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Published in: Annals of Surgical Oncology 7/2012

01-07-2012 | Gastrointestinal Oncology

Adenocarcinomas of the Esophagogastric Junction Are More Likely to Respond to Preoperative Chemotherapy than Distal Gastric Cancer

Authors: Daniel Reim, MD, Ralf Gertler, MD, Alexander Novotny, MD, Karen Becker, MD, Christian Meyer zum Büschenfelde, MD, Matthias Ebert, MD, Martin Dobritz, MD, Rupert Langer, MD, Heinz Hoefler, MD, Helmut Friess, MD, Christoph Schumacher

Published in: Annals of Surgical Oncology | Issue 7/2012

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Abstract

Background

Preoperative chemotherapy has been shown to improve outcome of patients with adenocarcinoma of the esophagogastric junction (AEG) and gastric cancer (GC), and histopathologic response has been identified as an independent prognostic parameter in these patients. A recent meta-analysis has identified patients with AEG as benefiting more from preoperative chemotherapy than patients with GC. The aim of this retrospective analysis was to prove these findings in an experienced single-center large patient cohort because there are currently no recruiting prospective clinical trials.

Methods

In a single center, 551 patients underwent preoperative platin-based chemotherapy followed by oncologic surgery for locally advanced AEG and GC. Pretherapeutic clinical parameters were correlated with histopathologic response to preoperative chemotherapy.

Results

Histopathologic response (<10% of residual tumor) was found in 130 patients (24%) and was significantly correlated with overall survival (P < 0.0001). Tumor localization at the esophagogastric junction (GE junction), lower baseline cT stage, and baseline cN0 stage were significantly associated with histopathologic response (P = 0.034, P = 0.015, and P = 0.002, respectively). In subgroup analyses, the latter two predictive parameters were confirmed only for AEG (n = 378) but not for other GC (n = 173). AEG patients who were pretherapeutically staged as having cT3/4, cN0 disease (n = 73) were identified as the subgroup with the highest rate of histopathologic response (48%).

Conclusions

AEG is more likely to respond to preoperative chemotherapy than GC, a finding that might help identify patients who would benefit from preoperative chemotherapy.
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Metadata
Title
Adenocarcinomas of the Esophagogastric Junction Are More Likely to Respond to Preoperative Chemotherapy than Distal Gastric Cancer
Authors
Daniel Reim, MD
Ralf Gertler, MD
Alexander Novotny, MD
Karen Becker, MD
Christian Meyer zum Büschenfelde, MD
Matthias Ebert, MD
Martin Dobritz, MD
Rupert Langer, MD
Heinz Hoefler, MD
Helmut Friess, MD
Christoph Schumacher
Publication date
01-07-2012
Publisher
Springer-Verlag
Published in
Annals of Surgical Oncology / Issue 7/2012
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-011-2147-8

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