Skip to main content
Top
Published in: Annals of Surgical Oncology 9/2015

01-09-2015 | Head and Neck Oncology

Plate Exposure After Anterolateral Thigh Free-Flap Reconstruction in Head and Neck Cancer Patients With Composite Mandibular Defects

Authors: Paolo Maria Fanzio, MD, Kai-Ping Chang, MD, PhD, Hsin-Hung Chen, MD, Hsiang-Hao Hsu, MD, Vijay Gorantla, MD, PhD, Mario G. Solari, MD, Huang-Kai Kao, MD

Published in: Annals of Surgical Oncology | Issue 9/2015

Login to get access

Abstract

Background

This study aimed to identify the risk factors for postoperative plate exposure in head and neck cancer patients with composite mandibular defects undergoing tumor ablation followed by bridging plate and anterolateral thigh (ALT) flap transfer.

Methods

Between January 2007 and June 2012, 1,452 patients who underwent free tissue transfer after head and neck cancer ablation were retrospectively reviewed. Only ALT flap coverage with a bridging plate for segmental mandibular defects was included. The Jewer’s classification was used to define the type of mandibular defect.

Results

The study enrolled 123 men and 7 women. The incidence of plate exposure was 37.7 % (49/130). The follow-up time ranged from 0.5 to 5.4 years (mean, 2.4 years). The 5-year probability of a plate exposure-free rate was 32.8 % for the patients with postoperative radiotherapy (RT) (n = 33) and 64.3 % for the patients without it (n = 97). Patients reconstructed with a fasciocutaneous or chimeric type of ALT flap had higher rates of plate exposure than those reconstructed with a musculocutaneous type of ALT flap (p = 0.002). As shown by logistic regression, the significant predictive risk factors for postoperative plate exposure still were postoperative RT [adjusted odds ratio (OR) 2.76, 95 % confidence interval (CI) 1.09–6.99, p = 0.031] and intraoperative blood loss (adjusted OR 2.37, 95 % CI 1.13–4.99, p = 0.022).

