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Published in: Sports Medicine 12/2003

01-10-2003 | Review Article

Popular Sports Supplements and Ergogenic Aids

Author: Mark S. Juhn

Published in: Sports Medicine | Issue 12/2003

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Abstract

This article reviews the evidence-based ergogenic potential and adverse effects of 14 of the most common products in use by recreational and elite athletes today. Both legal and prohibited products are discussed. This is an aggressively marketed and controversial area of sports medicine worldwide. It is therefore prudent for the clinician to be well versed in the more popular supplements and drugs reputed to be ergogenic in order to distinguish fact from fiction.
Antioxidants, proteins and amino acids are essential components of diet, but additional oral supplementation does not increase endurance or strength. Caffeine is ergogenic in certain aerobic activities. Creatine is ergogenic in repetitive anaerobic cycling sprints but not running or swimming. Ephedrine and pseudoephedrine may be ergogenic but have detrimental cardiovascular effects. Erythropoietin is ergogenic but increases the risk of thromboembolic events. β-Hydroxy-β-methylbutyrate has ergogenic potential in untrained individuals, but studies are needed on trained individuals. Human growth hormone and insulin growth factor-I decrease body fat and may increase lean muscle mass when given subcutaneously. Pyruvate is not ergogenic. The androgenic precursors androstenedione and dehydroepiandrosterone have not been shown to increase any parameters of strength and have potentially significant adverse effects. Anabolic steroids increase protein synthesis and muscle mass but with many adverse effects, some irreversible. Supplement claims on labels of product content and efficacy can be inaccurate and misleading.
Footnotes
1
The use of tradenames is for product identification purposes only and does not imply endorsement.
 
Literature
2.
go back to reference Sheppard HL, Raichada SM, Kouri KM, et al. Use of creatine and other supplements by members of civilian and military health clubs: a cross-sectional survey. Int J Sport Nutr Exerc Metab 2000; 10(3): 245–59PubMed Sheppard HL, Raichada SM, Kouri KM, et al. Use of creatine and other supplements by members of civilian and military health clubs: a cross-sectional survey. Int J Sport Nutr Exerc Metab 2000; 10(3): 245–59PubMed
3.
go back to reference Juhn MS, O’Kane JW, Vinci DM. Oral creatine supplementation in male collegiate athletes: a survey of dosing habits and side effects. J Am Diet Assoc 1999; 99(5): 593–5PubMedCrossRef Juhn MS, O’Kane JW, Vinci DM. Oral creatine supplementation in male collegiate athletes: a survey of dosing habits and side effects. J Am Diet Assoc 1999; 99(5): 593–5PubMedCrossRef
5.
go back to reference Clarkson PM, Thompson HS. Antioxidants: what role do they play in physical activity and health? Am J Clin Nutr 2000; 72 (2 Suppl.): 637S–46SPubMed Clarkson PM, Thompson HS. Antioxidants: what role do they play in physical activity and health? Am J Clin Nutr 2000; 72 (2 Suppl.): 637S–46SPubMed
7.
go back to reference American College of Sports Medicine, American Dietetic Association, and Dietitians of Canada. Joint position statement: nutrition and athletic performance. Med Sci Sports Exerc 2000; 32(12): 2130–45CrossRef American College of Sports Medicine, American Dietetic Association, and Dietitians of Canada. Joint position statement: nutrition and athletic performance. Med Sci Sports Exerc 2000; 32(12): 2130–45CrossRef
8.
go back to reference Nielsen AN, Mizuno M, Ratkevicius A, et al. No effect of antioxidant supplementation in triathletes on maximal oxygen uptake, 31P-NMRS detected muscle energy metabolism and muscle fatigue. Int J Sports Med 1999; 20(3): 154–8PubMed Nielsen AN, Mizuno M, Ratkevicius A, et al. No effect of antioxidant supplementation in triathletes on maximal oxygen uptake, 31P-NMRS detected muscle energy metabolism and muscle fatigue. Int J Sports Med 1999; 20(3): 154–8PubMed
9.
go back to reference Buchman AL, Killip D, Ou CN, et al. Short-term vitamin E supplementation before marathon running: a placebo-controlled trial. Nutrition 1999; 15(4): 278–83PubMedCrossRef Buchman AL, Killip D, Ou CN, et al. Short-term vitamin E supplementation before marathon running: a placebo-controlled trial. Nutrition 1999; 15(4): 278–83PubMedCrossRef
10.
go back to reference Weston SB, Zhou S, Weatherby RP, et al. Does exogenous coenzyme Q10 affect aerobic capacity in endurance athletes? Int J Sport Nutr 1997; 7(3): 197–206PubMed Weston SB, Zhou S, Weatherby RP, et al. Does exogenous coenzyme Q10 affect aerobic capacity in endurance athletes? Int J Sport Nutr 1997; 7(3): 197–206PubMed
11.
go back to reference Thompson D, Williams C, Kingsley M, et al. Muscle soreness and damage parameters after prolonged intermittent shuttle-running following acute vitamin C supplementation. Int J Sports Med 2001; 22(1): 68–75PubMedCrossRef Thompson D, Williams C, Kingsley M, et al. Muscle soreness and damage parameters after prolonged intermittent shuttle-running following acute vitamin C supplementation. Int J Sports Med 2001; 22(1): 68–75PubMedCrossRef
12.
go back to reference Schroder H, Navarro E, Tramullas A, et al. Nutrition antioxidant status and oxidative stress in professional basketball players: effects of a three compound antioxidative supplement. Int J Sports Med 2000; 21(2): 146–50PubMedCrossRef Schroder H, Navarro E, Tramullas A, et al. Nutrition antioxidant status and oxidative stress in professional basketball players: effects of a three compound antioxidative supplement. Int J Sports Med 2000; 21(2): 146–50PubMedCrossRef
13.
go back to reference Santos-Silva A, Rebelo MI, Castro EM, et al. Leukocyte activation, erythrocyte damage, lipid profile and oxidative stress imposed by high competition physical exercise in adolescents. Clin Chim Acta 2001; 306(1–2): 119–26PubMedCrossRef Santos-Silva A, Rebelo MI, Castro EM, et al. Leukocyte activation, erythrocyte damage, lipid profile and oxidative stress imposed by high competition physical exercise in adolescents. Clin Chim Acta 2001; 306(1–2): 119–26PubMedCrossRef
14.
go back to reference Fredholm BB, Battig K, Holmen J, et al. Actions of caffeine in the brain with special reference to factors that contribute to its widespread use. Pharmacol Rev 1999 Mar; 51(1): 83–133PubMed Fredholm BB, Battig K, Holmen J, et al. Actions of caffeine in the brain with special reference to factors that contribute to its widespread use. Pharmacol Rev 1999 Mar; 51(1): 83–133PubMed
15.
go back to reference Lindskog M, Svenningsson P, Pozzi L, et al. Involvement of DARPP-32 phosphorylation in the stimulant action of caffeine. Nature 2002 Aug 15; 418(6899): 774–8PubMedCrossRef Lindskog M, Svenningsson P, Pozzi L, et al. Involvement of DARPP-32 phosphorylation in the stimulant action of caffeine. Nature 2002 Aug 15; 418(6899): 774–8PubMedCrossRef
16.
