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Published in: Annals of Surgical Oncology 7/2018

01-07-2018 | Health Services Research and Global Oncology

Opioid Prescribing After Curative-Intent Surgery: A Qualitative Study Using the Theoretical Domains Framework

Authors: Jay S. Lee, MD, Vartika Parashar, Jacquelyn B. Miller, MA, Samantha M. Bremmer, Joceline V. Vu, MD, Jennifer F. Waljee, MD, MPH, MS, Lesly A. Dossett, MD, MPH

Published in: Annals of Surgical Oncology | Issue 7/2018

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Abstract

Background

Excessive opioid prescribing is common after curative-intent surgery, but little is known about what factors influence prescribing behaviors among surgeons. To identify targets for intervention, we performed a qualitative study of opioid prescribing after curative-intent surgery using the Theoretical Domains Framework, a well-established implementation science method for identifying factors influencing healthcare provider behavior.

Methods

Prior to data collection, we constructed a semi-structured interview guide to explore decision making for opioid prescribing. We then conducted interviews with surgical oncology providers at a single comprehensive cancer center. Interviews were recorded, transcribed verbatim, then independently coded by two investigators using the Theoretical Domains Framework to identify theoretical domains relevant to opioid prescribing. Relevant domains were then linked to behavior models to select targeted interventions likely to improve opioid prescribing.

Results

Twenty-one subjects were interviewed from November 2016 to May 2017, including attending surgeons, resident surgeons, physician assistants, and nurses. Five theoretical domains emerged as relevant to opioid prescribing: environmental context and resources; social influences; beliefs about consequences; social/professional role and identity; and goals. Using these domains, three interventions were identified as likely to change opioid prescribing behavior: (1) enablement (deploy nurses during preoperative visits to counsel patients on opioid use); (2) environmental restructuring (provide on-screen prompts with normative data on the quantity of opioid prescribed); and (3) education (provide prescribing guidelines).