Conclusions

The type of ALT flap, postoperative RT, and intraoperative blood loss were the predisposing factors for increased risk of postoperative plate exposure in the specific disease group.
Appendix
Available only for authorised users
Literature
1.
go back to reference Head C. Microvascular flap reconstruction of the mandible: a comparison of bone grafts and bridging plates for restoration of mandibular continuity. Otolaryngol Head Neck Surg. 2003;129:48–54.PubMedCrossRef Head C. Microvascular flap reconstruction of the mandible: a comparison of bone grafts and bridging plates for restoration of mandibular continuity. Otolaryngol Head Neck Surg. 2003;129:48–54.PubMedCrossRef
2.
go back to reference Coletti DP, Ord R, Liu X. Mandibular reconstruction and second generation locking reconstruction plates: outcome of 110 patients. Int J Oral Maxillofac Surg. 2009;38:960–3.PubMedCrossRef Coletti DP, Ord R, Liu X. Mandibular reconstruction and second generation locking reconstruction plates: outcome of 110 patients. Int J Oral Maxillofac Surg. 2009;38:960–3.PubMedCrossRef
3.
go back to reference Pogrel MA, Podlesh S, Anthony JP, Alexander J. A comparison of vascularized and nonvascularized bone grafts for reconstruction of mandibular continuity defects. YJOMS. 1997;55:1200–6. Pogrel MA, Podlesh S, Anthony JP, Alexander J. A comparison of vascularized and nonvascularized bone grafts for reconstruction of mandibular continuity defects. YJOMS. 1997;55:1200–6.
4.
go back to reference Urken ML, Buchbinder D, Costantino PD, et al. Oromandibular reconstruction using microvascular composite flaps: report of 210 cases. Arch Otolaryngol Head Neck Surg. 1998;124:46–55.PubMedCrossRef Urken ML, Buchbinder D, Costantino PD, et al. Oromandibular reconstruction using microvascular composite flaps: report of 210 cases. Arch Otolaryngol Head Neck Surg. 1998;124:46–55.PubMedCrossRef
5.
go back to reference Chana JS, Chang Y-M, Wei F-C, et al. Segmental mandibulectomy and immediate free fibula osteoseptocutaneous flap reconstruction with endosteal implants: an ideal treatment method for mandibular ameloblastoma. Plast Reconstr Surg. 2004;113:80–7.PubMedCrossRef Chana JS, Chang Y-M, Wei F-C, et al. Segmental mandibulectomy and immediate free fibula osteoseptocutaneous flap reconstruction with endosteal implants: an ideal treatment method for mandibular ameloblastoma. Plast Reconstr Surg. 2004;113:80–7.PubMedCrossRef
6.
go back to reference Wei F-C, Celik N, Yang W-G, Chen I-H, Chang Y-M, Chen H-C. Complications after reconstruction by plate and soft-tissue free flap in composite mandibular defects and secondary salvage reconstruction with osteocutaneous flap. Plast Reconstr Surg. 2003;112:37–42.PubMedCrossRef Wei F-C, Celik N, Yang W-G, Chen I-H, Chang Y-M, Chen H-C. Complications after reconstruction by plate and soft-tissue free flap in composite mandibular defects and secondary salvage reconstruction with osteocutaneous flap. Plast Reconstr Surg. 2003;112:37–42.PubMedCrossRef
7.
go back to reference Heller KS, Dubner S, Keller A. Long-term evaluation of patients undergoing immediate mandibular reconstruction. Am J Surg. 1995;170:517–20.PubMedCrossRef Heller KS, Dubner S, Keller A. Long-term evaluation of patients undergoing immediate mandibular reconstruction. Am J Surg. 1995;170:517–20.PubMedCrossRef
8.
go back to reference Okura M, Isomura ET, Iida S, Kogo M. Long-term outcome and factors influencing bridging plates for mandibular reconstruction. Oral Oncol. 2005;41:791–8.PubMedCrossRef Okura M, Isomura ET, Iida S, Kogo M. Long-term outcome and factors influencing bridging plates for mandibular reconstruction. Oral Oncol. 2005;41:791–8.PubMedCrossRef
9.
go back to reference Ryu JK, Stern RL, Robinson MG, et al. Mandibular reconstruction using a titanium plate: the impact of radiation therapy on plate preservation. Int J Radiat Oncol Biol Phys. 1995;32:627–34.PubMedCrossRef Ryu JK, Stern RL, Robinson MG, et al. Mandibular reconstruction using a titanium plate: the impact of radiation therapy on plate preservation. Int J Radiat Oncol Biol Phys. 1995;32:627–34.PubMedCrossRef
10.
go back to reference Boyd JB, Mulholland RS, Davidson J, et al. The free flap and plate in oromandibular reconstruction: long-term review and indications. Plast Reconstr Surg. 1995;95:1018–28.PubMedCrossRef Boyd JB, Mulholland RS, Davidson J, et al. The free flap and plate in oromandibular reconstruction: long-term review and indications. Plast Reconstr Surg. 1995;95:1018–28.PubMedCrossRef
11.
go back to reference Yi Z, Jian-Guo Z, Guang-Yan Y, Ling L, Fu-Yun Z, Guo-Cheng Z. Reconstruction plates to bridge mandibular defects: a clinical and experimental investigation in biomechanical aspects. Int J Oral Maxillofac Surg. 1999;28:445–50.PubMedCrossRef Yi Z, Jian-Guo Z, Guang-Yan Y, Ling L, Fu-Yun Z, Guo-Cheng Z. Reconstruction plates to bridge mandibular defects: a clinical and experimental investigation in biomechanical aspects. Int J Oral Maxillofac Surg. 1999;28:445–50.PubMedCrossRef
12.
go back to reference Mariani P, Kowalski L, Magrin J. Reconstruction of large defects postmandibulectomy for oral cancer using plates and myocutaneous flaps: a long-term follow-up. Int J Oral Maxillofac Surg. 2006;35:427–32.PubMedCrossRef Mariani P, Kowalski L, Magrin J. Reconstruction of large defects postmandibulectomy for oral cancer using plates and myocutaneous flaps: a long-term follow-up. Int J Oral Maxillofac Surg. 2006;35:427–32.PubMedCrossRef
13.
