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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 4/2008

01-04-2008 | Gastrointestinal Oncology

Distributions of Angiogenesis and Lymphangiogenesis in Gastrointestinal Intramucosal Tumors

Authors: Yan Gao, MD, MS, Wei-Xia Zhong, MD, Dian-Bin Mu, MD, Yin-Ping Yuan, MD, MS, Yu-Hua Zhang, MD, PhD, Jin-Ming Yu, MD, PhD, Lan-Ping Sun, Lei Wang, MD, PhD, Yu-Hui Li, MD, Jian-Bo Zhang, MD, Yan Zhao, Shu-Ping Cai, MD, Geng-Yin Zhou, MD, MS

Published in: Annals of Surgical Oncology | Issue 4/2008

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Abstract

Background

Although angiogenesis and lymphangiogenesis in gastrointestinal cancers has been investigated in many studies, their distribution characteristics in gastrointestinal intramucosal tumors have not been well addressed.

Methods

We evaluated the blood microvessel density (BMVD) and lymphatic microvessel density (LMVD) by immunostaining with monoclonal antibodies of CD34 and D2-40 in 37 patients with stomach intramucosal carcinoma and 28 patients with colorectal intramucosal neoplasia. Microvessels with endothelial cells labeled by CD34 but not by D2-40 were recognized as blood microvessels; and microvessels with endothelial cells labeled by both CD34 and D2-40 were recognized as lymphatic vessels. Furthermore, the relationships between expression of vascular endothelial growth factor (VEGF), VEGF-C, and BMVD, LMVD were investigated as well.

Results

The LMVD was significantly higher in peritumoral tissues than in corresponding normal tissues in gastrointestinal intramucosal tumors (20.87 versus 14.56, P = 0.003). However, there was no significant difference in the BMVD between peritumoral tissues and corresponding normal tissues (P = 0.166). The BMVD in peritumoral tissues was higher in patients with lymph node metastases than in patients without lymph nodes metastases (P = 0.047). Our results did not show significant association between VEGF, VEGF-C and BMVD, LMVD.

Conclusions

Our results suggested that the increase of lymphangiogenesis seems superior to the increase of angiogenesis in gastrointestinal intramucosal tumors.
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Metadata
Title
Distributions of Angiogenesis and Lymphangiogenesis in Gastrointestinal Intramucosal Tumors
Authors
Yan Gao, MD, MS
Wei-Xia Zhong, MD
Dian-Bin Mu, MD
Yin-Ping Yuan, MD, MS
Yu-Hua Zhang, MD, PhD
Jin-Ming Yu, MD, PhD
Lan-Ping Sun
Lei Wang, MD, PhD
Yu-Hui Li, MD
Jian-Bo Zhang, MD
Yan Zhao
Shu-Ping Cai, MD
Geng-Yin Zhou, MD, MS
Publication date
01-04-2008
Publisher
Springer-Verlag
Published in
Annals of Surgical Oncology / Issue 4/2008
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-007-9752-6

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