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01-02-2016 | Gastrointestinal Oncology

Predictive Potential of Preoperative Nutritional Status in Long-Term Outcome Projections for Patients with Gastric Cancer

Authors: Katsunobu Sakurai, MD, PhD, Masaichi Ohira, MD, PhD, Tatsuro Tamura, MD, Takahiro Toyokawa, MD, PhD, Ryosuke Amano, MD, PhD, Naoshi Kubo, MD, PhD, Hiroaki Tanaka, MD, PhD, Kazuya Muguruma, MD, PhD, Masakazu Yashiro, MD, PhD, Kiyoshi Maeda, MD, PhD, Kosei Hirakawa, MD, PhD

Published in: Annals of Surgical Oncology | Issue 2/2016

Abstract

Background

Preoperative nutritional status not only correlates with the incidence of postoperative complications but also may be indicative of long-term outcomes for patients with cancer. The impact of preoperative nutritional status on outcomes for patients undergoing gastrectomy for gastric cancer (GC) was investigated.

Methods

The study reviewed 594 patients treated for GC by gastrectomy at the authors’ hospital between January, 2004 and December, 2010. Onodera’s prognostic nutritional index (PNI) was invoked, using an optimal cut point to group patients as having high (PNI > 45; n = 449) or low (PNI ≤ 45; n = 145) nutritional status. Clinicopathologic features, perioperative results, and long-term outcomes, including cause of death, were compared.

Results

Multivariate analysis of 5-year overall survival (OS) and disease-specific survival (DSS) indicated that low PNI was independently associated with unfavorable outcomes for patients with GC. In subgroup analysis, the 5-year OS and DSS rates for patients with GC at stages 1 and 2 were significantly worse in the low PNI group than in the high PNI group. Although wound and extrasurgical field infections also tended to be more frequent in the low PNI group, postoperative intraabdominal infections did not differ significantly by group.

Conclusions

Preoperative PNI may have merit as a gauge of prognosis for patients with GC at stages 1 and 2, but PNI and postoperative morbidity showed no correlation in this setting.

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Title: Predictive Potential of Preoperative Nutritional Status in Long-Term Outcome Projections for Patients with Gastric Cancer
Authors: Katsunobu Sakurai, MD, PhD
Masaichi Ohira, MD, PhD
Tatsuro Tamura, MD
Takahiro Toyokawa, MD, PhD
Ryosuke Amano, MD, PhD
Naoshi Kubo, MD, PhD
Hiroaki Tanaka, MD, PhD
Kazuya Muguruma, MD, PhD
Masakazu Yashiro, MD, PhD
Kiyoshi Maeda, MD, PhD
Kosei Hirakawa, MD, PhD
Publication date: 01-02-2016
Publisher: Springer US
Published in: Annals of Surgical Oncology / Issue 2/2016
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI: https://doi.org/10.1245/s10434-015-4814-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Predictive Potential of Preoperative Nutritional Status in Long-Term Outcome Projections for Patients with Gastric Cancer

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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