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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 7/2019

01-07-2019 | Chronic Pancreatitis | Pancreatic Tumors

Exosomes from Pancreatic Juice: A Step Closer to the Holy Grail?

Author: Andrew M. Lowy, MD, FACS

Published in: Annals of Surgical Oncology | Issue 7/2019

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Excerpt

The readership of Annals of Surgical Oncology certainly needs no reminders about the inherently poor prognosis faced by pancreatic cancer patients. The past decade has witnessed an increasingly sophisticated understanding of the pancreatic ductal adenocarcinoma (PDAC) genetic and transcriptional landscape, an appreciation and characterization of the complexities of the tumor microenvironment and tumor metabolism, and the resultant identification of numerous novel therapeutic targets and new drugs. Despite this, the only improvements in patient outcomes have resulted from cytotoxic drug combinations. …
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Moffitt RA, Marayati R, Flate EL, et al. Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma. Nat Genet. 2015;47:1168–78.CrossRefPubMedPubMedCentral
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Balachandran VP, Łuksza M, Zhao JN, et al. Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer. Nature. 2017;551:512–516.CrossRefPubMedPubMedCentral
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Neoptolemos JP, Palmer DH, Ghaneh P, et al. European study group for pancreatic cancer. Comparison of adjuvant gemcitabine and capecitabine with gemcitabine monotherapy in patients with resected pancreatic cancer (ESPAC-4): a multicentre, open-label, randomised, phase 3 trial. Lancet. 2017;389:1011–1024.CrossRefPubMed
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Metadata
Title
Exosomes from Pancreatic Juice: A Step Closer to the Holy Grail?
Author
Andrew M. Lowy, MD, FACS
Publication date
01-07-2019
Publisher
Springer International Publishing
Published in
Annals of Surgical Oncology / Issue 7/2019
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-019-07271-5

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