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Sports Medicine
Published in: Sports Medicine 6/2000

01-06-2000 | Review Article

Oxidation of Carbohydrate Feedings During Prolonged Exercise

Current Thoughts, Guidelines and Directions for Future Research

Authors: Dr Asker E. Jeukendrup, Roy Jentjens

Published in: Sports Medicine | Issue 6/2000

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Abstract

Although it is known that carbohydrate (CHO) feedings during exercise improve endurance performance, the effects of different feeding strategies are less clear. Studies using (stable) isotope methodology have shown that not all carbohydrates are oxidised at similar rates and hence they may not be equally effective. Glucose, sucrose, maltose, maltodextrins and amylopectin are oxidised at high rates. Fructose, galactose and amylose have been shown to be oxidised at 25 to 50% lower rates. Combinations of multiple transportable CHO may increase the total CHO absorption and total exogenous CHO oxidation. Increasing the CHO intake up to 1.0 to 1.5 g/min will increase the oxidation up to about 1.0 to 1.1 g/min. However, a further increase of the intake will not further increase the oxidation rates. Training status does not affect exogenous CHO oxidation. The effects of fasting and muscle glycogen depletion are less clear.
The most remarkable conclusion is probably that exogenous CHO oxidation rates do not exceed 1.0 to 1.1 g/min. There is convincing evidence that this limitation is not at the muscular level but most likely located in the intestine or the liver. Intestinal perfusion studies seem to suggest that the capacity to absorb glucose is only slightly in excess of the observed entrance of glucose into the blood and the rate of absorption may thus be a factor contributing to the limitation. However, the liver may play an additional important role, in that it provides glucose to the bloodstream at a rate of about 1 g/min by balancing the glucose from the gut and from glycogenolysis/gluconeogenesis. It is possible that when large amounts of glucose are ingested absorption is a limiting factor, and the liver will retain some glucose and thus act as a second limiting factor to exogenous CHO oxidation.
Literature
1.
Jeukendrup AE, Brouns F, Wagenmakers AJM, et al. Carbohydrate feedings improve 1 h time trial cycling performance. Int J Sports Med 1997; 18: 125–9PubMedCrossRef
2.
Coyle EF, Coggan AR, Hemmert MK, et al. Muscle glycogen utilization during prolonged strenuous exercise when fed carbohydrate. J Appl Physiol 1986; 61: 165–72PubMed
3.
Bosch AN, Dennis SC, Noakes TD. Influence of carbohydrate ingestion on fuel substrate turnover and oxidation during prolonged exercise. J Appl Physiol 1994; 76: 2364–72PubMed
4.
McConnell G, Fabris S, Proietto J, et al. Effect of carbohydrate ingestion on glucose kinetics during exercise. J Appl Physiol 1994; 77 (3): 1537–41
5.
Jeukendrup AE, Wagenmakers AJ, Stegen JH, et al. Carbohydrate ingestion can completely suppress endogenous glucose production during exercise. Am J Physiol 1999; 276: E672–83
6.
Tsintzas OK, Williams C, Boobis L, et al. Carbohydrate ingestion and single muscle fiber glycogen metabolism during prolonged running in men. J Appl Physiol 1996; 81: 801–9PubMed
7.
Tsintzas OK, Williams C, Boobis L, et al. Carbohydrate ingestion and glycogen utilisation in different muscle fibre types in man. J Physiol 1995; 489: 243–50PubMed
8.
Jeukendrup AE, Raben A, Gijsen A, et al. Glucose kinetics during prolonged exercise in highly trained human subjects: effect of glucose ingestion. J Physiol (Lond) 1999; 515: 579–89CrossRef
9.
Tsintzas K, Williams C. Human muscle glycogen metabolism during exercise: effect of carbohydrate supplementation. Sports Med 1998; 25: 7–23PubMedCrossRef
10.
Costill DL, Bennett A, Branam G, et al. Glucose ingestion at rest and during prolonged exercise. J Appl Physiol 1973; 34: 764–9PubMed
11.
Beckers EJ, Halliday D, Wagenmakers AJ. Glucose metabolism and radioactive labeling: what are the real dangers? Med Sci Sports Exerc 1994; 26: 1316–8PubMed
12.
