Published in:
01-10-2020 | ASO Author Reflections
ASO Author Reflections: Does Site Matter? Impact of Tumor Location on Pathologic Characteristics, Recurrence, and Survival of Resected Pancreatic Ductal Adenocarcinoma
Authors:
Giuseppe Malleo, MD, PhD, Laura Maggino, MD, Carlos Fernàndez-del Castillo, MD, FACS, Roberto Salvia, MD, PhD
Published in:
Annals of Surgical Oncology
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Issue 10/2020
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Excerpt
With increasing knowledge of the mechanisms of carcinogenesis, many solid tumors are no longer considered a unique disease. For example, colorectal cancer exhibits differences in incidence, clinical presentation, and molecular features and outcomes, depending on tumor location. This has been attributed to the fact that, embryologically, the left and right side of the colon are distinct.
1 Although, in the pancreas, the dorsal and ventral buds do not differ embryologically, recent evidence suggests that body/tail pancreatic adenocarcinoma (PDAC) has peculiar clinical and molecular characteristics that may explain worse survival outcomes relative to head PDAC, as well as the later presentation in the disease process.
2 …