Conclusions

Key determinants of opioid prescribing behavior after curative-intent surgery include environmental and social factors. Interventions targeting these factors are likely to improve opioid prescribing in surgical oncology.
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Literature
1.
go back to reference Rudd RA, Seth P, David F, Scholl L. Increases in drug and opioid-involved overdose deaths—United States, 2010–2015. MMWR. 2016;65(5051):1445–52.PubMed Rudd RA, Seth P, David F, Scholl L. Increases in drug and opioid-involved overdose deaths—United States, 2010–2015. MMWR. 2016;65(5051):1445–52.PubMed
2.
go back to reference Levy B, Paulozzi L, Mack KA, Jones CM. Trends in opioid analgesic-prescribing rates by specialty, U.S., 2007–2012. Am J Prev Med. 2015;49(3):409–13.CrossRefPubMedPubMedCentral Levy B, Paulozzi L, Mack KA, Jones CM. Trends in opioid analgesic-prescribing rates by specialty, U.S., 2007–2012. Am J Prev Med. 2015;49(3):409–13.CrossRefPubMedPubMedCentral
3.
go back to reference Brummett CM, Waljee JF, Goesling J, et al. New persistent opioid use after minor and major surgical procedures in US adults. JAMA Surg. 2017;152(6):e170504.CrossRefPubMed Brummett CM, Waljee JF, Goesling J, et al. New persistent opioid use after minor and major surgical procedures in US adults. JAMA Surg. 2017;152(6):e170504.CrossRefPubMed
4.
go back to reference Lee JS, Hu HM, Edelman AL, et al. New persistent opioid use among patients with cancer after curative-intent surgery. J Clin Oncol. 2017;35(36):4042–9.CrossRefPubMed Lee JS, Hu HM, Edelman AL, et al. New persistent opioid use among patients with cancer after curative-intent surgery. J Clin Oncol. 2017;35(36):4042–9.CrossRefPubMed
5.
go back to reference Jung BF, Herrmann D, Griggs J, Oaklander AL, Dworkin RH. Neuropathic pain associated with non-surgical treatment of breast cancer. Pain. 2005;118(1–2):10–4.CrossRefPubMed Jung BF, Herrmann D, Griggs J, Oaklander AL, Dworkin RH. Neuropathic pain associated with non-surgical treatment of breast cancer. Pain. 2005;118(1–2):10–4.CrossRefPubMed
6.
go back to reference Land SR, Kopec JA, Cecchini RS, et al. Neurotoxicity from oxaliplatin combined with weekly bolus fluorouracil and leucovorin as surgical adjuvant chemotherapy for stage II and III colon cancer: NSABP C-07. J Clin Oncol. 2007;25(16):2205–11.CrossRefPubMed Land SR, Kopec JA, Cecchini RS, et al. Neurotoxicity from oxaliplatin combined with weekly bolus fluorouracil and leucovorin as surgical adjuvant chemotherapy for stage II and III colon cancer: NSABP C-07. J Clin Oncol. 2007;25(16):2205–11.CrossRefPubMed
7.
go back to reference Mols F, Beijers T, Lemmens V, van den Hurk CJ, Vreugdenhil G, van de Poll-Franse LV. Chemotherapy-induced neuropathy and its association with quality of life among 2–11 year colorectal cancer survivors: results from the population-based PROFILES registry. J Clin Oncol. 2013;31(21):2699–707.CrossRefPubMed Mols F, Beijers T, Lemmens V, van den Hurk CJ, Vreugdenhil G, van de Poll-Franse LV. Chemotherapy-induced neuropathy and its association with quality of life among 2–11 year colorectal cancer survivors: results from the population-based PROFILES registry. J Clin Oncol. 2013;31(21):2699–707.CrossRefPubMed
9.
go back to reference Swarm RA, Abernethy AP, Anghelescu DL, et al. Adult cancer pain. J Natl Compr Cancer Netw. 2013;11(8):992–1022.CrossRef Swarm RA, Abernethy AP, Anghelescu DL, et al. Adult cancer pain. J Natl Compr Cancer Netw. 2013;11(8):992–1022.CrossRef
10.
go back to reference Fann JR, Ell K, Sharpe M. Integrating psychosocial care into cancer services. J Clin Oncol. 2012;30(11):1178–86.CrossRefPubMed Fann JR, Ell K, Sharpe M. Integrating psychosocial care into cancer services. J Clin Oncol. 2012;30(11):1178–86.CrossRefPubMed
11.
go back to reference Zabora J, BrintzenhofeSzoc K, Curbow B, Hooker C, Piantadosi S. The prevalence of psychological distress by cancer site. Psychooncology. 2001;10(1):19–28.CrossRefPubMed Zabora J, BrintzenhofeSzoc K, Curbow B, Hooker C, Piantadosi S. The prevalence of psychological distress by cancer site. Psychooncology. 2001;10(1):19–28.CrossRefPubMed
12.
go back to reference Brummett CM, Janda AM, Schueller CM, et al. Survey criteria for fibromyalgia independently predict increased postoperative opioid consumption after lower-extremity joint arthroplasty: a prospective, observational cohort study. Anesthesiology. 2013;119(6):1434–43.CrossRefPubMed Brummett CM, Janda AM, Schueller CM, et al. Survey criteria for fibromyalgia independently predict increased postoperative opioid consumption after lower-extremity joint arthroplasty: a prospective, observational cohort study. Anesthesiology. 2013;119(6):1434–43.CrossRefPubMed
