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01-12-2005

Malignant Vascular Tumors: Clinical Presentation, Surgical Therapy, and Long-Term Prognosis

Authors: Christine Leowardi, MD, Ulf Hinz, MSc, Yura Hormann, Moritz N. Wente, MD, Gunhild Mechtersheimer, MD, Frank Willeke, MD, Dittmar Böckler, MD, Helmut Friess, MD, Jens-Rainer Allenberg, MD, Christian Herfarth, MD, Markus W. Büchler, MD, Matthias H. M. Schwarzbach, MD

Published in: Annals of Surgical Oncology | Issue 12/2005

Abstract

Background

The aim of this study was to analyze the presentation of, surgery for, and prognosis of malignant vascular tumors (MVTs).

Methods

This was an observational single-center study. Patients who underwent operation for MVTs between 1988 and 2004 were included. Data were gathered prospectively in a computerized registry.

Results

Of 568 adult patients with soft tissue malignancies, 43 (7.6%) were treated for MVTs. Twenty-four men and 19 women (median age, 55.3 years) were referred for 30 primary tumors and 13 recurrences. Symptoms were observed in 90.7% of the cases (swelling [37.2%], pain [34.9%], extrusion [11.6%], hemorrhage [7%], weight loss [4.7%], loss of energy [4.7%], impaired function [4.7%], and others [30.2%]). Tumors were located in the extremities (n = 16), trunk (n = 3), abdomen (n = 15), retroperitoneum (n = 7), and thyroid gland (n = 2). Twenty-two (51.2%) angiosarcomas, nine (20.9%) malignant hemangiopericytomas, eight (18.6%) malignant epithelioid hemangioendotheliomas, and four (9.3%) lymphangiosarcomas were seen. The median overall survival after surgery was 21.4 months, with 2-, 5-, and 10-year overall survival rates of 41.5%, 38.3%, and 18.8%, respectively. MVTs of the extremities and trunk and localized disease indicated a better prognosis than abdominal or retroperitoneal MVTs (univariate and multivariate analyses: P = .0122 and P = .0287) and metastasized stages (univariate and multivariate analyses: P = .0187 and P = .0287).

Conclusions

A considerable number of patients with soft tissue malignancies undergo surgery for MVT. Various symptoms and a multilocular occurrence are typical. The course of MVTs is aggressive. Tumor site and stage are important prognostic factors. Surgery is potentially curative, especially for localized disease of the extremities and trunk.

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Title: Malignant Vascular Tumors: Clinical Presentation, Surgical Therapy, and Long-Term Prognosis
Authors: Christine Leowardi, MD
Ulf Hinz, MSc
Yura Hormann
Moritz N. Wente, MD
Gunhild Mechtersheimer, MD
Frank Willeke, MD
Dittmar Böckler, MD
Helmut Friess, MD
Jens-Rainer Allenberg, MD
Christian Herfarth, MD
Markus W. Büchler, MD
Matthias H. M. Schwarzbach, MD
Publication date: 01-12-2005
Publisher: Springer-Verlag
Published in: Annals of Surgical Oncology / Issue 12/2005
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI: https://doi.org/10.1245/ASO.2005.09.002

At a glance: The STEP trials

Springer Medicine

Malignant Vascular Tumors: Clinical Presentation, Surgical Therapy, and Long-Term Prognosis

Abstract

Background

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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