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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 13/2023

04-08-2023 | Radiotherapy | ASO Author Reflections

ASO Author Reflections: A More Effective Radiotherapy Modality for Early Breast Cancer: Intraoperative Radiotherapy as a Tumour Bed Boost Combined with Whole Breast Irradiation

Authors: Jiafa He, MM, Shengying Chen, MM, Rui Xu, MD

Published in: Annals of Surgical Oncology | Issue 13/2023

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Excerpt

In recent years, an increasing number of breast cancer centres have introduced intraoperative radiotherapy (IORT) into breast-conserving treatments. Because intraoperative radiotherapy has the advantages of shortening the treatment course, precisely locating the target area, and improving the radiobiological effect on the tumour, thus compensating for the shortcomings of conventional radiotherapy. However, there are limitations to IORT: for example, small area of irradiation, small total dose, short duration, and insufficient evidence. Although the ELIOT study and TARGIT-A study achieved equivocal and noninferiority results, respectively, the long-term, follow-up results continue to show that the local recurrence rate of single IORT is significantly higher than that of conventional radiotherapy.1‐4 Therefore, the effectiveness of IORT alone remains controversial. …
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Vaidya JS, Joseph DJ, Tobias JS, et al. Targeted intraoperative radiotherapy versus whole breast radiotherapy for breast cancer (TARGIT-A trial): an international, prospective, randomised, non-inferiority phase 3 trial. Lancet. 2010;376(9735):91–102.CrossRefPubMed
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Orecchia R, Veronesi U, Maisonneuve P, et al. Intraoperative irradiation for early breast cancer (ELIOT): long-term recurrence and survival outcomes from a single-centre, randomised, phase 3 equivalence trial. Lancet Oncol. 2021;22(5):597–608.CrossRefPubMed
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Metadata
Title
ASO Author Reflections: A More Effective Radiotherapy Modality for Early Breast Cancer: Intraoperative Radiotherapy as a Tumour Bed Boost Combined with Whole Breast Irradiation
Authors
Jiafa He, MM
Shengying Chen, MM
Rui Xu, MD
Publication date
04-08-2023
Publisher
Springer International Publishing
Published in
Annals of Surgical Oncology / Issue 13/2023
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-023-14057-3

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