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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 1/2010

01-01-2010 | Gastrointestinal Oncology

Influence of Laparoscopic Gastrectomy on the Detection Rate of Free Gastric Cancer Cells in the Peritoneal Cavity

Authors: Ying-Xue Hao, MD, Hua Zhong, MD, Pei-wu Yu, MD, Feng Qian, MD, Yong-liang Zhao, MD, Yan Shi, MD, Bo Tang, MD

Published in: Annals of Surgical Oncology | Issue 1/2010

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Abstract

Background

Whether laparoscopic gastrectomy affects the number of gastric cancer cells exfoliated from the cancer-invaded serosa remains unclear. This study aimed to compare the detection rate of free gastric cancer cells in the peritoneal cavity during laparoscopic and open gastrectomy.

Methods

Intraoperative peritoneal washings were collected from 83 gastric cancer patients undergoing laparoscopic gastrectomy and 81 patients undergoing open surgery. Hematoxylin and eosin (H&E) staining and real-time reverse-transcription polymerase chain reaction (RT-PCR) were used to examine the free cancer cells.

Results

The postoperative positive rates of free cancer cells detected by cytological and real-time RT-PCR were 39.76 and 43.20% in the laparoscopic and open groups, respectively. Depth of tumor invasion, area of invaded serosa, regional lymph node involvement, and higher pathological staging were significantly associated with presence of free cancer cells.

Conclusion

The laparoscopic techniques used in gastric cancer surgery did not increase the detection rate of free cancer cells in the peritoneal cavity compared with conventional techniques.
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Metadata
Title
Influence of Laparoscopic Gastrectomy on the Detection Rate of Free Gastric Cancer Cells in the Peritoneal Cavity
Authors
Ying-Xue Hao, MD
Hua Zhong, MD
Pei-wu Yu, MD
Feng Qian, MD
Yong-liang Zhao, MD
Yan Shi, MD
Bo Tang, MD
Publication date
01-01-2010
Publisher
Springer-Verlag
Published in
Annals of Surgical Oncology / Issue 1/2010
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-009-0703-2

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