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26-08-2022 | Cytostatic Therapy | ASO Author Reflections

ASO Author Reflections: Challenges in the Management of Bowel Obstruction after Cytoreductive Surgery and Heated Intraperitoneal Chemotherapy

Authors: Eyal Mor, MD, Shachar Laks, MD, Aviram Nissan, MD, Mohammad Adileh, MD

Published in: Annals of Surgical Oncology | Issue 13/2022

Excerpt

Patients with peritoneal metastasis have limited treatment options. Cytoreductive surgery and heated intraperitoneal chemotherapy (CRS/HIPEC) was shown to be an effective surgical treatment option for the management of these patients.^1,2 One underreported complication of CRS/HIPEC is bowel obstruction, which can be divided on the basis of etiology into adhesive/benign or malignant. The management of these patients, whether conservative or surgical, is complex. Benign obstructions may be managed according to known guidelines.³ However, the management of malignant obstructions requires a different approach. Treatment paradigms for the management of such patients are lacking owing to the paucity of data on the outcomes of surgical and conservative management of these patients. …

Verwaal VJ, Bruin S, Boot H, van Slooten G, van Tinteren H. 8-Year follow-up of randomized trial: cytoreduction and hyperthermic intraperitoneal chemotherapy versus systemic chemotherapy in patients with peritoneal carcinomatosis of colorectal cancer. Ann Surg Oncol. 2008;15(9):2426–32. https://doi.org/10.1245/s10434-008-9966-2.CrossRefPubMed

Quenet F, Elias D, Roca L, et al. A UNICANCER phase III trial of hyperthermic intra-peritoneal chemotherapy (HIPEC) for colorectal peritoneal carcinomatosis. PRODIGE 7. Eur J Surg Oncol. 2019;45(2):e17. https://doi.org/10.1016/j.ejso.2018.10.086.

ten Broek RPG, Krielen P, di Saverio S, et al. Bologna guidelines for diagnosis and management of adhesive small bowel obstruction (ASBO): 2017 update of the evidence-based guidelines from the world society of emergency surgery ASBO working group. World J Emerg Surg. 2018;13(1):24. https://doi.org/10.1186/s13017-018-0185-2.CrossRefPubMedPubMedCentral

Mor E, Shanie S, Adileh M, et al. Natural history and management of small bowel obstruction in patients after cytoreductive surgery and intraperitoneal chemotherapy. Ann Surg Oncol. 2022. https://doi.org/10.1245/s10434-022-12370-x.CrossRefPubMed

Title: ASO Author Reflections: Challenges in the Management of Bowel Obstruction after Cytoreductive Surgery and Heated Intraperitoneal Chemotherapy
Authors: Eyal Mor, MD
Shachar Laks, MD
Aviram Nissan, MD
Mohammad Adileh, MD
Publication date: 26-08-2022
Publisher: Springer International Publishing
Keyword: Cytostatic Therapy
Published in: Annals of Surgical Oncology / Issue 13/2022
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI: https://doi.org/10.1245/s10434-022-12439-7

At a glance: The STEP trials

Springer Medicine

ASO Author Reflections: Challenges in the Management of Bowel Obstruction after Cytoreductive Surgery and Heated Intraperitoneal Chemotherapy

Excerpt

At a glance: The STEP trials

Springer Medicine

Excerpt

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