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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 6/2005

01-06-2005 | Editorial

A Motion for Cautious Optimism in the Treatment of Patients With Ocular Melanoma: The Ayes Have It

Author: H. Richard Alexander Jr., MD

Published in: Annals of Surgical Oncology | Issue 6/2005

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Excerpt

The article by Rivoire et al.1 in this issue of Annals of Surgical Oncology details the outcomes of 63 patients diagnosed with liver metastases from ocular melanoma from a cohort of 602 who were being evaluated by screening that consisted of serial physical examination, ultrasonography, and chest x-ray every 6 months after treatment of their primary neoplasm. Outcomes of the 63 individuals who developed liver metastases are detailed according to the nature of the treatment; 28 patients underwent surgical exploration with curative intent, yet only half (n = 14) were able to have complete surgical resection. The other 14 had incomplete resection with or without additional regional or systemic chemotherapy. The other 35, who had diffuse hepatic involvement on the basis of preoperative imaging, received systemic chemotherapy or best supportive care. I applaud the authors for such an informative study and find these data provocative in that they bring into focus many of the challenges and opportunities before us in combating this perfidious condition. …
Literature
1.
Rivoire M, Kodjikian L, Baldo S, Kaemmerlen P, Négrier S, Grange JD. Treatment of liver metastases from uveal melanoma. Ann Surg Oncol (in press)
2.
Diener-West, M, Reynolds, SM, Agugliaro, DJ,  et al. 2004Screening for metastasis from choroidal melanoma: the Collaborative Ocular Melanoma Study Group Report 23J Clin Oncol22243844
3.
Schmittel, A, Bechrakis, NE, Martus, P,  et al. 2004Independent prognostic factors for distant metastases and survival in patients with primary uveal melanomaEur J Cancer40238995CrossRefPubMed
4.
Isager, P, Ehlers, N, Overgaard, J 2004Prognostic factors for survival after enucleation for choroidal and ciliary body melanomasActa Ophthalmol Scand8251725CrossRefPubMed
5.
Feldman, ED, Pingpank, JF, Alexander, HR.,Jr 2004Regional treatment options for patients with ocular melanoma metastatic to the liverAnn Surg Oncol112907CrossRefPubMed
6.
Rose, DM, Essner, R, Hughes, TM,  et al. 2001Surgical resection for metastatic melanoma to the liver: the John Wayne Cancer Institute and Sydney Melanoma Unit experienceArch Surg1369505CrossRefPubMed
7.
Alexander, HR, Libutti, SK, Pingpank, JF,  et al. 2003Hyperthermic isolated hepatic perfusion (IHP) using melphalan for patients with ocular melanoma metastatic to liverClin Cancer Res963439
8.
Leyvraz, S, Spataro, V, Bauer, J,  et al. 1997Treatment of ocular melanoma metastatic to the liver by hepatic arterial chemotherapyJ Clin Oncol15258995PubMed
9.
Onken, MD, Worley, LA, Ehlers, JP, Harbour, JW 2004Gene expression profiling in uveal melanoma reveals two molecular classes and predicts metastatic deathCancer Res6472059PubMed
10.
Weinreich, DM, Elaraj, DM, Puhlmann, M,  et al. 2003Effect of interleukin 1 receptor antagonist gene transduction on human melanoma xenografts in nude miceCancer Res63595761PubMed
11.
Yang, H, Dithmar, S, Grossniklaus, HE 2004Interferon alpha 2b decreases hepatic micrometastasis in a murine model of ocular melanoma by activation of intrinsic hepatic natural killer cellsInvest Ophthalmol Vis Sci5205664CrossRef
12.
Yang, H, Akor, C, Dithmar, S, Grossniklaus, HE 2004Low dose adjuvant angiostatin decreases hepatic micrometastasis in murine ocular melanoma modelMol Vis1098795PubMed
Metadata
Title
A Motion for Cautious Optimism in the Treatment of Patients With Ocular Melanoma: The Ayes Have It
Author
H. Richard Alexander Jr., MD
Publication date
01-06-2005
Publisher
Springer-Verlag
Published in
Annals of Surgical Oncology / Issue 6/2005
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/ASO.2005.03.905

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