Published in:
01-11-2005 | Adis Drug Profile
Rotigotine
A Viewpoint by Tomislav Babic
Author:
Tomislav Babic
Published in:
CNS Drugs
|
Issue 11/2005
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Excerpt
Dopamine agonists are gaining acceptance not only for the treatment of advanced Parkinson’s disease but also for the initial treatment of early-stage disease. This represents a change from earlier concepts on the management of Parkinson’s disease, which were mainly based on the use of levodopa coupled with dopa-decarboxylase inhibitors. However, the daily ‘peak’ and ‘trough’ blood concentrations of the multiple-dose oral dopamine agonists result in pulsatile stimulation of dopamine receptors, which may contribute to the pathogenesis of motor complications. …