go back to reference Graham TE. Caffeine and exercise: metabolism, endurance and performance. Sports Med 2001; 31(11): 785–807PubMedCrossRef Graham TE. Caffeine and exercise: metabolism, endurance and performance. Sports Med 2001; 31(11): 785–807PubMedCrossRef
17.
go back to reference MacIntosh BR, Wright BM. Caffeine ingestion and performance of a 1500-metre swim. Can J Appl Physiol 1995; 20(2): 168–77PubMedCrossRef MacIntosh BR, Wright BM. Caffeine ingestion and performance of a 1500-metre swim. Can J Appl Physiol 1995; 20(2): 168–77PubMedCrossRef
18.
go back to reference Kovacs EM, Stegen JHCH, Brouns F. Effect of caffeinated drinks on substrate metabolism, caffeine excretion, and performance. J Appl Physiol 1998; 85(2): 709–15PubMed Kovacs EM, Stegen JHCH, Brouns F. Effect of caffeinated drinks on substrate metabolism, caffeine excretion, and performance. J Appl Physiol 1998; 85(2): 709–15PubMed
19.
go back to reference Greer F, Friars D, Graham TE. Comparison of caffeine and theophylline ingestion: exercise metabolism and endurance. J Appl Physiol 2000; 89(5): 1837–44PubMed Greer F, Friars D, Graham TE. Comparison of caffeine and theophylline ingestion: exercise metabolism and endurance. J Appl Physiol 2000; 89(5): 1837–44PubMed
20.
go back to reference Pasman WJ, van Baak MA, Jeukendrup AE, et al. The effect of different dosages of caffeine on endurance performance time. Int J Sports Med 1995; 16(4): 225–30PubMedCrossRef Pasman WJ, van Baak MA, Jeukendrup AE, et al. The effect of different dosages of caffeine on endurance performance time. Int J Sports Med 1995; 16(4): 225–30PubMedCrossRef
21.
go back to reference Bruce CR, Anderson ME, Fraser SF, et al. Enhancement of 2000m rowing performance after caffeine ingestion. Med Sci Sports Exerc 2000; 32(11): 1958–63PubMedCrossRef Bruce CR, Anderson ME, Fraser SF, et al. Enhancement of 2000m rowing performance after caffeine ingestion. Med Sci Sports Exerc 2000; 32(11): 1958–63PubMedCrossRef
22.
go back to reference Greer F, McLean C, Graham T. Caffeine, performance, and metabolism during repeated Wingate exercise tests. J Appl Physiol 1998; 85: 1502–8PubMed Greer F, McLean C, Graham T. Caffeine, performance, and metabolism during repeated Wingate exercise tests. J Appl Physiol 1998; 85: 1502–8PubMed
23.
go back to reference Collomp K, Ahmaidi S, Chatard JC, et al. Benefits of caffeine ingestion on sprint performance in trained and untrained swimmers. Eur J Appl Physiol Occup Physiol 1992; 64(4): 377–80PubMedCrossRef Collomp K, Ahmaidi S, Chatard JC, et al. Benefits of caffeine ingestion on sprint performance in trained and untrained swimmers. Eur J Appl Physiol Occup Physiol 1992; 64(4): 377–80PubMedCrossRef
24.
go back to reference Paton CD, Hopkins WG, Vollebregt L. Little effect of caffeine ingestion on repeated sprints in team-sport athletes. Med Sci Sports Exerc 2001; 33(5): 822–5PubMed Paton CD, Hopkins WG, Vollebregt L. Little effect of caffeine ingestion on repeated sprints in team-sport athletes. Med Sci Sports Exerc 2001; 33(5): 822–5PubMed
25.
go back to reference Wemple RD, Lamb DR, McKeever KH. Caffeine vs caffeine-free sports drinks: effects on urine production at rest and during prolonged exercise. Int J Sports Med 1997; 18(1): 40–6PubMedCrossRef Wemple RD, Lamb DR, McKeever KH. Caffeine vs caffeine-free sports drinks: effects on urine production at rest and during prolonged exercise. Int J Sports Med 1997; 18(1): 40–6PubMedCrossRef
27.
go back to reference Mesa JL, Ruiz JR, Gonzalez-Gross MM, et al. Oral creatine supplementation and skeletal muscle metabolism in physical exercise. Sports Med 2002; 32(14): 903–44PubMedCrossRef Mesa JL, Ruiz JR, Gonzalez-Gross MM, et al. Oral creatine supplementation and skeletal muscle metabolism in physical exercise. Sports Med 2002; 32(14): 903–44PubMedCrossRef
28.
go back to reference Juhn MS, Tarnopolsky M. Oral creatine supplementation and athletic performance: a critical review. Clin J Sport Med 1998; 8(4): 286–97PubMedCrossRef Juhn MS, Tarnopolsky M. Oral creatine supplementation and athletic performance: a critical review. Clin J Sport Med 1998; 8(4): 286–97PubMedCrossRef
29.
go back to reference Terjung RL, Clarkson P, Eichner ER, et al. American College of Sports Medicine roundtable: the physiological and health effects of oral creatine supplementation. Med Sci Sports Exerc 2000; 32(3): 706–17PubMedCrossRef Terjung RL, Clarkson P, Eichner ER, et al. American College of Sports Medicine roundtable: the physiological and health effects of oral creatine supplementation. Med Sci Sports Exerc 2000; 32(3): 706–17PubMedCrossRef
30.
go back to reference Hultman E, Soderlund K, Timmons JA, et al. Muscle creatine loading in men. J Appl Physiol 1996; 81(1): 232–7PubMed Hultman E, Soderlund K, Timmons JA, et al. Muscle creatine loading in men. J Appl Physiol 1996; 81(1): 232–7PubMed
31.
go back to reference Haussinger D, Roth E, Lang F, et al. Cellular hydration state: an important determinant of protein catabolism in health and disease. Lancet 1993; 341: 1330–2PubMedCrossRef Haussinger D, Roth E, Lang F, et al. Cellular hydration state: an important determinant of protein catabolism in health and disease. Lancet 1993; 341: 1330–2PubMedCrossRef
32.
go back to reference Parise G, Mihic S, MacLennan D, et al. Effects of acute creatine monohydrate supplementation on leucine kinetics and mixed-muscle protein synthesis. J Appl Physiol 2001; 91(3): 1041–7PubMed Parise G, Mihic S, MacLennan D, et al. Effects of acute creatine monohydrate supplementation on leucine kinetics and mixed-muscle protein synthesis. J Appl Physiol 2001; 91(3): 1041–7PubMed
33.
go back to reference Louis M, Poortmans JR, Francaux M, et al. Creatine supplementation does not further stimulate human myofibrillar or sarcoplasmic protein synthesis after resistance exercise. Am J Physiol Endocrinol Metab. Epub 2003 Jun 24 Louis M, Poortmans JR, Francaux M, et al. Creatine supplementation does not further stimulate human myofibrillar or sarcoplasmic protein synthesis after resistance exercise. Am J Physiol Endocrinol Metab. Epub 2003 Jun 24
34.
