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Clinical Phytoscience
Published in: Clinical Phytoscience 1/2018

Open Access 01-12-2018 | Original contribution

Evaluation of the efficacy of Acalypha wilkesiana leaves in managing cardiovascular disease risk factors in rabbits exposed to salt-loaded diets

Authors: Kingsley Omage, Marshall A. Azeke, Sylvia O. Omage

Published in: Clinical Phytoscience | Issue 1/2018

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Abstract

Background

This study was conducted to evaluate the therapeutic benefits of oral administration of extracts of Acalypha wilkesiana leaves on some serum parameters that are indicators or risk factors of cardiovascular diseases, in salt loaded rabbits.

Method

Thirty experimental rabbits used for this study were randomized into five groups (A to E) of six rabbits. Rabbits in groups A to D were given salt loaded diets. Groups B and C animals were also treated with aqueous and ethanol extracts of Acalypha wilkesiana leaves respectively while rabbits in group E served as control.

Results

Salt loading resulted in a significantly (P < 0.05) higher serum albumin, cholesterol, LDL-cholesterol and lower serum globulin, HDL-cholesterol, triglycerides, as compared with the control. Treatment with Acalypha wilkesiana leaf extracts (aqueous or ethanol), at a dose of 300 mg/kg body weight, resulted in a significantly (P < 0.05) higher serum triglycerides, HDL-cholesterol, globulin, and lower serum total protein, albumin, LDL-cholesterol, cholesterol, as compared with the control, in the salt loaded rabbits.

Conclusion

Acalypha wilkesiana may be useful in the management of risk factors of cardiovascular diseases.
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Metadata
Title
Evaluation of the efficacy of Acalypha wilkesiana leaves in managing cardiovascular disease risk factors in rabbits exposed to salt-loaded diets
Authors
Kingsley Omage
Marshall A. Azeke
Sylvia O. Omage
Publication date
01-12-2018
Publisher
Springer Berlin Heidelberg
Published in
Clinical Phytoscience / Issue 1/2018
Electronic ISSN: 2199-1197
DOI
https://doi.org/10.1186/s40816-018-0060-4

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