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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 12/2005

01-12-2005

Older Age Independently Predicts a Lower Risk of Sentinel Lymph Node Metastasis in Breast Cancer

Authors: Jason Caywood, BS, Richard J. Gray, MD, Joseph Hentz, MS, Barbara A. Pockaj, MD

Published in: Annals of Surgical Oncology | Issue 12/2005

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Abstract

Background

The influence of patient age on the risk of sentinel lymph node (SLN) metastasis in breast cancer has not been defined.

Methods

A breast cancer SLN database was analyzed. Factors associated with SLN metastasis were assessed by multiple logistic regression modeling. Age, T stage, estrogen receptor status, HER-2/neu status, grade, angiolymphatic invasion, lobular histology, tubular/mucinous histology, and the number of SLNs resected were assessed.

Results

Data were available for 810 patients with invasive breast cancer. SLN metastasis was observed in 22% of the patients. The factors most strongly associated with SLN metastasis were angiolymphatic invasion, T stage, and age. Age ranged from 29 to 95 years. The median age was 66 years. Overall, SLN metastasis was more common in younger patients (≤66 years) than in older patients (>66 years; P < .001). Among patients without angiolymphatic invasion, SLN metastasis was nearly twice as common in the younger patients as in the older patients. The effect of angiolymphatic invasion as a risk for SLN metastasis was much greater in the older age group.

Conclusions

In addition to known risk factors, age independently predicts the risk of SLN metastasis in breast cancer. Angiolymphatic invasion seems to be a more powerful predictor of SLN metastasis in older patients.
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Metadata
Title
Older Age Independently Predicts a Lower Risk of Sentinel Lymph Node Metastasis in Breast Cancer
Authors
Jason Caywood, BS
Richard J. Gray, MD
Joseph Hentz, MS
Barbara A. Pockaj, MD
Publication date
01-12-2005
Publisher
Springer-Verlag
Published in
Annals of Surgical Oncology / Issue 12/2005
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/ASO.2005.02.013

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