 2000 Mar–Apr; 1(2): 133–139PubMedCrossRef
2.
Product information: Levulan R Kerastick TM (aminolevulinic acid Hcl) for topical solution, 20%. Dusa Pharmaceuticals, Inc.; 1999
3.
Kurwa H.A., Yong-Gee S.A., Seed P.T., et al. A randomized paired comparison of photodynamic therapy and topical 5-fluorouracil in the treatment of actinic keratosis. J Am Acad Dermatol 1999; 41: 414–418.PubMedCrossRef
Metadata
Title
Topical Aminolevulinic Acid HCl
A Viewpoint by Edward Jeffes III
Author
Edward Jeffes III
Publication date
01-03-2000
Publisher
Springer International Publishing
Published in
American Journal of Clinical Dermatology / Issue 2/2000
Print ISSN: 1175-0561
Electronic ISSN: 1179-1888
DOI
https://doi.org/10.2165/00128071-200001020-00010

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