13.
go back to reference Janda AM, As-Sanie S, Rajala B, et al. Fibromyalgia survey criteria are associated with increased postoperative opioid consumption in women undergoing hysterectomy. Anesthesiology. 2015;122(5):1103–11.CrossRefPubMed Janda AM, As-Sanie S, Rajala B, et al. Fibromyalgia survey criteria are associated with increased postoperative opioid consumption in women undergoing hysterectomy. Anesthesiology. 2015;122(5):1103–11.CrossRefPubMed
15.
go back to reference Hill MV, McMahon ML, Stucke RS, Barth RJ Jr. Wide variation and excessive dosage of opioid prescriptions for common general surgical procedures. Ann Surg. 2017;265(4):709–14.CrossRefPubMed Hill MV, McMahon ML, Stucke RS, Barth RJ Jr. Wide variation and excessive dosage of opioid prescriptions for common general surgical procedures. Ann Surg. 2017;265(4):709–14.CrossRefPubMed
16.
go back to reference Atkins L, Francis J, Islam R, et al. A guide to using the Theoretical Domains Framework of behaviour change to investigate implementation problems. Implement Sci. 2017;12(1):77.CrossRefPubMedPubMedCentral Atkins L, Francis J, Islam R, et al. A guide to using the Theoretical Domains Framework of behaviour change to investigate implementation problems. Implement Sci. 2017;12(1):77.CrossRefPubMedPubMedCentral
17.
go back to reference Cane J, O’Connor D, Michie S. Validation of the theoretical domains framework for use in behaviour change and implementation research. Implement Sci. 2012;7:37.CrossRefPubMedPubMedCentral Cane J, O’Connor D, Michie S. Validation of the theoretical domains framework for use in behaviour change and implementation research. Implement Sci. 2012;7:37.CrossRefPubMedPubMedCentral
18.
go back to reference Michie S, Johnston M, Abraham C, Lawton R, Parker D, Walker A. Making psychological theory useful for implementing evidence based practice: a consensus approach. Qual Saf Health Care. 2005;14(1):26.CrossRefPubMedPubMedCentral Michie S, Johnston M, Abraham C, Lawton R, Parker D, Walker A. Making psychological theory useful for implementing evidence based practice: a consensus approach. Qual Saf Health Care. 2005;14(1):26.CrossRefPubMedPubMedCentral
19.
go back to reference Islam R, Tinmouth AT, Francis JJ, et al. A cross-country comparison of intensive care physicians’ beliefs about their transfusion behaviour: a qualitative study using the Theoretical Domains Framework. Implement Sci. 2012;7:93.CrossRefPubMedPubMedCentral Islam R, Tinmouth AT, Francis JJ, et al. A cross-country comparison of intensive care physicians’ beliefs about their transfusion behaviour: a qualitative study using the Theoretical Domains Framework. Implement Sci. 2012;7:93.CrossRefPubMedPubMedCentral
20.
go back to reference Duncan EM, Francis JJ, Johnston M, et al. Learning curves, taking instructions, and patient safety: using a theoretical domains framework in an interview study to investigate prescribing errors among trainee doctors. Implement Sci. 2012;7(1):86.CrossRefPubMedPubMedCentral Duncan EM, Francis JJ, Johnston M, et al. Learning curves, taking instructions, and patient safety: using a theoretical domains framework in an interview study to investigate prescribing errors among trainee doctors. Implement Sci. 2012;7(1):86.CrossRefPubMedPubMedCentral
21.
go back to reference McSherry LA, Dombrowski SU, Francis JJ, et al. ‘It’s a can of worms’: understanding primary care practitioners’ behaviours in relation to HPV using the theoretical domains framework. Implement Sci. 2012;7(1):73.CrossRefPubMedPubMedCentral McSherry LA, Dombrowski SU, Francis JJ, et al. ‘It’s a can of worms’: understanding primary care practitioners’ behaviours in relation to HPV using the theoretical domains framework. Implement Sci. 2012;7(1):73.CrossRefPubMedPubMedCentral
22.
go back to reference Michie S, Pilling S, Garety P, et al. Difficulties implementing a mental health guideline: an exploratory investigation using psychological theory. Implement Sci. 2007;2:8.CrossRefPubMedPubMedCentral Michie S, Pilling S, Garety P, et al. Difficulties implementing a mental health guideline: an exploratory investigation using psychological theory. Implement Sci. 2007;2:8.CrossRefPubMedPubMedCentral
23.
go back to reference Patey AM, Islam R, Francis JJ, Bryson GL, Grimshaw JM. Anesthesiologists’ and surgeons’ perceptions about routine pre-operative testing in low-risk patients: application of the Theoretical Domains Framework (TDF) to identify factors that influence physicians’ decisions to order pre-operative tests. Implement Sci. 2012;7(1):52.CrossRefPubMedPubMedCentral Patey AM, Islam R, Francis JJ, Bryson GL, Grimshaw JM. Anesthesiologists’ and surgeons’ perceptions about routine pre-operative testing in low-risk patients: application of the Theoretical Domains Framework (TDF) to identify factors that influence physicians’ decisions to order pre-operative tests. Implement Sci. 2012;7(1):52.CrossRefPubMedPubMedCentral