Robert JJ, Koziet J, Chauvet D, et al. Use of 13C-labeled glucose for estimating glucose oxidation: some design considerations. J Appl Physiol 1987; 63: 1725–32PubMed
13.
Sidossis LS, Coggan AR, Gastaldelli A, et al. A new correction factor for use in tracer estimations of plasma fatty acid oxidation. Am J Physiol 1995; 269: E649–56
14.
Jeukendrup AE, Wagenmakers AJM, Brouns F, et al. Effects of carbohydrate (CHO) and fat supplementation on CHO metabolism during prolonged exercise. Metabolism 1996; 45: 915–21PubMedCrossRef
15.
Sidossis LS, Coggan AR, Gastadelli A, et al. Pathways of free fatty acid oxidation in human subjects: implications for tracer studies. J Clin Invest 1995; 95: 278–84PubMedCrossRef
16.
Schrauwen P, van Aggel-Leijssen DP, van Marken Lichtenbelt WD, et al. Validation of the [1,2–13C]acetate recovery factor for correction of [U-13C]palmitate oxidation rates in humans. J Physiol (Lond) 1998; 513: 215–23CrossRef
17.
Péronnet F, Massicotte D, Brisson G, et al. Use of 13C substrates for metabolic studies in exercise: methodological considerations. J Appl Physiol 1990; 69: 1047–52PubMed
18.
Wagenmakers AJM, Rehrer NJ, Brouns F, et al. Breath 13CO2 background enrichment at rest and during exercise: diet related differences between Europe and America. J Appl Physiol 1993; 74: 2353–7PubMed
19.
Jandrain BJ, Pirnay F, Lacroix M, et al. Effect of osmolality on availability of glucose ingested during prolonged exercise in humans. J Appl Physiol 1989; 67: 76–82PubMed
20.
Krzentowski G, Jandrain B, Pirnay F, et al. Availability of glucose given orally during exercise. J Appl Physiol 1984; 56: 315–20PubMed
21.
Pirnay F, Lacroix M, Mosora F, et al. Effect of glucose ingestion on energy substrate utilization during prolonged exercise in man. Eur J Appl Physiol 1977; 36: 1620–4CrossRef
22.
Pirnay F, Lacroix M, Mosora F, et al. Glucose oxidation during prolonged exercise evaluated with naturally labelled [13C] glucose. J Appl Physiol 1977; 43: 258–61
23.
Guezennec CY, Satabin P, Duforez F, et al. Oxidation of corn starch, glucose, and fructose ingested before exercise. Med Sci Sports Exerc 1989; 21: 45–50PubMedCrossRef
24.
Burelle Y, Péronnet F, Charpentier S, et al. Oxidation of an oral [13C]glucose load at rest and prolonged exercise in trained and sedentary subjects. J Appl Physiol 1999; 86: 52–60PubMed
25.
Massicotte D, Péronnet F, Brisson G, et al. Oxidation of exogenous carbohydrate during prolonged exercise in fed and fasted conditions. Int J Sports Med 1990; 11: 253–8PubMedCrossRef
26.
Massicotte D, Péronnet F, Brisson G, et al. Oxidation of a glucose polymer during exercise: comparison with glucose and fructose. J Appl Physiol 1989; 66: 179–83PubMed
27.
Moodley D, Noakes TD, Bosch AN, et al. Oxidation of exogenous carbohydrate during prolonged exercise: the effects of the carbohydrate type and its concentration. Eur J Appl Physiol 1992; 64: 328–34CrossRef
28.
Massicotte D, Péronnet F, Adopo E, et al. Effect of metabolic rate on the oxidation of ingested glucose and fructose during exercise. Int J Sports Med 1994; 15: 177–80PubMedCrossRef
29.
Rehrer NJ, Brouns F, Beckers EJ, et al. Gastric emptying with repeated drinking during running and bicycling. Int J Sports Med 1990; 11: 238–43PubMedCrossRef
30.
Noakes TD, Rehrer NJ, Maughan RJ. The importance of volume in regulating gastric emptying. Med Sci Sports Exerc 1991; 23: 307–13PubMed
31.