go back to reference Smith J, Dahm DL. Creatine use among a select population of high school athletes. Mayo Clin Proc 2000; 75(12): 1257–63PubMedCrossRef Smith J, Dahm DL. Creatine use among a select population of high school athletes. Mayo Clin Proc 2000; 75(12): 1257–63PubMedCrossRef
35.
go back to reference LaBotz M, Smith BW. Creatine supplement use in an NCAA division I athletic program. Clin J Sport Med 1999; 9(3): 167–9PubMedCrossRef LaBotz M, Smith BW. Creatine supplement use in an NCAA division I athletic program. Clin J Sport Med 1999; 9(3): 167–9PubMedCrossRef
36.
go back to reference Green AL, Hultman E, Macdonald IA, et al. Carbohydrate ingestion augments skeletal muscle creatine accumulation during creatine supplementation in humans. Am J Physiol 1996 Nov; 271 (5 Pt 1): E821–6PubMed Green AL, Hultman E, Macdonald IA, et al. Carbohydrate ingestion augments skeletal muscle creatine accumulation during creatine supplementation in humans. Am J Physiol 1996 Nov; 271 (5 Pt 1): E821–6PubMed
37.
go back to reference Benzi G, Ceci A. Creatine as nutritional supplementation and medicinal product. J Sports Med Phys Fitness 2001; 41(1): 1–10PubMed Benzi G, Ceci A. Creatine as nutritional supplementation and medicinal product. J Sports Med Phys Fitness 2001; 41(1): 1–10PubMed
38.
go back to reference Graham AS, Hatton RC. Creatine: a review of efficacy and safety. J Am Pharm Assoc 1999; 39(6): 803–10 Graham AS, Hatton RC. Creatine: a review of efficacy and safety. J Am Pharm Assoc 1999; 39(6): 803–10
39.
go back to reference Tarnopolsky MA, MacLennan DP. Creatine monohydrate supplementation enhances high-intensity exercise performance in males and females. Int J Sport Nutr Exerc Metab 2000; 10(4): 452–63PubMed Tarnopolsky MA, MacLennan DP. Creatine monohydrate supplementation enhances high-intensity exercise performance in males and females. Int J Sport Nutr Exerc Metab 2000; 10(4): 452–63PubMed
40.
go back to reference Bemben MG, Tuttle TD, Bemben DA, et al. Effects of creatine supplementation on isometric force-time curve characteristics. Med Sci Sports Exerc 2001; 33(11): 1876–81PubMedCrossRef Bemben MG, Tuttle TD, Bemben DA, et al. Effects of creatine supplementation on isometric force-time curve characteristics. Med Sci Sports Exerc 2001; 33(11): 1876–81PubMedCrossRef
41.
go back to reference Op’t Eijnde BO, Vergauwen L, Hespel P. Creatine loading does not impact on stroke performance in tennis. Int J Sports Med 2001; 22: 76–80CrossRef Op’t Eijnde BO, Vergauwen L, Hespel P. Creatine loading does not impact on stroke performance in tennis. Int J Sports Med 2001; 22: 76–80CrossRef
42.
go back to reference Hamilton KL, Meyers MC, Skelly WA, et al. Oral creatine supplementation and upper extremity anaerobic response in females. Int J Sports Nutr 2000; 10: 277–89 Hamilton KL, Meyers MC, Skelly WA, et al. Oral creatine supplementation and upper extremity anaerobic response in females. Int J Sports Nutr 2000; 10: 277–89
43.
go back to reference Balsom PD, Harridge SD, Soderlund K, et al. Creatine supplementation per se does not enhance endurance exercise performance. Acta Physiol Scand 1993; 149(4): 521–3PubMedCrossRef Balsom PD, Harridge SD, Soderlund K, et al. Creatine supplementation per se does not enhance endurance exercise performance. Acta Physiol Scand 1993; 149(4): 521–3PubMedCrossRef
44.
go back to reference Mujika I, Padilla S, Ibanez J, et al. Creatine supplementation and sprint performance in soccer players. Med Sci Sports Exerc 2000; 32(2): 518–25PubMedCrossRef Mujika I, Padilla S, Ibanez J, et al. Creatine supplementation and sprint performance in soccer players. Med Sci Sports Exerc 2000; 32(2): 518–25PubMedCrossRef
45.
go back to reference Cox G, Mujika I, Tumilty D, et al. Acute creatine supplementation and performance during a field test simulating match play in elite female soccer players. Int J Sport Nutr Exerc Metab 2002 Mar; 12(1): 33–46PubMed Cox G, Mujika I, Tumilty D, et al. Acute creatine supplementation and performance during a field test simulating match play in elite female soccer players. Int J Sport Nutr Exerc Metab 2002 Mar; 12(1): 33–46PubMed
46.
go back to reference Mujika I, Chatard JC, Lacoste L, et al. Creatine supplementation does not improve sprint performance in competitive swimmers. Med Sci Sports Exerc 1996; 28: 11: 1435–41PubMedCrossRef Mujika I, Chatard JC, Lacoste L, et al. Creatine supplementation does not improve sprint performance in competitive swimmers. Med Sci Sports Exerc 1996; 28: 11: 1435–41PubMedCrossRef
47.
go back to reference Juhn MS, Tarnopolsky M. Potential side effects of oral creatine supplementation: a critical review. Clin J Sport Med 1998; 8(4): 298–304PubMedCrossRef Juhn MS, Tarnopolsky M. Potential side effects of oral creatine supplementation: a critical review. Clin J Sport Med 1998; 8(4): 298–304PubMedCrossRef
48.
go back to reference Schroeder C, Potteiger J, Randall J, et al. The effects of creatine dietary supplementation on anterior compartment pressure in the lower leg during rest and following exercise. Clin J Sport Med 2001; 11(2): 87–95PubMedCrossRef Schroeder C, Potteiger J, Randall J, et al. The effects of creatine dietary supplementation on anterior compartment pressure in the lower leg during rest and following exercise. Clin J Sport Med 2001; 11(2): 87–95PubMedCrossRef
49.
go back to reference McGuine TA, Sullivan JC, Bernardt DT. Creatine supplementation in high school football players. Clin J Sport Med 2001; 11(4): 247–53PubMedCrossRef McGuine TA, Sullivan JC, Bernardt DT. Creatine supplementation in high school football players. Clin J Sport Med 2001; 11(4): 247–53PubMedCrossRef
50.
go back to reference Robinson SJ. Acute quadriceps compartment syndrome and rhabdomyolysis in a weight lifter using high-dose creatine supplementation. J Am Board Fam Pract 2000; 13(2): 134–7PubMed Robinson SJ. Acute quadriceps compartment syndrome and rhabdomyolysis in a weight lifter using high-dose creatine supplementation. J Am Board Fam Pract 2000; 13(2): 134–7PubMed
51.
go back to reference Edmunds JW, Jayapalan S, DiMarco NM, et al. Creatine supplementation increases renal disease progression in Han: SPRD-cy rats. Am J Kidney Dis 2001; 37(1): 73–8PubMedCrossRef Edmunds JW, Jayapalan S, DiMarco NM, et al. Creatine supplementation increases renal disease progression in Han: SPRD-cy rats. Am J Kidney Dis 2001; 37(1): 73–8PubMedCrossRef
52.