24.
go back to reference Biezen R, Brijnath B, Grando D, Mazza D. Management of respiratory tract infections in young children: a qualitative study of primary care providers’ perspectives. NPJ Prim Care Respir Med. 2017;27:15.CrossRefPubMedPubMedCentral Biezen R, Brijnath B, Grando D, Mazza D. Management of respiratory tract infections in young children: a qualitative study of primary care providers’ perspectives. NPJ Prim Care Respir Med. 2017;27:15.CrossRefPubMedPubMedCentral
25.
go back to reference Walker AE, Grimshaw J, Johnston M, Pitts N, Steen N, Eccles M. PRIME—PRocess modelling in ImpleMEntation research: selecting a theoretical basis for interventions to change clinical practice. BMC Health Serv. Res. 2003;3(1):22.CrossRefPubMedPubMedCentral Walker AE, Grimshaw J, Johnston M, Pitts N, Steen N, Eccles M. PRIME—PRocess modelling in ImpleMEntation research: selecting a theoretical basis for interventions to change clinical practice. BMC Health Serv. Res. 2003;3(1):22.CrossRefPubMedPubMedCentral
26.
go back to reference Michie S, van Stralen MM, West R. The behaviour change wheel: a new method for characterising and designing behaviour change interventions. Implement Sci. 2011;6:42.CrossRefPubMedPubMedCentral Michie S, van Stralen MM, West R. The behaviour change wheel: a new method for characterising and designing behaviour change interventions. Implement Sci. 2011;6:42.CrossRefPubMedPubMedCentral
27.
go back to reference Soneji N, Clarke HA, Ko DT, Wijeysundera DN. Risks of developing persistent opioid use after major surgery. JAMA Surg. 2016;151(11):1083–4.CrossRefPubMed Soneji N, Clarke HA, Ko DT, Wijeysundera DN. Risks of developing persistent opioid use after major surgery. JAMA Surg. 2016;151(11):1083–4.CrossRefPubMed
28.
go back to reference Clarke H, Soneji N, Ko DT, Yun L, Wijeysundera DN. Rates and risk factors for prolonged opioid use after major surgery: population based cohort study. BMJ. 2014;348:g1251.CrossRefPubMedPubMedCentral Clarke H, Soneji N, Ko DT, Yun L, Wijeysundera DN. Rates and risk factors for prolonged opioid use after major surgery: population based cohort study. BMJ. 2014;348:g1251.CrossRefPubMedPubMedCentral
29.
go back to reference Alam A, Gomes T, Zheng H, Mamdani MM, Juurlink DN, Bell CM. Long-term analgesic use after low-risk surgery: a retrospective cohort study. Arch Intern Med. 2012;172(5):425–30.CrossRefPubMed Alam A, Gomes T, Zheng H, Mamdani MM, Juurlink DN, Bell CM. Long-term analgesic use after low-risk surgery: a retrospective cohort study. Arch Intern Med. 2012;172(5):425–30.CrossRefPubMed
30.
go back to reference Lee JS, Hu HM, Brummett CM, et al. Postoperative opioid prescribing and the pain scores on hospital consumer assessment of healthcare providers and systems survey. JAMA. 2017;317(19):2013–5.CrossRefPubMedPubMedCentral Lee JS, Hu HM, Brummett CM, et al. Postoperative opioid prescribing and the pain scores on hospital consumer assessment of healthcare providers and systems survey. JAMA. 2017;317(19):2013–5.CrossRefPubMedPubMedCentral
31.
go back to reference Bartels K, Mayes LM, Dingmann C, Bullard KJ, Hopfer CJ, Binswanger IA. Opioid use and storage patterns by patients after hospital discharge following surgery. PLoS ONE. 2016;11(1):e0147972.CrossRefPubMedPubMedCentral Bartels K, Mayes LM, Dingmann C, Bullard KJ, Hopfer CJ, Binswanger IA. Opioid use and storage patterns by patients after hospital discharge following surgery. PLoS ONE. 2016;11(1):e0147972.CrossRefPubMedPubMedCentral
32.
go back to reference Bates C, Laciak R, Southwick A, Bishoff J. Overprescription of postoperative narcotics: a look at postoperative pain medication delivery, consumption and disposal in urological practice. J Urol. 2011;185(2):551–5.CrossRefPubMed Bates C, Laciak R, Southwick A, Bishoff J. Overprescription of postoperative narcotics: a look at postoperative pain medication delivery, consumption and disposal in urological practice. J Urol. 2011;185(2):551–5.CrossRefPubMed
33.
go back to reference Bicket MC, Long JJ, Pronovost PJ, Alexander GC, Wu CL. Prescription opioid analgesics commonly unused after surgery: a systematic review. JAMA Surg. 2017;152(11):1066–71.CrossRefPubMed Bicket MC, Long JJ, Pronovost PJ, Alexander GC, Wu CL. Prescription opioid analgesics commonly unused after surgery: a systematic review. JAMA Surg. 2017;152(11):1066–71.CrossRefPubMed
