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Open Access 25-06-2023 | NSCLC | ASO Author Reflections

ASO Author Reflections: Prognostic Impact of the Primary Tumor Resection for Lung Cancer Patients Diagnosed with Pleural Dissemination in the Perioperative Period—Importance of Biomarker-Based Treatment Decision Making

Authors: Kazuhiko Shien, MD, Toshiya Fujiwara, MD, Shinichi Toyooka, MD

Published in: Annals of Surgical Oncology | Issue 11/2023

Excerpt

Advances in imaging technology, including PET/CT, have improved the accuracy of preoperative staging of non-small-cell lung cancer (NSCLC).¹ Pleural dissemination (PD) or malignant pleural effusion (MPE) was found during surgery or on postoperative pathology in some patients, although it was not noted on preoperative imaging studies.² According to the eighth edition of the TNM staging system, NSCLC with PD or MPE is classified as stage IVA, and surgical resection is generally not indicated.³ Occasionally, primary tumor resection is performed in these patients for histological examination, genetic testing, and symptom relief. Interestingly, some patients with radiologically undetermined PD and/or MPE demonstrated long-term survival, but the prognostic factors remain unknown. …

Gridelli C, Rossi A, Carbone DP, et al. Non-small-cell lung cancer. Nat Rev Dis Primers. 2015;1:15009.CrossRefPubMed

Iida T, Shiba M, Yoshino I, et al. Surgical intervention for non-small-cell lung cancer patients with pleural carcinomatosis: results from the japanese lung cancer registry in 2004. J Thorac Oncol. 2015;10:1076–82.CrossRefPubMed

Goldstraw P, Chansky K, Crowley J, et al. The IASLC lung cancer staging project: proposals for revision of the TNM stage groupings in the forthcoming (eighth) edition of the TNM classification for lung cancer. J Thorac Oncol. 2016;11(1):39–51.CrossRefPubMed

Fujiwara T, Shien K, Matsuura M, et al. EGFR mutation is a prognostic factor in lung cancer patients with pleural dissemination detected during or after surgery. Ann Surg Oncol. 2023. https://doi.org/10.1245/s10434-023-13791-y.CrossRefPubMed

Title: ASO Author Reflections: Prognostic Impact of the Primary Tumor Resection for Lung Cancer Patients Diagnosed with Pleural Dissemination in the Perioperative Period—Importance of Biomarker-Based Treatment Decision Making
Authors: Kazuhiko Shien, MD
Toshiya Fujiwara, MD
Shinichi Toyooka, MD
Publication date: 25-06-2023
Publisher: Springer International Publishing
Keywords: NSCLC
NSCLC
Lung Cancer
Lung Cancer
Lung Cancer
Thoracotomy
Biomarkers
Published in: Annals of Surgical Oncology / Issue 11/2023
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI: https://doi.org/10.1245/s10434-023-13808-6

Keynote webinar | Spotlight on medication adherence

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ASO Author Reflections: Prognostic Impact of the Primary Tumor Resection for Lung Cancer Patients Diagnosed with Pleural Dissemination in the Perioperative Period—Importance of Biomarker-Based Treatment Decision Making

Excerpt

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Excerpt

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