Rehrer NJ, Wagenmakers AJM, Beckers EJ, et al. Gastric emptying, absorption and carbohydrate oxidation during prolonged exercise. J Appl Physiol 1992; 72: 468–75PubMed
32.
McConell G, Kloot K, Hargreaves M. Effect of timing of carbohydrate ingestion on endurance exercise performance. Med Sci Sports Exerc 1996; 28 (10): 1300–4PubMedCrossRef
33.
Massicotte D, Péronnet F, Allah C, et al. Metabolic response to [13C] glucose and [13C] fructose ingestion during exercise. J Appl Physiol 1986; 61: 1180–4PubMed
34.
Décombaz J, Sartori D, Arnaud M-J, et al. Oxidation and metabolic effects of fructose and glucose ingested before exercise. Int J Sports Med 1985; 6: 282–6PubMedCrossRef
35.
Leijssen DPC, Saris WHM, Jeukendrup AE, et al. Oxidation of orally ingested [13C]-glucose and [13C]-galactose during exercise. J Appl Physiol 1995; 79: 720–5PubMed
36.
Hawley JA, Dennis SC, Nowitz A, et al. Exogenous carbohydrate oxidation from maltose and glucose ingested during prolonged exercise. Eur J Appl Physiol 1992; 64: 523–7CrossRef
37.
Wagenmakers AJM, Brouns F, Saris WHM, et al. Oxidation rates of orally ingested carbohydrates during prolonged exercise in man. J Appl Physiol 1993; 75: 2774–80PubMed
38.
Saris WHM, Goodpaster BH, Jeukendrup AE, et al. Exogenous carbohydrate oxidation from different carbohydrate sources during exercise. J Appl Physiol 1993; 75: 2168–72PubMed
39.
Okano G, Takeda H, Morita I, et al. Effect of pre-exercise fructose ingestion on endurance performance in fed man. Med Sci Sports Exerc 1988; 20: 105–9PubMedCrossRef
40.
Koivisto VA, Karonen S-L, Nikkila EA. Carbohydrate ingestion before exercise: comparison of glucose, fructose and placebo. J Appl Physiol 1981; 51: 783–7PubMed
41.
Samols E, Dormandy TL. Insulin response to fructose and galactose. Lancet 1963; I: 478–9CrossRef
42.
Jandrain BJ, Pallikarakis N, Normand S, et al. Fructose utilization during exercise in men: rapid conversion of ingested fructose to circulating glucose. J Appl Physiol 1993; 74: 2146–54PubMedCrossRef
43.
Burelle Y, Péronnet F, Massicotte D, et al. Oxidation of 13C-glucose and 13C-fructose ingested as a preexercise meal: effect of carbohydrate ingestion during exercise. Int J Sport Nutr 1997; 7: 117–27PubMed
44.
Adopo E, Péronnet F, Massicotte D, et al. Respective oxidation of exogenous glucose and fructose given in the same drink during exercise. J Appl Physiol 1994; 76: 1014–9PubMed
45.
Jeukendrup AE, Borghouts L, Saris WHM, et al. Reduced oxidation rates of orally ingested glucose during exercise after low CHO intake and low muscle glycogen. J Appl Physiol 1996; 81: 1952–7PubMed
46.
Hawley JA, Dennis SC, Laidler BJ, et al. High rates of exogenous carbohydrate oxidation from starch ingested during prolonged exercise. J Appl Physiol 1991; 71: 1801–6PubMed
47.
Shi X, Summers R, Schedl H, et al. Effects of carbohydrate type and concentration and solution osmolality on water absorption. Med Sci Sports Exerc 1995; 27: 1607–15PubMed
48.
Brouns F, Senden J, Beckers EJ, et al. Osmolarity does not affect the gastric emptying rate of oral rehydration solutions. J Parent Enter Nutr 1995; 19: 403–6CrossRef
49.
Shi X, Gisolfi CV. Fluid and carbohydrate replacement during intermittent exercise. Sports Med 1998; 25: 157–72PubMedCrossRef
50.
Brouns F, Beckers E. Is the gut an athletic organ? Digestion, absorption and exercise. Sports Med 1993; 15: 242–57PubMedCrossRef
51.
