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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 12/2016

Open Access 01-11-2016 | Breast Oncology

Society of Surgical Oncology–American Society for Radiation Oncology–American Society of Clinical Oncology Consensus Guideline on Margins for Breast-Conserving Surgery with Whole-Breast Irradiation in Ductal Carcinoma In Situ

Authors: Monica Morrow, MD, Kimberly J. Van Zee, MD, Lawrence J. Solin, MD, Nehmat Houssami, MBBS, PhD, Mariana Chavez-MacGregor, MD, Jay R. Harris, MD, Janet Horton, MD, Shelley Hwang, MD, Peggy L. Johnson, MD, M. Luke Marinovich, PhD, Stuart J. Schnitt, MD, Irene Wapnir, MD, Meena S. Moran, MD

Published in: Annals of Surgical Oncology | Issue 12/2016

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Abstract

Purpose

Controversy exists regarding the optimal negative margin width for ductal carcinoma in situ (DCIS) treated with breast-conserving surgery and whole-breast irradiation.

Methods

A multidisciplinary consensus panel used a meta-analysis of margin width and ipsilateral breast tumor recurrence (IBTR) from a systematic review of 20 studies including 7,883 patients and other published literature as the evidence base for consensus.

Results

Negative margins halve the risk of IBTR compared with positive margins defined as ink on DCIS. A 2-mm margin minimizes the risk of IBTR compared with smaller negative margins. More widely clear margins do not significantly decrease IBTR compared with 2-mm margins. Negative margins narrower than 2 mm alone are not an indication for mastectomy, and factors known to affect rates of IBTR should be considered in determining the need for re-excision.

Conclusion

Use of a 2-mm margin as the standard for an adequate margin in DCIS treated with whole-breast irradiation is associated with lower rates of IBTR and has the potential to decrease re-excision rates, improve cosmetic outcomes, and decrease health care costs. Clinical judgment should be used in determining the need for further surgery in patients with negative margins narrower than 2 mm.
Appendix
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Metadata
Title
Society of Surgical Oncology–American Society for Radiation Oncology–American Society of Clinical Oncology Consensus Guideline on Margins for Breast-Conserving Surgery with Whole-Breast Irradiation in Ductal Carcinoma In Situ
Authors
Monica Morrow, MD
Kimberly J. Van Zee, MD
Lawrence J. Solin, MD
Nehmat Houssami, MBBS, PhD
Mariana Chavez-MacGregor, MD
Jay R. Harris, MD
Janet Horton, MD
Shelley Hwang, MD
Peggy L. Johnson, MD
M. Luke Marinovich, PhD
Stuart J. Schnitt, MD
Irene Wapnir, MD
Meena S. Moran, MD
Publication date
01-11-2016
Publisher
Springer International Publishing
Published in
Annals of Surgical Oncology / Issue 12/2016
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-016-5449-z

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