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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 6/2010

01-06-2010 | Bone and Soft Tissue Sarcomas

Proton-Beam, Intensity-Modulated, and/or Intraoperative Electron Radiation Therapy Combined with Aggressive Anterior Surgical Resection for Retroperitoneal Sarcomas

Authors: Sam S. Yoon, MD, Yen-Lin Chen, MD, David G. Kirsch, MD, PhD, Ugwuji N. Maduekwe, MD, MMSc, Andrew E. Rosenberg, MD, G. Petur Nielsen, MD, Dushyant V. Sahani, MD, Edwin Choy, MD, David C. Harmon, MD, Thomas F. DeLaney, MD

Published in: Annals of Surgical Oncology | Issue 6/2010

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Abstract

Background

We sought to reduce local recurrence for retroperitoneal sarcomas by using a coordinated strategy of advanced radiation techniques and aggressive en-bloc surgical resection.

Methods

Proton-beam radiation therapy (PBRT) and/or intensity-modulated radiation therapy (IMRT) were delivered to improve tumor target coverage and spare selected adjacent organs. Surgical resection of tumor and adjacent organs was performed to obtain a disease-free anterior margin. Intraoperative electron radiation therapy (IOERT) was delivered to any close posterior margin.

Results

Twenty patients had primary tumors and eight had recurrent tumors. Tumors were large (median size 9.75 cm), primarily liposarcomas and leiomyosarcomas (71%), and were mostly of intermediate or high grade (81%). PBRT and/or IMRT were delivered to all patients, preferably preoperatively (75%), to a median dose of 50 Gy. Surgical resection included up to five adjacent organs, most commonly the colon (n = 7) and kidney (n = 7). Margins were positive for disease, usually posteriorly, in 15 patients (54%). IOERT was delivered to the posterior margin in 12 patients (43%) to a median dose of 11 Gy. Surgical complications occurred in eight patients (28.6%), and radiation-related complications occurred in four patients (14%). After a median follow-up of 33 months, only two patients (10%) with primary disease experienced local recurrence, while three patients (37.5%) with recurrent disease experienced local recurrence.

Conclusions

Aggressive resection of retroperitoneal sarcomas can achieve a disease-negative anterior margin. PBRT and/or IMRT with IOERT may possibly deliver sufficient radiation dose to the posterior margin to control microscopic residual disease. This strategy may minimize radiation-related morbidity and reduce local recurrence, especially in patients with primary disease.
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Metadata
Title
Proton-Beam, Intensity-Modulated, and/or Intraoperative Electron Radiation Therapy Combined with Aggressive Anterior Surgical Resection for Retroperitoneal Sarcomas
Authors
Sam S. Yoon, MD
Yen-Lin Chen, MD
David G. Kirsch, MD, PhD
Ugwuji N. Maduekwe, MD, MMSc
Andrew E. Rosenberg, MD
G. Petur Nielsen, MD
Dushyant V. Sahani, MD
Edwin Choy, MD
David C. Harmon, MD
Thomas F. DeLaney, MD
Publication date
01-06-2010
Publisher
Springer-Verlag
Published in
Annals of Surgical Oncology / Issue 6/2010
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-010-0935-1

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