go back to reference Poli T, Ferrari S, Bianchi B, Sesenna E. Primary oromandibular reconstruction using free flaps and thorp plates in cancer patients: a 5-year experience. Head Neck. 2002;25:15–23.CrossRef Poli T, Ferrari S, Bianchi B, Sesenna E. Primary oromandibular reconstruction using free flaps and thorp plates in cancer patients: a 5-year experience. Head Neck. 2002;25:15–23.CrossRef
14.
go back to reference Nicholson RE, Schuller DE, Forrest LA, Mountain RE, Ali T, Young D. Factors involved in long- and short-term mandibular plate exposure. Arch Otolaryngol Head Neck Surg. 1997;123:217–22.PubMedCrossRef Nicholson RE, Schuller DE, Forrest LA, Mountain RE, Ali T, Young D. Factors involved in long- and short-term mandibular plate exposure. Arch Otolaryngol Head Neck Surg. 1997;123:217–22.PubMedCrossRef
15.
go back to reference Boyd BJ, Gullane PJ, Rotstein LE, Brown DH, Irish JC. Classification of mandibular defects. Plast Reconstr Surg. 1993;92:1266–75.PubMed Boyd BJ, Gullane PJ, Rotstein LE, Brown DH, Irish JC. Classification of mandibular defects. Plast Reconstr Surg. 1993;92:1266–75.PubMed
16.
go back to reference Blackwell KE, Buchbinder D, Urken ML. Lateral mandibular reconstruction using soft tissue free flaps and plates. Arch Otolaryngol Head Neck Surg. 1996;122:672–8.PubMedCrossRef Blackwell KE, Buchbinder D, Urken ML. Lateral mandibular reconstruction using soft tissue free flaps and plates. Arch Otolaryngol Head Neck Surg. 1996;122:672–8.PubMedCrossRef
17.
go back to reference Arden RL, Rachel JD, Marks SC, Dang K. Volume-length impact of lateral jaw resections on complication rates. Arch Otolaryngol Head Neck Surg. 1999;125:68–72.PubMedCrossRef Arden RL, Rachel JD, Marks SC, Dang K. Volume-length impact of lateral jaw resections on complication rates. Arch Otolaryngol Head Neck Surg. 1999;125:68–72.PubMedCrossRef
18.
go back to reference Taniguchi Y, Okura M. Prognostic significance of perioperative blood transfusion in oral cavity squamous cell carcinoma. Head Neck. 2003;25:931–6.PubMedCrossRef Taniguchi Y, Okura M. Prognostic significance of perioperative blood transfusion in oral cavity squamous cell carcinoma. Head Neck. 2003;25:931–6.PubMedCrossRef
19.
go back to reference Huang W-C, Chen H-C, Jain V, et al. Reconstruction of through-and-through cheek defects involving the oral commissure, using chimeric flaps from the thigh lateral femoral circumflex system. Plast Reconstr Surg. 2002;109:433–41.PubMedCrossRef Huang W-C, Chen H-C, Jain V, et al. Reconstruction of through-and-through cheek defects involving the oral commissure, using chimeric flaps from the thigh lateral femoral circumflex system. Plast Reconstr Surg. 2002;109:433–41.PubMedCrossRef
20.
go back to reference Wei F-C, Jain V, Celik N, Chen H-C, Chuang DC-C, Lin C-H. Have we found an ideal soft tissue flap? An experience with 672 anterolateral thigh flaps. Plast Reconstr Surg. 2002;109:2219–26.PubMedCrossRef Wei F-C, Jain V, Celik N, Chen H-C, Chuang DC-C, Lin C-H. Have we found an ideal soft tissue flap? An experience with 672 anterolateral thigh flaps. Plast Reconstr Surg. 2002;109:2219–26.PubMedCrossRef
21.
go back to reference Chen H-C, Tang Y-B. Anterolateral thigh flap: an ideal soft tissue flap. Clin Plastic Surg. 2003:1–19. Chen H-C, Tang Y-B. Anterolateral thigh flap: an ideal soft tissue flap. Clin Plastic Surg. 2003:1–19.
22.
go back to reference Huang W-C, Wei F-C. Chimeric flap in clinical use. Clin Plastic Surg. 2003:1–11. Huang W-C, Wei F-C. Chimeric flap in clinical use. Clin Plastic Surg. 2003:1–11.
23.
go back to reference Kiyokawa K, Tai Y, Inoue Y, et al. Reliable, minimally invasive oromandibular reconstruction using metal plate rolled with pectoralis major myocutaneous flap. J Craniofac Surg. 2001;12:326–36.PubMedCrossRef Kiyokawa K, Tai Y, Inoue Y, et al. Reliable, minimally invasive oromandibular reconstruction using metal plate rolled with pectoralis major myocutaneous flap. J Craniofac Surg. 2001;12:326–36.PubMedCrossRef
24.
go back to reference Ettl T, Driemel O, Dresp BV, Reichert TE, Reuther J, Pistner H. Feasibility of alloplastic mandibular reconstruction in patients following removal of oral squamous cell carcinoma. J Craniomaxillofac Surg. 2010;38:350–4.PubMedCrossRef Ettl T, Driemel O, Dresp BV, Reichert TE, Reuther J, Pistner H. Feasibility of alloplastic mandibular reconstruction in patients following removal of oral squamous cell carcinoma. J Craniomaxillofac Surg. 2010;38:350–4.PubMedCrossRef
25.
go back to reference Spencer KR, Sizeland A, Taylor GI, Wiesenfeld D. The use of titanium mandibular reconstruction plates in patients with oral cancer. Int J Oral Maxillofac Surg. 1999;28:288–90.PubMedCrossRef Spencer KR, Sizeland A, Taylor GI, Wiesenfeld D. The use of titanium mandibular reconstruction plates in patients with oral cancer. Int J Oral Maxillofac Surg. 1999;28:288–90.PubMedCrossRef
26.
go back to reference Zwetyenga N, Pinsolle J, Siberchicot F, Majoufre-Lefebvre C. Reconstruction of lateral mandibular defects with dynamic bridging plates. Br J Oral Maxillofac Surg. 2002;40:307–12.PubMedCrossRef Zwetyenga N, Pinsolle J, Siberchicot F, Majoufre-Lefebvre C. Reconstruction of lateral mandibular defects with dynamic bridging plates. Br J Oral Maxillofac Surg. 2002;40:307–12.PubMedCrossRef
Metadata
Title
Plate Exposure After Anterolateral Thigh Free-Flap Reconstruction in Head and Neck Cancer Patients With Composite Mandibular Defects
Authors
Paolo Maria Fanzio, MD
Kai-Ping Chang, MD, PhD
Hsin-Hung Chen, MD
Hsiang-Hao Hsu, MD
Vijay Gorantla, MD, PhD
Mario G. Solari, MD
Huang-Kai Kao, MD
Publication date
01-09-2015
Publisher
Springer US
Published in
Annals of Surgical Oncology / Issue 9/2015
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-014-4322-1

Other articles of this Issue 9/2015

Annals of Surgical Oncology 9/2015 Go to the issue