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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 7/2017

01-07-2017 | Hepatobiliary Tumors

Expansion of Criteria for Liver Transplantation in Hepatocellular Carcinoma: Better Patient Selection or a Slippery Slope?

Authors: Adam C. Yopp, MD, Jorge A. Marrero, MD, Amit G. Singal, MD

Published in: Annals of Surgical Oncology | Issue 7/2017

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Excerpt

Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths worldwide and one of the leading causes of death in patients with cirrhosis.1 In appropriately selected patients, orthotopic liver transplantation (OLT) provides 5-year overall survival rates approaching 70% and is the only therapy that offers both a cure for the cancer and the underlying liver cirrhosis. Prior to publication of the Milan criteria by Mazzaferro et al. in 1996, early results of OLT for HCC were dismal due to the high rate of recurrence and poor overall outcome. Adherence to the Milan criteria, a solitary tumor ≤5 cm or with three or less tumors each ≤3 cm with no evidence of vascular invasion or extrahepatic metastasis, has led to excellent post-transplant survival and forms the framework to award priority for deceased donor allocation in the US utilizing the model for end-stage liver disease (MELD) score.2 …
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Metadata
Title
Expansion of Criteria for Liver Transplantation in Hepatocellular Carcinoma: Better Patient Selection or a Slippery Slope?
Authors
Adam C. Yopp, MD
Jorge A. Marrero, MD
Amit G. Singal, MD
Publication date
01-07-2017
Publisher
Springer International Publishing
Published in
Annals of Surgical Oncology / Issue 7/2017
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-017-5802-x

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