34.
go back to reference Harris K, Curtis J, Larsen B, et al. Opioid pain medication use after dermatologic surgery a prospective observational study of 212 dermatologic surgery patients. JAMA Dermatol. 2013;149(3):317–21.CrossRefPubMed Harris K, Curtis J, Larsen B, et al. Opioid pain medication use after dermatologic surgery a prospective observational study of 212 dermatologic surgery patients. JAMA Dermatol. 2013;149(3):317–21.CrossRefPubMed
35.
go back to reference Maughan BC, Hersh EV, Shofer FS, et al. Unused opioid analgesics and drug disposal following outpatient dental surgery: a randomized controlled trial. Drug Alcohol Depend. 2016;168(1879-0046):328–34.CrossRefPubMed Maughan BC, Hersh EV, Shofer FS, et al. Unused opioid analgesics and drug disposal following outpatient dental surgery: a randomized controlled trial. Drug Alcohol Depend. 2016;168(1879-0046):328–34.CrossRefPubMed
36.
go back to reference Rodgers J, Cunningham K, Fitzgerald K, Finnerty E. Opioid consumption following outpatient upper extremity surgery. J Hand Surg Am. 2012;37(4):645–50.CrossRefPubMed Rodgers J, Cunningham K, Fitzgerald K, Finnerty E. Opioid consumption following outpatient upper extremity surgery. J Hand Surg Am. 2012;37(4):645–50.CrossRefPubMed
37.
go back to reference Steinmo SH, Michie S, Fuller C, Stanley S, Stapleton C, Stone SP. Bridging the gap between pragmatic intervention design and theory: using behavioural science tools to modify an existing quality improvement programme to implement “Sepsis Six”. Implement Sci. 2016;11(1):14.CrossRefPubMedPubMedCentral Steinmo SH, Michie S, Fuller C, Stanley S, Stapleton C, Stone SP. Bridging the gap between pragmatic intervention design and theory: using behavioural science tools to modify an existing quality improvement programme to implement “Sepsis Six”. Implement Sci. 2016;11(1):14.CrossRefPubMedPubMedCentral
38.
go back to reference Hill MV, Stucke RS, McMahon ML, Beeman JL, Barth RJ Jr. An Educational Intervention Decreases Opioid Prescribing After General Surgical Operations. Ann Surg. 2017; 267(3):468.CrossRef Hill MV, Stucke RS, McMahon ML, Beeman JL, Barth RJ Jr. An Educational Intervention Decreases Opioid Prescribing After General Surgical Operations. Ann Surg. 2017; 267(3):468.CrossRef
39.
go back to reference Howard RA, Waljee JF, Brummett CM, Englesbe MJ, Lee JS. Reduction in opioid prescribing through implementation of evidence-based prescribing guidelines. JAMA Surg. 2017. Howard RA, Waljee JF, Brummett CM, Englesbe MJ, Lee JS. Reduction in opioid prescribing through implementation of evidence-based prescribing guidelines. JAMA Surg. 2017.
40.
go back to reference Arabi YM, Al-Dorzi HM, Alamry A, et al. The impact of a multifaceted intervention including sepsis electronic alert system and sepsis response team on the outcomes of patients with sepsis and septic shock. Ann Intensiv Care. 2017;7(1):57.CrossRef Arabi YM, Al-Dorzi HM, Alamry A, et al. The impact of a multifaceted intervention including sepsis electronic alert system and sepsis response team on the outcomes of patients with sepsis and septic shock. Ann Intensiv Care. 2017;7(1):57.CrossRef
41.
go back to reference Steinmo S, Fuller C, Stone SP, Michie S. Characterising an implementation intervention in terms of behaviour change techniques and theory: the ‘Sepsis Six’ clinical care bundle. Implement Sci. 2015;10(1):111.CrossRefPubMedPubMedCentral Steinmo S, Fuller C, Stone SP, Michie S. Characterising an implementation intervention in terms of behaviour change techniques and theory: the ‘Sepsis Six’ clinical care bundle. Implement Sci. 2015;10(1):111.CrossRefPubMedPubMedCentral
42.
go back to reference Chiu AS, Healy JM, DeWane MP, Longo WE, Yoo PS. Trainees as agents of change in the opioid epidemic: optimizing the opioid prescription practices of surgical residents. J Surg Educ. 2018;75(1):65–71.CrossRefPubMed Chiu AS, Healy JM, DeWane MP, Longo WE, Yoo PS. Trainees as agents of change in the opioid epidemic: optimizing the opioid prescription practices of surgical residents. J Surg Educ. 2018;75(1):65–71.CrossRefPubMed
Metadata
Title
Opioid Prescribing After Curative-Intent Surgery: A Qualitative Study Using the Theoretical Domains Framework
Authors
Jay S. Lee, MD
Vartika Parashar
Jacquelyn B. Miller, MA
Samantha M. Bremmer
Joceline V. Vu, MD
Jennifer F. Waljee, MD, MPH, MS
Lesly A. Dossett, MD, MPH
Publication date
01-07-2018
Publisher
Springer International Publishing
Published in
Annals of Surgical Oncology / Issue 7/2018
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-018-6466-x

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