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01-03-2012 | Pancreatic Tumors

Postoperative Complications Deteriorate Long-Term Outcome in Pancreatic Cancer Patients

Authors: Carsten Kamphues, MD, Roberta Bova, MD, Dorothee Schricke, Michael Hippler-Benscheidt, Frederick Klauschen, MD, Albrecht Stenzinger, MD, Daniel Seehofer, MD, Matthias Glanemann, MD, Peter Neuhaus, MD, Marcus Bahra, MD

Published in: Annals of Surgical Oncology | Issue 3/2012

Abstract

Background

Different tumor-specific prognostic factors have been identified in recent years for patients who undergo surgery due to pancreatic head cancer, but the results often were inconsistent. Furthermore, the impact of postoperative complications on patient long-term survival has not been described.

Methods

The long-term outcome of 428 patients who underwent resection of pancreatic head cancer at our center during a 17-year period was evaluated. Perioperative details, including postoperative complications, as well as the follow-up of all patients who left the hospital postoperatively were collected in a prospective database. Univariate and multivariate models were used to identify potential prognostic factors and to evaluate the impact of postoperative complications on long-term survival.

Results

The median survival was 15.5 months with a postoperative complication rate (grade I–IV) of 32.7%. Independent prognostic significance was detected for grading (P < 0.001), R status (P = 0.001), and lymph node status (P = 0.003). The occurrence of severe postoperative complications (grade III–IV) was associated with a significantly shortened survival (16.5 vs. 12.4 months; P = 0.002) and was identified as an independent prognostic factor (P = 0.002).

Conclusions

This large study demonstrates that severe postoperative complications have a strong impact on the long-term survival of patients with pancreatic head cancer comparable to tumor characteristics, such as lymph node status, grading, or R status. As a result, the improvement of surgical procedures in specialized centers might lead to a survival benefit in these patients.

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Title: Postoperative Complications Deteriorate Long-Term Outcome in Pancreatic Cancer Patients
Authors: Carsten Kamphues, MD
Roberta Bova, MD
Dorothee Schricke
Michael Hippler-Benscheidt
Frederick Klauschen, MD
Albrecht Stenzinger, MD
Daniel Seehofer, MD
Matthias Glanemann, MD
Peter Neuhaus, MD
Marcus Bahra, MD
Publication date: 01-03-2012
Publisher: Springer-Verlag
Published in: Annals of Surgical Oncology / Issue 3/2012
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI: https://doi.org/10.1245/s10434-011-2041-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Postoperative Complications Deteriorate Long-Term Outcome in Pancreatic Cancer Patients

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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