go back to reference Koshy KM, Griswold E, Schneeberger EE. Interstitial nephritis in a patient taking creatine. N Engl J Med 1999; 340(10): 814–5PubMedCrossRef Koshy KM, Griswold E, Schneeberger EE. Interstitial nephritis in a patient taking creatine. N Engl J Med 1999; 340(10): 814–5PubMedCrossRef
53.
go back to reference Pritchard NR, Kalra PA. Renal dysfunction accompanying oral creatine supplements. Lancet 1998; 351(9111): 1252–3PubMedCrossRef Pritchard NR, Kalra PA. Renal dysfunction accompanying oral creatine supplements. Lancet 1998; 351(9111): 1252–3PubMedCrossRef
54.
go back to reference Dechent P, Pouwels PJ, Wilken B, et al. Increase of total creatine in human brain after oral supplementation of creatine-monohydrate. Am J Physiol 1999; 277 (3 Pt 2): R698–704PubMed Dechent P, Pouwels PJ, Wilken B, et al. Increase of total creatine in human brain after oral supplementation of creatine-monohydrate. Am J Physiol 1999; 277 (3 Pt 2): R698–704PubMed
55.
go back to reference Ipsiroglu OS, Stromberger C, Ilas J, et al. Changes of tissue creatine concentrations upon oral supplementation of creatine-monohydrate in various animal species. Life Sci 2001; 69(15): 1805–15PubMedCrossRef Ipsiroglu OS, Stromberger C, Ilas J, et al. Changes of tissue creatine concentrations upon oral supplementation of creatine-monohydrate in various animal species. Life Sci 2001; 69(15): 1805–15PubMedCrossRef
56.
go back to reference Bell DG, McLellan TM, Sabiston CM. Effect of ingesting caffeine and ephedrine on 10-km run performance. Med Sci Sports Exerc 2002 Feb; 34(2): 344–9PubMedCrossRef Bell DG, McLellan TM, Sabiston CM. Effect of ingesting caffeine and ephedrine on 10-km run performance. Med Sci Sports Exerc 2002 Feb; 34(2): 344–9PubMedCrossRef
57.
go back to reference Hoffman BB, Lefkowitz RJ. Catecholamines and sympathomimetic drugs: In: Gillman AG, Rall TW, Nies AS, et al., editors. Goodman and Gillman’s the pharmacological basis of therapeutics. New York: Pergamon Press, 1990: 187–220 Hoffman BB, Lefkowitz RJ. Catecholamines and sympathomimetic drugs: In: Gillman AG, Rall TW, Nies AS, et al., editors. Goodman and Gillman’s the pharmacological basis of therapeutics. New York: Pergamon Press, 1990: 187–220
58.
go back to reference Bell DG, Jacobs I, Ellerington K. Effect of caffeine and ephedrine ingestion on anaerobic exercise performance. Med Sci Sports Exerc 2001 Aug; 33(8): 1399–403PubMedCrossRef Bell DG, Jacobs I, Ellerington K. Effect of caffeine and ephedrine ingestion on anaerobic exercise performance. Med Sci Sports Exerc 2001 Aug; 33(8): 1399–403PubMedCrossRef
59.
go back to reference Gillies H, Derman WE, Noakes TD, et al. Pseudoephedrine is without ergogenic effects during prolonged exercise. J Appl Physiol 1996 Dec; 81(6): 2611–7PubMed Gillies H, Derman WE, Noakes TD, et al. Pseudoephedrine is without ergogenic effects during prolonged exercise. J Appl Physiol 1996 Dec; 81(6): 2611–7PubMed
60.
go back to reference Chu KS, Doherty TJ, Parise G, et al. A moderate dose of pseudoephedrine does not alter muscle contraction strength or anaerobic power. Clin J Sport Med 2002 Nov; 12(6): 387–90PubMedCrossRef Chu KS, Doherty TJ, Parise G, et al. A moderate dose of pseudoephedrine does not alter muscle contraction strength or anaerobic power. Clin J Sport Med 2002 Nov; 12(6): 387–90PubMedCrossRef
61.
go back to reference Gill ND, Shield A, Blazevich AJ, et al. Muscular and cardiorespiratory effects of pseudoephedrine in human athletes. Br J Clin Pharmacol 2000 Sep; 50(3): 205–13PubMedCrossRef Gill ND, Shield A, Blazevich AJ, et al. Muscular and cardiorespiratory effects of pseudoephedrine in human athletes. Br J Clin Pharmacol 2000 Sep; 50(3): 205–13PubMedCrossRef
62.
go back to reference Swain RA, Harsha DM, Baenziger J, et al. Do pseudoephedrine or phenylpropanolamine improve maximum oxygen uptake and time to exhaustion? Clin J Sport Med 1997; 7(3): 168–73PubMedCrossRef Swain RA, Harsha DM, Baenziger J, et al. Do pseudoephedrine or phenylpropanolamine improve maximum oxygen uptake and time to exhaustion? Clin J Sport Med 1997; 7(3): 168–73PubMedCrossRef
63.
go back to reference Chester N, Reilly T, Mottram DR. Physiological, subjective and performance effects of pseudoephedrine and phenylpropanolamine during endurance running exercise. Int J Sports Med 2003; 24(1): 3–8PubMedCrossRef Chester N, Reilly T, Mottram DR. Physiological, subjective and performance effects of pseudoephedrine and phenylpropanolamine during endurance running exercise. Int J Sports Med 2003; 24(1): 3–8PubMedCrossRef
64.
go back to reference Thomson PR, editor. Physicians desk reference for nonprescription drugs and dietary supplements. 24th ed. Montvale (NJ): Thomson Healthcare, 2003: 521–730 Thomson PR, editor. Physicians desk reference for nonprescription drugs and dietary supplements. 24th ed. Montvale (NJ): Thomson Healthcare, 2003: 521–730
65.
go back to reference Meadows M. Public health officials caution against ephedra use. Health officials caution consumers against using dietary supplements containing ephedra. The stimulant can have dangerous effects on the nervous system and heart. FDA Consum 2003; 37(3): 8–9PubMed Meadows M. Public health officials caution against ephedra use. Health officials caution consumers against using dietary supplements containing ephedra. The stimulant can have dangerous effects on the nervous system and heart. FDA Consum 2003; 37(3): 8–9PubMed
66.
go back to reference Bent S, Tiedt TN, Odden MC, et al. The relative safety of ephedra compared with other herbal products. Ann Intern Med 2003; 138(6): 468–71PubMed Bent S, Tiedt TN, Odden MC, et al. The relative safety of ephedra compared with other herbal products. Ann Intern Med 2003; 138(6): 468–71PubMed
67.
go back to reference Morgenstern LB, Viscoli CM, Kernan WN, et al. Use of ephedra-containing products and risk for hemorrhagic stroke. Neurology 2003; 60(1): 132–5PubMedCrossRef Morgenstern LB, Viscoli CM, Kernan WN, et al. Use of ephedra-containing products and risk for hemorrhagic stroke. Neurology 2003; 60(1): 132–5PubMedCrossRef
68.
