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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 3/2018

01-12-2018 | ASO Author Reflections

ASO Author Reflections: Regulation of Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma by Vitamin D Supplementation

Authors: Yosuke Mukai, MD, Hidetoshi Eguchi, MD, PhD

Published in: Annals of Surgical Oncology | Special Issue 3/2018

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Excerpt

Pancreatic ductal adenocarcinoma (PDAC), in particular, is defined by a dense stromal compartment1 containing cancer-associated fibroblasts (CAFs) that express α-smooth muscle actin (SMA).2 In addition, CAFs are known to have a profound influence on tumor progression.3 Through the secretion of various cytokines, CAFs affect cancer growth, survival, metastasis, angiogenesis, and immunosurveillance.4 Therefore, targeting CAFs can improve therapeutic effects. To date, preoperative chemoradiation therapy (CRT) has been administered to PDAC patients. Some patients experience recurrence after curative surgery with preoperative CRT. A clinical question was raised as to whether chemoradiation therapies reduce (inactivate) or increase (activate) CAFs. However, the effect of current CRT on CAFs still is unclear. If current CRT activates CAFs, a therapy that inactivates CAFs needs to be administered with CRT. …
Literature
1.
Sherman MH, Yu RT, Engle DD, et al. Vitamin D receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy. Cell. 2014;159(1):80–93.CrossRefPubMedCentralPubMed
2.
Bachem MG, Schunemann M, Ramadani M, et al. Pancreatic carcinoma cells induce fibrosis by stimulating proliferation and matrix synthesis of stellate cells. Gastroenterology. 2005;128:907–21.CrossRefPubMed
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Pietras K, Ostman A. Hallmarks of cancer: interactions with the tumor stroma. Exp Cell Res. 2010;316:1324–31.CrossRefPubMed
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Pan B, Liao B, Niu Z, et al. Cancer-associated fibroblasts in pancreatic adenocarcinoma. Future Oncol. 2015;11:2603–10.CrossRefPubMed
5.
Mukai Y, Yamada D, Eguchi H, et al. Vitamin D supplementation is a promising therapy for pancreatic ductal adenocarcinoma in conjunction with current chemoradiation therapy. Ann Surg Oncol. 2018;25:1868–79.CrossRefPubMed
6.
Yamada D, Eguchi H, Iwagami Y, et al. Patients treated with preoperative chemoradiation for pancreatic ductal adenocarcinoma have impaired bone density, a predictor of distant metastasis. Ann Surg Oncol. 2017;24:3715–24.CrossRefPubMed
Metadata
Title
ASO Author Reflections: Regulation of Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma by Vitamin D Supplementation
Authors
Yosuke Mukai, MD
Hidetoshi Eguchi, MD, PhD
Publication date
01-12-2018
Publisher
Springer International Publishing
Published in
Annals of Surgical Oncology / Issue Special Issue 3/2018
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-018-6891-x

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