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Open Access 01-12-2018 | Mini review

The role of S100 proteins in the pathogenesis and monitoring of autoinflammatory diseases

Authors: Dirk Holzinger, Dirk Foell, Christoph Kessel

Published in: Molecular and Cellular Pediatrics | Issue 1/2018

Abstract

S100A8/A9 and S100A12 are released from activated monocytes and granulocytes and act as proinflammatory endogenous toll-like receptor (TLR)4-ligands. S100 serum concentrations correlate with disease activity, both during local and systemic inflammatory processes. In some autoinflammatory diseases such as familial Mediterranean fever (FMF) or systemic juvenile idiopathic arthritis (SJIA), dysregulation of S100 release may be involved in the pathogenesis. Moreover, S100 serum levels are a valuable supportive tool in the diagnosis of SJIA in fever of unknown origin. Furthermore, S100 levels can be used to monitor disease activity to subclinical level, as their serum concentrations decrease with successful treatment.

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Title: The role of S100 proteins in the pathogenesis and monitoring of autoinflammatory diseases
Authors: Dirk Holzinger
Dirk Foell
Christoph Kessel
Publication date: 01-12-2018
Publisher: Springer Berlin Heidelberg
Published in: Molecular and Cellular Pediatrics / Issue 1/2018
Electronic ISSN: 2194-7791
DOI: https://doi.org/10.1186/s40348-018-0085-2

At a glance: The STEP trials

Springer Medicine

The role of S100 proteins in the pathogenesis and monitoring of autoinflammatory diseases

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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