go back to reference Haller CA, Benowitz NL. Adverse cardiovascular and central nervous system events associated with dietary supplements containing ephedra alkaloids. N Engl J Med 2000 Dec 21; 343(25): 1833–8PubMedCrossRef Haller CA, Benowitz NL. Adverse cardiovascular and central nervous system events associated with dietary supplements containing ephedra alkaloids. N Engl J Med 2000 Dec 21; 343(25): 1833–8PubMedCrossRef
69.
go back to reference Choi D, Kim M, Park J. Erythropoietin: physico- and biochemical analysis. J Chromatogr B Biomed Appl 1996; 687(1): 189–99PubMedCrossRef Choi D, Kim M, Park J. Erythropoietin: physico- and biochemical analysis. J Chromatogr B Biomed Appl 1996; 687(1): 189–99PubMedCrossRef
70.
go back to reference Celsing F, Svedenhag J, Pihlstedt P, et al. Effects of anaemia and stepwise-induced polycythaemia on maximal aerobic power in individuals with high and low haemoglobin concentrations. Acta Physiol Scand 1987; 129(1): 47–54PubMedCrossRef Celsing F, Svedenhag J, Pihlstedt P, et al. Effects of anaemia and stepwise-induced polycythaemia on maximal aerobic power in individuals with high and low haemoglobin concentrations. Acta Physiol Scand 1987; 129(1): 47–54PubMedCrossRef
72.
go back to reference Audran M, Gareau R, Matecki S, et al. Effects of erythropoietin administration in training athletes and possible indirect detection in doping control. Med Sci Sports Exerc 1999; 31(5): 639–45PubMedCrossRef Audran M, Gareau R, Matecki S, et al. Effects of erythropoietin administration in training athletes and possible indirect detection in doping control. Med Sci Sports Exerc 1999; 31(5): 639–45PubMedCrossRef
73.
go back to reference Ekblom BT. Blood boosting and sport. Baillieres Best Pract Res Clin Endocrinol Metab 2000; 14(1): 89–98PubMedCrossRef Ekblom BT. Blood boosting and sport. Baillieres Best Pract Res Clin Endocrinol Metab 2000; 14(1): 89–98PubMedCrossRef
74.
go back to reference Ekblom B, Berglund B. Effect of erythropoietin administration on maximal aerobic power. Scand J Med Sci Sports 1991; 1: 88–93CrossRef Ekblom B, Berglund B. Effect of erythropoietin administration on maximal aerobic power. Scand J Med Sci Sports 1991; 1: 88–93CrossRef
75.
go back to reference Singbart G. Adverse effects of erythropoietin in long-term and in acute/short-term treatment. Clin Invest 1994; 72: S36–43 Singbart G. Adverse effects of erythropoietin in long-term and in acute/short-term treatment. Clin Invest 1994; 72: S36–43
76.
go back to reference Sunder-Plassmann G, Horl WH. Effect of erythropoietin on cardiovascular diseases. Am J Kidney Dis 2001; 38 (4 Suppl. 1): S20–5PubMedCrossRef Sunder-Plassmann G, Horl WH. Effect of erythropoietin on cardiovascular diseases. Am J Kidney Dis 2001; 38 (4 Suppl. 1): S20–5PubMedCrossRef
77.
go back to reference Parisotto R, Gore CJ, Emslie KR, et al. A novel method utilising markers of altered erythropoiesis for the detection of recombinant human erythropoietin abuse in athletes. Haematologica 2000; 85(6): 564–72PubMed Parisotto R, Gore CJ, Emslie KR, et al. A novel method utilising markers of altered erythropoiesis for the detection of recombinant human erythropoietin abuse in athletes. Haematologica 2000; 85(6): 564–72PubMed
78.
go back to reference Harrison MH. Effects on thermal stress and exercise on blood volume in humans. Physiol Rev1985; 65(1): 149–209PubMed Harrison MH. Effects on thermal stress and exercise on blood volume in humans. Physiol Rev1985; 65(1): 149–209PubMed
79.
go back to reference Vasquez R, Villena M. Normal hematological values for healthy persons living at 4000 meters in Bolivia. High Alt Med Biol 2001; 2(3): 361–7PubMedCrossRef Vasquez R, Villena M. Normal hematological values for healthy persons living at 4000 meters in Bolivia. High Alt Med Biol 2001; 2(3): 361–7PubMedCrossRef
80.
go back to reference Parisotto R, Wu M, Ashenden MJ, et al. Detection of recombinant human erythropoietin abuse in athletes utilizing markers of altered erythropoiesis. Haematologica 2001; 86(2): 128–37PubMed Parisotto R, Wu M, Ashenden MJ, et al. Detection of recombinant human erythropoietin abuse in athletes utilizing markers of altered erythropoiesis. Haematologica 2001; 86(2): 128–37PubMed
81.
go back to reference Nissen SL, Abumrad NN. Nutritional role of the leucine metabolite β-hydroxy-β-methylbutyrate (HMB). Nutr Biochem 1997; 8: 300–11CrossRef Nissen SL, Abumrad NN. Nutritional role of the leucine metabolite β-hydroxy-β-methylbutyrate (HMB). Nutr Biochem 1997; 8: 300–11CrossRef
82.
go back to reference Slater GJ, Jenkins D. Beta-hydroxy-beta-methylbutyrate (HMB) supplementation and the promotion of muscle growth and strength. Sports Med 2000; 30(2): 105–16PubMedCrossRef Slater GJ, Jenkins D. Beta-hydroxy-beta-methylbutyrate (HMB) supplementation and the promotion of muscle growth and strength. Sports Med 2000; 30(2): 105–16PubMedCrossRef
83.
go back to reference Knitter AE, Panton L, Rathmacher JA, et al. Effects of beta-hydroxy-beta-methylbutyrate on muscle damage after a prolonged run. J Appl Physiol 2000; 89(4): 1340–4PubMed Knitter AE, Panton L, Rathmacher JA, et al. Effects of beta-hydroxy-beta-methylbutyrate on muscle damage after a prolonged run. J Appl Physiol 2000; 89(4): 1340–4PubMed
84.
go back to reference Gallagher PM, Carrithers JA, Godard MP, et al. Beta-hydroxy-beta-methylbutyrate ingestion. Part I: effects on strength and fat free mass. Med Sci Sports Exerc 2000; 32(12): 2109–15PubMedCrossRef Gallagher PM, Carrithers JA, Godard MP, et al. Beta-hydroxy-beta-methylbutyrate ingestion. Part I: effects on strength and fat free mass. Med Sci Sports Exerc 2000; 32(12): 2109–15PubMedCrossRef
85.
go back to reference Panton LB, Rathmacher JA, Baier MS, et al. Nutritional supplementation of the leucine metabolit β-hydroxy-β-methylbutyrate (HMB) during resistance training. Nutrition 2000; 16: 734–9PubMedCrossRef Panton LB, Rathmacher JA, Baier MS, et al. Nutritional supplementation of the leucine metabolit β-hydroxy-β-methylbutyrate (HMB) during resistance training. Nutrition 2000; 16: 734–9PubMedCrossRef
86.
