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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 11/2006

01-11-2006

Hepatic Resection for Colorectal Metastasis: Impact of Tumour Size

Authors: Zaed Z. R. Hamady, MRCS, Hassan Z. Malik, MD, FRCS, Robert Finch, FRACS, Robert Adair, MBChB, Ahmad Al-Mukhtar, FRCS, K. Rajendra Prasad, FRCS, Giles J. Toogood, DM, FRCS, J. Peter A. Lodge, MD, FRCS

Published in: Annals of Surgical Oncology | Issue 11/2006

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Abstract

Background

Many colorectal liver metastasis patients are denied surgical resection on the basis of tumour size. The aim of this study was to explore the impact of metastasis size on modern liver resection.

Methods

Using a prospectively collected database, this was a retrospective analysis of 484 consecutive patients who underwent liver resection for colorectal liver metastases between 1993 and 2003. The cohort was divided into two groups: smaller metastases (<8 cm) and larger metastases (≥ 8 cm). Those with larger metastases were then further stratified into big metastases (8–12 cm) and giant metastases (>12 cm). Demographic, pathological, surgical technique and outcome data were compared between the groups.

Results

There were 88 (18%) patients with metastases measuring 8 cm or larger. There was an association between higher carcinoembryonic antigen (CEA) and cancer antigen (CA) 19-9 levels and larger metastases. The actuarial 5-year survival for patients with larger metastases was 38% compared with 42% for smaller metastases (not statistically significant). Patients with giant metastases had poorer overall and disease-free survival (both nonsignificant) compared with those with big metastases: 29% and 28% at 5 years, respectively.

Conclusion

Patients with colorectal liver metastasis greater than 8 cm and up to 12 cm in size should not be treated differently from those with smaller lesions.
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Metadata
Title
Hepatic Resection for Colorectal Metastasis: Impact of Tumour Size
Authors
Zaed Z. R. Hamady, MRCS
Hassan Z. Malik, MD, FRCS
Robert Finch, FRACS
Robert Adair, MBChB
Ahmad Al-Mukhtar, FRCS
K. Rajendra Prasad, FRCS
Giles J. Toogood, DM, FRCS
J. Peter A. Lodge, MD, FRCS
Publication date
01-11-2006
Publisher
Springer-Verlag
Published in
Annals of Surgical Oncology / Issue 11/2006
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-006-9105-x

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