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Annals of Surgical Oncology

Published in:

01-01-2008 | Gastrointestinal Oncology

Radiofrequency Ablation for Metachronous Liver Metastasis from Colorectal Cancer after Curative Surgery

Authors: In Ja Park, MD, Hee Cheol Kim, MD, Chang Sik Yu, MD, Pyo Nyun Kim, MD, Hyung Jin Won, MD, Jin Cheon Kim, MD

Published in: Annals of Surgical Oncology | Issue 1/2008

Abstract

Background

We compared outcomes of surgery and radiofrequency thermal ablation (RFA) in patients with metachronous liver metastases.

Methods

Between October 1995 and December 2005, 59 patients underwent hepatic resection and 30 underwent RFA for metachronous liver metastases. Patients with extra-hepatic metastases, those who underwent both types of treatment, and those with synchronous hepatic metastasis were excluded.

Results

The two groups had similar mean age, sex ratio, comorbid medical conditions, primary disease stage, and frequency of solitary metastases. Preoperative mean serum carcinoembryonic antigen (CEA) level was significantly higher in the RFA group (13.4 ng/mL vs. 7.7 ng/mL; p = 0.02). Mean diameter of hepatic metastases was significantly greater in the resection than in the RFA group (3.1 cm vs. 2.0 cm; p = 0.001). Recurrence after treatment of metastasis was observed in 18 of 30 (60.0%) RFA and 33 of 59 (56%) resection patients. Local recurrence at the RFA site was observed in 7 of 30 (23%) patients. Time to recurrence (15 vs. 8 months, p = 0.02) and overall survival (56 vs. 36 months, p = 0.005) were significantly longer in the resection than in the RFA group. In the 69 patients with solitary metastases of diameter ≤3 cm, time to recurrence (p = 0.004) and overall survival were significantly greater in the resection group.

Conclusions

Compared with hepatic resection, RFA for metachronous hepatic metastases from colorectal cancer was associated with higher local recurrence and shorter recurrence-free and overall survival rates, even in patients with solitary, small (≤3 cm) lesions.

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Title: Radiofrequency Ablation for Metachronous Liver Metastasis from Colorectal Cancer after Curative Surgery
Authors: In Ja Park, MD
Hee Cheol Kim, MD
Chang Sik Yu, MD
Pyo Nyun Kim, MD
Hyung Jin Won, MD
Jin Cheon Kim, MD
Publication date: 01-01-2008
Publisher: Springer-Verlag
Published in: Annals of Surgical Oncology / Issue 1/2008
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI: https://doi.org/10.1245/s10434-007-9625-z

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Radiofrequency Ablation for Metachronous Liver Metastasis from Colorectal Cancer after Curative Surgery

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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