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Clinical Phytoscience
Published in: Clinical Phytoscience 1/2018

Open Access 01-12-2018 | Original contribution

A dose Dependent hepatoprotective and nephroprotective activity of eucalyptus oil on Streptozotocin induced diabetic mice model

Authors: Monalisa Chakraborty, Biswajoy Bagchi, Sukhen Das, Ruma Basu, Papiya Nandy

Published in: Clinical Phytoscience | Issue 1/2018

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Abstract

Background

Eucalyptus globulus are a prime source of global eucalyptus oil production. This oil has therapeutic, flavoring, antimicrobial, and biopesticide properties. This oil has got popularity because they are reported as pharmacologically active.
A study has been conducted with the aim to find dose dependant effect of eucalyptus oil on diabetic mice induced with Streptozotocin (STZ) and analyze the hepatoprotective and nephroprotective nature through biochemical and histological study.
STZ at low dose was used to damage pancreatic β cells and induce type II diabetes on mice model. Oil was used in different percentages namely, 0.5%, 1%, 1.5%, 2% for treating hyperglycemia. Then after a treatment of 28 days, the total body weight, and biochemical parameters including blood glucose, serum glutamic pyruvic transaminase (SGPT), serum glutamic oxaloacetic transaminase (SGOT), alkaline phosphatase (ALP), gamma-glutamyl transpeptidase (GGT), Bilirubin, cholesterol, urea, creatinine were checked thoroughly. A complete histological study of different organs like liver, kidney, and pancreas was done.

Results

From the explained experiment the result was quite interesting which showed among all the concentration of essential oil, 1.5% showed maximum effect on hyperglycemia with a rapid approach to normalize high blood glucose level and also other biochemical parameters. The tissue was got rejuvenated and behaved as normal cells after being treated with 1.5% oil.

Conclusion

So the main purpose of the work is to search for an alternative substituent of antidiabetic drug which can work as potentially as conventional drug for diabetes but without having side effects. And Eucalyptus oil proved to be safe and steady source for hyperglycemic patients at a particular dose. So it can be used for further diabetic research.
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Metadata
Title
A dose Dependent hepatoprotective and nephroprotective activity of eucalyptus oil on Streptozotocin induced diabetic mice model
Authors
Monalisa Chakraborty
Biswajoy Bagchi
Sukhen Das
Ruma Basu
Papiya Nandy
Publication date
01-12-2018
Publisher
Springer Berlin Heidelberg
Published in
Clinical Phytoscience / Issue 1/2018
Electronic ISSN: 2199-1197
DOI
https://doi.org/10.1186/s40816-018-0067-x

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