Pallikarakis N, Jandrain B, Pirnay F, et al. Remarkable metabolic availability of oral glucose during long-duration exercise in humans. J Appl Physiol 1986; 60: 1035–42PubMed
52.
Romijn JA, Coyle EF, Sidossis LS, et al. Regulation of endogenous fat and carbohydrate metabolism in relation to exercise intensity. Am J Physiol 1993; 265: E380–91
53.
Pirnay F, Crielaard JM, Pallikarakis N, et al. Fate of exogenous glucose during exercise of different intensities in humans. J Appl Physiol 1982; 53: 1620–4PubMed
54.
Pirnay F, Scheen AJ, Gautier JF, et al. Exogenous glucose oxidation during exercise in relation to the power output. Int J Sports Med 1995; 16: 456–60PubMedCrossRef
55.
van Loon LJ, Jeukendrup AE, Saris WH, et al. Effect of training status on fuel selection during submaximal exercise with glucose ingestion. J Appl Physiol 1999; 87: 1413–20PubMed
56.
Kuipers H, Saris WHM, Brouns F, et al. Glycogen synthesis during exercise and rest with carbohydrate feeding in males and females. Int J Sports Med 1989; 10: S63–7CrossRef
57.
Ravussin E, Pahud P, Dorner A, et al. Substrate utilization during prolonged exercise preceded by ingestion of 13C-glucose in glycogen depleted and control subjects. Pflügers Arch 1979; 382: 197–202PubMedCrossRef
58.
Péronnet F, Rheaume N, Lavoie C, et al. Oral [13C]glucose oxidation during prolonged exercise after high- and low-carbohydrate diets. J Appl Physiol 1998; 85 (2): 723–30PubMed
59.
Kuipers H, Keizer HA, Brouns F, et al. Carbohydrate feeding and glycogen synthesis during exercise in man. Pflügers Arch 1987; 410: 652–6PubMedCrossRef
60.
Hargreaves M, Kiens B, Richter EA. Effect of increased plasma free fatty acid concentrations on muscle metabolism in exercising men. J Appl Physiol 1991; 70: 194–201PubMed
61.
Bergman BC, Butterfield GE, Wolfel EE, et al. Muscle net glucose uptake and glucose kinetics after endurance training in men. Am J Physiol 1999; 277: E81–92
62.
Friedlander AL, Casazza GA, Horning MA, et al. Training induced alterations of glucose flux in men. J Appl Physiol 1997; 82: 1360–9PubMed
63.
Coggan AR, Kohrt WM, Spina RJ, et al. Plasma glucose kinetics during exercise in subjects with high and low lactate thresholds. J Appl Physiol 1992; 73: 1873–80PubMed
64.
Coggan AR, Raguso CA, Williams BD, et al. Glucose kinetics during high-intensity exercise in endurance-trained and untrained humans. J Appl Physiol 1995; 78: 1203–7PubMedCrossRef
65.
Janssen E, Kaijser L. Substrate utilization and enzymes in skeletal muscle of extremely endurance-trained men. J Appl Physiol 1987; 62: 999–1005
66.
Richter EA, Kiens B, Saltin B, et al. Skeletal muscle glucose uptake during dynamic exercise in humans: role of muscle mass. Am J Physiol 1988; 254: E555–61
67.
Dela F, Mikines KJ, von Linstow M, et al. Effect of training on insulin-mediated glucose uptake in human muscle. Am J Physiol 1992; 263: E1134–43
68.
Krzentowski GB, Pirnay F, Luyckx AS, et al. Effect of physical training on utilization of a glucose load given orally during exercise. Am J Physiol 1984; 246: E412–7
69.
Jeukendrup AE, Mensink M, Saris WHM, et al. Exogenous glucose oxidation during exercise in endurance-trained and untrained subjects. J Appl Physiol 1997; 82: 835–40PubMed
70.
Jeukendrup AE, Vet-Joop K, Sturk A, et al. Relationship between gastro-intestinal complaints and endotoxaemia, cytokine release and the acute-phase reaction during and after a long-distance triathlon in highly trained men. Clin Sci (Colch) 2000; 98: 47–55CrossRef
71.