go back to reference Jowko E, Ostaszewski P, Jank M, et al. Creatine and betahydroxy-beta-methylbutyrate (HMB) additively increase lean body mass and muscle strength during a weight-training program. Nutrition 2001; 17(7–8): 558–66PubMedCrossRef Jowko E, Ostaszewski P, Jank M, et al. Creatine and betahydroxy-beta-methylbutyrate (HMB) additively increase lean body mass and muscle strength during a weight-training program. Nutrition 2001; 17(7–8): 558–66PubMedCrossRef
87.
go back to reference Slater G, Jenkins D, Logan P, et al. Beta-hydroxy-beta-methylbutyrate (HMB) supplementation does not affect changes in strength or body composition during resistance training in trained men. Int J Sport Nutr Exerc Metab 2001; 11(3): 384–96PubMed Slater G, Jenkins D, Logan P, et al. Beta-hydroxy-beta-methylbutyrate (HMB) supplementation does not affect changes in strength or body composition during resistance training in trained men. Int J Sport Nutr Exerc Metab 2001; 11(3): 384–96PubMed
88.
go back to reference Phillips SM, Tipton KD, Ferrando AA, et al. Resistance training reduces the acute exercise-induced increase in muscle protein turnover. Am J Physiol 1999; 276 (1 Pt 1): E118–24PubMed Phillips SM, Tipton KD, Ferrando AA, et al. Resistance training reduces the acute exercise-induced increase in muscle protein turnover. Am J Physiol 1999; 276 (1 Pt 1): E118–24PubMed
89.
go back to reference Gallagher PM, Carrithers JA, Godard MP, et al. Beta-hydroxy-beta-methylbutyrate ingestion. Part II: effects on hematology, hepatic and renal function. Med Sci Sports Exerc 2000; 32(12): 2116–9PubMedCrossRef Gallagher PM, Carrithers JA, Godard MP, et al. Beta-hydroxy-beta-methylbutyrate ingestion. Part II: effects on hematology, hepatic and renal function. Med Sci Sports Exerc 2000; 32(12): 2116–9PubMedCrossRef
90.
go back to reference Nissen S, Sharp RL, Panton L, et al. Beta-hydroxy-beta-methylbutyrate (HMB) supplementation in humans is safe and may decrease cardiovascular risk factors. J Nutr 2000; 130(8): 1937–45PubMed Nissen S, Sharp RL, Panton L, et al. Beta-hydroxy-beta-methylbutyrate (HMB) supplementation in humans is safe and may decrease cardiovascular risk factors. J Nutr 2000; 130(8): 1937–45PubMed
92.
go back to reference Rudman D, Feller AG, Nagraj HS, et al. Effects of human growth hormone in men over 60 years old. N Engl J Med 1990; 323(1): 1–6PubMedCrossRef Rudman D, Feller AG, Nagraj HS, et al. Effects of human growth hormone in men over 60 years old. N Engl J Med 1990; 323(1): 1–6PubMedCrossRef
93.
go back to reference De Palo EF, Gatti R, Lancerin F, et al. Correlations of growth hormone (GH) and insulin-like growth factor 1 (IGF-1): effects of exercise and abuse by athletes. Clin Chim Acta 2001; 305(1–2): 1–17PubMedCrossRef De Palo EF, Gatti R, Lancerin F, et al. Correlations of growth hormone (GH) and insulin-like growth factor 1 (IGF-1): effects of exercise and abuse by athletes. Clin Chim Acta 2001; 305(1–2): 1–17PubMedCrossRef
94.
go back to reference Jenkins PJ. Growth hormone and exercise: physiology, use and abuse. Growth Horm IGF Res 2001; 11Suppl. A: S71–7PubMedCrossRef Jenkins PJ. Growth hormone and exercise: physiology, use and abuse. Growth Horm IGF Res 2001; 11Suppl. A: S71–7PubMedCrossRef
96.
go back to reference Frisch H. Growth hormone and body composition in athletes. J Endocrinol Invest 1999; 22 (5 Suppl.): 106–9PubMed Frisch H. Growth hormone and body composition in athletes. J Endocrinol Invest 1999; 22 (5 Suppl.): 106–9PubMed
97.
go back to reference Johannsson G, Jorgensen JOL. Safety aspects of growth hormone replacement in adults. Growth Horm IGF Res 2001; 11(2): 59–71PubMedCrossRef Johannsson G, Jorgensen JOL. Safety aspects of growth hormone replacement in adults. Growth Horm IGF Res 2001; 11(2): 59–71PubMedCrossRef
98.
go back to reference Fryburg DA, Jahn LA, Hill SA, et al. Insulin and insulin-like growth factor-I enhance human skeletal muscle protein anabolism during hyperaminoacidemia by different mechanisms. J Clin Invest 1995; 96(4): 1722–9PubMedCrossRef Fryburg DA, Jahn LA, Hill SA, et al. Insulin and insulin-like growth factor-I enhance human skeletal muscle protein anabolism during hyperaminoacidemia by different mechanisms. J Clin Invest 1995; 96(4): 1722–9PubMedCrossRef
99.
go back to reference Yarasheski KE, Zachwieja JJ, Campbell JA, et al. Effect of growth hormone and resistance exercise on muscle growth and strength in older men. Am J Physiol 1995; 268 (2 Pt 1): E268–76PubMed Yarasheski KE, Zachwieja JJ, Campbell JA, et al. Effect of growth hormone and resistance exercise on muscle growth and strength in older men. Am J Physiol 1995; 268 (2 Pt 1): E268–76PubMed
100.
go back to reference Grimberg A, Cohen P. Role of insulin-like growth factors and their binding proteins in growth control and carcinogenesis. J Cell Physiol 2000; 183(1): 1–9PubMedCrossRef Grimberg A, Cohen P. Role of insulin-like growth factors and their binding proteins in growth control and carcinogenesis. J Cell Physiol 2000; 183(1): 1–9PubMedCrossRef
101.
go back to reference Lemon PW. Beyond the zone: protein needs of active individuals. J Am Coll Nutr 2000; 19 (5 Suppl.): 513S–21SPubMed Lemon PW. Beyond the zone: protein needs of active individuals. J Am Coll Nutr 2000; 19 (5 Suppl.): 513S–21SPubMed
102.
go back to reference Williams MH. Facts and fallacies of purported ergogenic amino acid supplements. Clin Sports Med 1999; 18(3): 633–49PubMedCrossRef Williams MH. Facts and fallacies of purported ergogenic amino acid supplements. Clin Sports Med 1999; 18(3): 633–49PubMedCrossRef
103.
go back to reference Tarnopolsky MA, Atkinson SA, MacDougall JD, et al. Evaluation of protein requirements for trained strength athletes. J Appl Physiol 1992; 73(5): 1986–95PubMed Tarnopolsky MA, Atkinson SA, MacDougall JD, et al. Evaluation of protein requirements for trained strength athletes. J Appl Physiol 1992; 73(5): 1986–95PubMed
104.