Greiwe JS, Hickner RC, Hansen PA, et al. Effects of endurance exercise training on muscle glycogen accumulation in humans. J Appl Physiol 1999; 87: 222–6PubMed
72.
Duchman SM, Ryan AJ, Schedl HP, et al. Upper limit for intestinal absorption of a dilute glucose solution in men at rest. Med Sci Sports Exerc 1997; 29: 482–8PubMedCrossRef
73.
Hawley JA, Bosch AN, Weltan SM, et al. Glucose kinetics during prolonged exercise in euglycemic and hyperglycemic subjects. Pflügers Arch 1994; 426: 378–86PubMedCrossRef
74.
Mandarino LJ, Consoli A, Jain A, et al. Differential regulation of intracellular glucose metabolism by glucose and insulin in human muscle. Am J Physiol 1993; 265: E898–905
75.
Postic C, Burcelin R, Rencurel F, et al. Evidence for a transient inhibitory effect of insulin on GLUT2 expression in the liver: studies in vivo and in vitro. Biochem J 1993; 293: 119–24PubMed
76.
Iynedjian PB, Gjinovci A, Renold AE. Stimulation by insulin of glucokinase gene transcription in liver of diabetic rats. J Biol Chem 1988; 263: 740–4PubMed
77.
Al-Habori M, Peak M, Thomas TH, et al. The role of cell swelling in the stimulation of glycogen synthesis by insulin. Biochem J 1992; 282: 789–96PubMed
78.
Casey A, Mann R, Banister K, et al. Effect of carbohydrate ingestion on glycogen resynthesis in human liver and skeletal muscle, measured by (13)C MRS. Am J Physiol Endocrinol Metab 2000; 278 (1): E65–75
79.
Anantaraman R, Cannines AA, Gaesser GA, et al. Effects of carbohydrate supplementation on performance during 1 h of high intensity exercise. Int J Sports Med 1995; 16: 461–5PubMedCrossRef
80.
Below PR, Mora-Rodríguez R, Gonzáles Alonso J, et al. Fluid and carbohydrate ingestion independently improve performance during 1 h of intense exercise. Med Sci Sports Exerc 1995; 27: 200–10PubMed
81.
Febbraio MA, Snow RJ, Hargreaves M, et al. Muscle metabolism during exercise and heat stress in trained men: effect of acclimation. J Appl Physiol 1994; 76: 589–97PubMed
82.
Hargreaves M, Angus D, Howlett K, et al. Effect of heat stress on glucose kinetics during exercise. J Appl Physiol 1996; 81: 1594–7PubMed
83.
Johnson JM, Park MK. Reflex control of skin blood flow by skin temperature: role of core temperature. J Appl Physiol 1979; 47: 1188–93PubMed
84.
Williams JH, Mager M, Jacobson ED. Relationship of mesenteric blood flow to intestinal absorption of carbohydrates. J Lab Clin Med 1964; 63: 853–63PubMed
85.
Clausen JP. Effect of physical training on cardiovascular adjustments to exercise in man. Physiol Rev 1977; 57: 779–815PubMed
86.
Febbraio M, Murton P, Selig S, et al. Effect of CHO ingestion on exercise metabolism and performance in different ambient temperatures. Med Sci Sports Exerc 1996; 28: 1380–7PubMedCrossRef
87.
Davis JM, Lamb DR, Pate RR, et al. Carbohydrate-electrolyte drinks: effects on endurance cycling in the heat. Am J Clin Nutr 1988; 48: 1023–30PubMed
88.
Millard-Stafford M, Sparling PB, Rosskopf LB, et al. Carbohydrate-electrolyte replacement during a simulated triathlon in the heat. Med Sci Sports Exerc 1990; 22: 621–8PubMedCrossRef
Metadata
Title
Oxidation of Carbohydrate Feedings During Prolonged Exercise
Current Thoughts, Guidelines and Directions for Future Research
Authors
Dr Asker E. Jeukendrup
Roy Jentjens
Publication date
01-06-2000
Publisher
Springer International Publishing
Published in
Sports Medicine / Issue 6/2000
Print ISSN: 0112-1642
Electronic ISSN: 1179-2035
DOI
https://doi.org/10.2165/00007256-200029060-00004

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