go back to reference Lemon PW, Tarnopolsky MA, MacDougall JD, et al. Protein requirements and muscle mass/strength changes during intensive training in novice bodybuilders. J Appl Physiol 1992; 73(2): 767–75PubMed Lemon PW, Tarnopolsky MA, MacDougall JD, et al. Protein requirements and muscle mass/strength changes during intensive training in novice bodybuilders. J Appl Physiol 1992; 73(2): 767–75PubMed
105.
go back to reference Williams AG, van den Oord M, Sharma A, et al. Is glucose/ amino acid supplementation after exercise an aid to strength training? Br J Sports Med 2001; 35(2): 109–13PubMedCrossRef Williams AG, van den Oord M, Sharma A, et al. Is glucose/ amino acid supplementation after exercise an aid to strength training? Br J Sports Med 2001; 35(2): 109–13PubMedCrossRef
106.
go back to reference Jentjens RL, van Loon LJ, Mann CH, et al. Addition of protein and amino acids to carbohydrates does not enhance post-exercise muscle glycogen synthesis. J Appl Physiol 2001; 91(2): 839–46PubMed Jentjens RL, van Loon LJ, Mann CH, et al. Addition of protein and amino acids to carbohydrates does not enhance post-exercise muscle glycogen synthesis. J Appl Physiol 2001; 91(2): 839–46PubMed
107.
go back to reference Davis JM, Welsh RS, De Volve KL, et al. Effects of branched-chain amino acids and carbohydrate on fatigue during intermittent, high-intensity running. Int J Sports Med 1999; 20(5): 309–14PubMedCrossRef Davis JM, Welsh RS, De Volve KL, et al. Effects of branched-chain amino acids and carbohydrate on fatigue during intermittent, high-intensity running. Int J Sports Med 1999; 20(5): 309–14PubMedCrossRef
108.
go back to reference Coombes JS, McNaughton LR. Effects of branched-chain amino acid supplementation on serum creatine kinase and lactate dehydrogenase after prolonged exercise. J Sports Med Phys Fitness 2000; 40(3): 240–6PubMed Coombes JS, McNaughton LR. Effects of branched-chain amino acid supplementation on serum creatine kinase and lactate dehydrogenase after prolonged exercise. J Sports Med Phys Fitness 2000; 40(3): 240–6PubMed
109.
go back to reference Mourier A, Bigard AX, de Kerviler E, et al. Combined effects of caloric restriction and branched-chain amino acid supplementation on body composition and exercise performance in elite wrestlers. Int J Sports Med 1997; 18(1): 47–55PubMedCrossRef Mourier A, Bigard AX, de Kerviler E, et al. Combined effects of caloric restriction and branched-chain amino acid supplementation on body composition and exercise performance in elite wrestlers. Int J Sports Med 1997; 18(1): 47–55PubMedCrossRef
110.
go back to reference Wagenmakers AJ. Amino acid supplements to improve athletic performance. Curr Opin Clin Nutr Metab Care 1999; 2(6): 539–44PubMedCrossRef Wagenmakers AJ. Amino acid supplements to improve athletic performance. Curr Opin Clin Nutr Metab Care 1999; 2(6): 539–44PubMedCrossRef
111.
go back to reference Stanko RT, Robertson RJ, Galbreath RW, et al. Enhanced leg exercise endurance with a high-carbohydrate diet and dihydroxyacetone and pyruvate. J Appl Physiol 1990; 69(5): 1651–6PubMed Stanko RT, Robertson RJ, Galbreath RW, et al. Enhanced leg exercise endurance with a high-carbohydrate diet and dihydroxyacetone and pyruvate. J Appl Physiol 1990; 69(5): 1651–6PubMed
112.
go back to reference Stanko RT, Robertson RJ, Spina RJ, et al. Enhancement of arm exercise endurance capacity with dihydroxyacetone and pyruvate. J Appl Physiol 1990; 68(1): 119–24PubMed Stanko RT, Robertson RJ, Spina RJ, et al. Enhancement of arm exercise endurance capacity with dihydroxyacetone and pyruvate. J Appl Physiol 1990; 68(1): 119–24PubMed
113.
go back to reference Morrison MA, Spriet LL, Dyck DJ. Pyruvate ingestion for 7 days does not improve aerobic performance in well-trained individuals. J Appl Physiol 2000; 89(2): 549–56PubMed Morrison MA, Spriet LL, Dyck DJ. Pyruvate ingestion for 7 days does not improve aerobic performance in well-trained individuals. J Appl Physiol 2000; 89(2): 549–56PubMed
114.
go back to reference Sukala WR. Pyruvate: beyond the marketing hype. Int J Sport Nutr 1998; 8(3): 241–9PubMed Sukala WR. Pyruvate: beyond the marketing hype. Int J Sport Nutr 1998; 8(3): 241–9PubMed
115.
go back to reference Earnest CP. Dietary androgen supplements: separating substance from hype. Phys Sports Med 2001; 29(5): 63–79 Earnest CP. Dietary androgen supplements: separating substance from hype. Phys Sports Med 2001; 29(5): 63–79
116.
go back to reference Leder BZ, Catlin DH, Longcope C, et al. Metabolism of orally administered androstenedione in young men. J Clin Endocrinol Metab 2001; 86(8): 3654–8PubMedCrossRef Leder BZ, Catlin DH, Longcope C, et al. Metabolism of orally administered androstenedione in young men. J Clin Endocrinol Metab 2001; 86(8): 3654–8PubMedCrossRef
117.
go back to reference Leder BZ, Longcope C, Catlin DH, et al. Oral androstenedione administration and serum testosterone concentrations in young men. JAMA 2000; 283(6): 779–82PubMedCrossRef Leder BZ, Longcope C, Catlin DH, et al. Oral androstenedione administration and serum testosterone concentrations in young men. JAMA 2000; 283(6): 779–82PubMedCrossRef
118.
go back to reference King DS, Sharp RL, Vukovich MD, et al. Effect of oral androstenedione on serum testosterone and adaptations to resistance training in young men: a randomized controlled trial. JAMA 1999; 281(21): 2020–8PubMedCrossRef King DS, Sharp RL, Vukovich MD, et al. Effect of oral androstenedione on serum testosterone and adaptations to resistance training in young men: a randomized controlled trial. JAMA 1999; 281(21): 2020–8PubMedCrossRef
119.
go back to reference Broeder CE, Quindry J, Brittingham K, et al. The Andro Project: physiological and hormonal influences of androstenedione supplementation in men 35 to 65 years old participating in a high-intensity resistance training program. Arch Intern Med 2000; 160(20): 3093–104PubMedCrossRef Broeder CE, Quindry J, Brittingham K, et al. The Andro Project: physiological and hormonal influences of androstenedione supplementation in men 35 to 65 years old participating in a high-intensity resistance training program. Arch Intern Med 2000; 160(20): 3093–104PubMedCrossRef
120.
go back to reference Rasmussen BB, Volpi E, Gore DC, et al. Androstenedione does not stimulate muscle protein anabolism in young healthy men. J Clin Endocrinol Metab 2000; 85(1): 55–9PubMedCrossRef Rasmussen BB, Volpi E, Gore DC, et al. Androstenedione does not stimulate muscle protein anabolism in young healthy men. J Clin Endocrinol Metab 2000; 85(1): 55–9PubMedCrossRef
121.
go back to reference Catlin DH, Leder BZ, Ahrens B, et al. Trace contamination of over-the-counter androstenedione and positive urine test results for a nandrolone metabolite. JAMA 2000; 284(20): 2618–21PubMedCrossRef Catlin DH, Leder BZ, Ahrens B, et al. Trace contamination of over-the-counter androstenedione and positive urine test results for a nandrolone metabolite. JAMA 2000; 284(20): 2618–21PubMedCrossRef
122.
go back to reference Brown GA, Vukovich MD, Reifenrath TA, et al. Effects of anabolic precursors on serum testosterone concentrations and adaptations to resistance training in young men. Int J Sport Nutr Exerc Metab 2000; 10(3): 340–59PubMed Brown GA, Vukovich MD, Reifenrath TA, et al. Effects of anabolic precursors on serum testosterone concentrations and adaptations to resistance training in young men. Int J Sport Nutr Exerc Metab 2000; 10(3): 340–59PubMed
123.
go back to reference Brown GA, Vukovich MD, Sharp RL, et al. Effect of oral DHEA on serum testosterone and adaptations to resistance training in young men. J Appl Physiol 1999; 87(6): 2274–83PubMed Brown GA, Vukovich MD, Sharp RL, et al. Effect of oral DHEA on serum testosterone and adaptations to resistance training in young men. J Appl Physiol 1999; 87(6): 2274–83PubMed
124.
go back to reference Abramowicz M, editor. Dehydroepiandrosterone (DHEA). Med Lett Drugs Ther 1996; 38(985): 91–2 Abramowicz M, editor. Dehydroepiandrosterone (DHEA). Med Lett Drugs Ther 1996; 38(985): 91–2
125.
go back to reference Shahidi NT. A review of the chemistry, biological action, and clinical applications of anabolic-androgenic steroids. Clin Ther 2001; 23(9): 1355–90PubMedCrossRef Shahidi NT. A review of the chemistry, biological action, and clinical applications of anabolic-androgenic steroids. Clin Ther 2001; 23(9): 1355–90PubMedCrossRef
126.
go back to reference Bahrke MS, Yesalis CE, Kopstein AN, et al. Risk factors associated with anabolic-androgenic steroid use among adolescents. Sports Med 2000; 29(6): 397–405PubMedCrossRef Bahrke MS, Yesalis CE, Kopstein AN, et al. Risk factors associated with anabolic-androgenic steroid use among adolescents. Sports Med 2000; 29(6): 397–405PubMedCrossRef
127.
go back to reference Kutscher EC, Lund BC, Perry PJ. Anabolic steroids: a review for the clinician. Sports Med 2002; 32(5): 285–96PubMedCrossRef Kutscher EC, Lund BC, Perry PJ. Anabolic steroids: a review for the clinician. Sports Med 2002; 32(5): 285–96PubMedCrossRef
128.
129.
go back to reference Griggs RC, Kingston W, Jozefowicz RF, et al. Effect of testosterone on muscle mass and muscle protein synthesis. J Appl Physiol 1989; 66(1): 498–503PubMed Griggs RC, Kingston W, Jozefowicz RF, et al. Effect of testosterone on muscle mass and muscle protein synthesis. J Appl Physiol 1989; 66(1): 498–503PubMed
130.
go back to reference Tamaki T, Uchiyama S, Uchiyama Y, et al. Anabolic steroids increase exercise tolerance. Am J Physiol Endocrinol Metab 2001; 280(6): E973–81PubMed Tamaki T, Uchiyama S, Uchiyama Y, et al. Anabolic steroids increase exercise tolerance. Am J Physiol Endocrinol Metab 2001; 280(6): E973–81PubMed
131.
go back to reference Fenichel GM, Griggs RC, Kissel J, et al. A randomized efficacy and safety trial of oxandrolone in the treatment of Duchenne dystrophy. Neurology 2001 Apr 24; 56(8): 1075–9PubMedCrossRef Fenichel GM, Griggs RC, Kissel J, et al. A randomized efficacy and safety trial of oxandrolone in the treatment of Duchenne dystrophy. Neurology 2001 Apr 24; 56(8): 1075–9PubMedCrossRef
132.
go back to reference Dickerman RD, Pertusi RM, Zachariah NY, et al. Anabolic steroid-induced hepatotoxicity: is it overstated? Clin J Sport Med 1999; 9(1): 34–9PubMedCrossRef Dickerman RD, Pertusi RM, Zachariah NY, et al. Anabolic steroid-induced hepatotoxicity: is it overstated? Clin J Sport Med 1999; 9(1): 34–9PubMedCrossRef
133.
go back to reference Torres-Calleja J, Gonzalez-Unzaga M, DeCelis-Carrillo R, et al. Effect of androgenic anabolic steroids on sperm quality and serum hormone levels in adult male bodybuilders. Life Sci 2001; 68(15): 1769–74PubMedCrossRef Torres-Calleja J, Gonzalez-Unzaga M, DeCelis-Carrillo R, et al. Effect of androgenic anabolic steroids on sperm quality and serum hormone levels in adult male bodybuilders. Life Sci 2001; 68(15): 1769–74PubMedCrossRef
134.
go back to reference Kindlundh AM, Hagekull B, Isacson DG, et al. Adolescent use of anabolic-androgenic steroids and relations to self-reports of social, personality and health aspects. Eur J Public Health 2001; 11(3): 322–8PubMedCrossRef Kindlundh AM, Hagekull B, Isacson DG, et al. Adolescent use of anabolic-androgenic steroids and relations to self-reports of social, personality and health aspects. Eur J Public Health 2001; 11(3): 322–8PubMedCrossRef
135.
go back to reference Nilsson S, Baigi A, Marklund B, et al. Trends in the misuse of androgenic anabolic steroids among boys 16–17 years old in a primary health care area in Sweden. Scand J Prim Health Care 2001; 19(3): 181–2PubMedCrossRef Nilsson S, Baigi A, Marklund B, et al. Trends in the misuse of androgenic anabolic steroids among boys 16–17 years old in a primary health care area in Sweden. Scand J Prim Health Care 2001; 19(3): 181–2PubMedCrossRef
136.
go back to reference Green GA, Catlin DH, Starcevic B. Analysis of over-the-counter dietary supplements. Clin J Sport Med 2001; 11(4): 254–9PubMedCrossRef Green GA, Catlin DH, Starcevic B. Analysis of over-the-counter dietary supplements. Clin J Sport Med 2001; 11(4): 254–9PubMedCrossRef
Metadata
Title
Popular Sports Supplements and Ergogenic Aids
Author
Mark S. Juhn
Publication date
01-10-2003
Publisher
Springer International Publishing
Published in
Sports Medicine / Issue 12/2003
Print ISSN: 0112-1642
Electronic ISSN: 1179-2035
DOI
https://doi.org/10.2165/00007256-200333120-00004