Skip to main content
Top
Published in: Molecular and Cellular Pediatrics 1/2014

Open Access 01-12-2014 | Mini review

Fanconi anemia: young patients at high risk for squamous cell carcinoma

Authors: Eunike Velleuer, Ralf Dietrich

Published in: Molecular and Cellular Pediatrics | Issue 1/2014

Login to get access

Abstract

Background

Fanconi anemia is one of the best studied inherited cancer-prone diseases. Greatly improved protocols for hematopoietic stem cell transplantation increasingly save the lives of these young patients. However, in both transplanted and not transplanted patients, the emergence of aggressive squamous cell carcinoma represents a major medical challenge.

Conclusions

This mini review summarizes current knowledge about the pathogenesis of squamous cell carcinoma (SCC) in the special context of Fanconi anemia.
Appendix
Available only for authorised users
Literature
1.
go back to reference Alter BP, Joenje H, Oostra AB, Pals G: Fanconi anemia: adult head and neck cancer and hematopoietic mosaicism. Arch Otolaryngol Head Neck Surg 2005, 131(7):635–639. 10.1001/archotol.131.7.635CrossRef Alter BP, Joenje H, Oostra AB, Pals G: Fanconi anemia: adult head and neck cancer and hematopoietic mosaicism. Arch Otolaryngol Head Neck Surg 2005, 131(7):635–639. 10.1001/archotol.131.7.635CrossRef
2.
go back to reference Alter BP: Cancer in Fanconi anemia, 1927–2001. Cancer 2003, 97(2):425–440. 10.1002/cncr.11046CrossRef Alter BP: Cancer in Fanconi anemia, 1927–2001. Cancer 2003, 97(2):425–440. 10.1002/cncr.11046CrossRef
3.
go back to reference Alter BP: Fanconi's anemia, transplantation, and cancer. Pediatr Transplant 2005, 9(Suppl 7):81–86. 10.1111/j.1399-3046.2005.00440.xCrossRef Alter BP: Fanconi's anemia, transplantation, and cancer. Pediatr Transplant 2005, 9(Suppl 7):81–86. 10.1111/j.1399-3046.2005.00440.xCrossRef
4.
go back to reference Kutler DI, Auerbach AD, Satagopan J, Giampietro PF, Batish SD, Huvos AG, Goberdhan A, Shah JP, Singh B: High incidence of head and neck squamous cell carcinoma in patients with Fanconi anemia. Arch Otolaryngol Head Neck Surg 2003, 129(1):106–112. 10.1001/archotol.129.1.106CrossRef Kutler DI, Auerbach AD, Satagopan J, Giampietro PF, Batish SD, Huvos AG, Goberdhan A, Shah JP, Singh B: High incidence of head and neck squamous cell carcinoma in patients with Fanconi anemia. Arch Otolaryngol Head Neck Surg 2003, 129(1):106–112. 10.1001/archotol.129.1.106CrossRef
5.
go back to reference Rosenberg PS, Socié G, Alter BP, Gluckman E: Risk of head and neck squamous cell cancer and death in patients with Fanconi anemia who did and did not receive transplants. Blood 2005, 105(1):67–73. 10.1182/blood-2004-04-1652CrossRef Rosenberg PS, Socié G, Alter BP, Gluckman E: Risk of head and neck squamous cell cancer and death in patients with Fanconi anemia who did and did not receive transplants. Blood 2005, 105(1):67–73. 10.1182/blood-2004-04-1652CrossRef
6.
go back to reference Masserot C, Peffault de Latour R, Rocha V, Leblanc T, Rigolet A, Pascal F, Janin A, Soulier J, Gluckman E, Socié G: Head and neck squamous cell carcinoma in 13 patients with Fanconi anemia after hematopoietic stem cell transplantation. Cancer 2008, 113(12):3315–3322. 10.1002/cncr.23954CrossRef Masserot C, Peffault de Latour R, Rocha V, Leblanc T, Rigolet A, Pascal F, Janin A, Soulier J, Gluckman E, Socié G: Head and neck squamous cell carcinoma in 13 patients with Fanconi anemia after hematopoietic stem cell transplantation. Cancer 2008, 113(12):3315–3322. 10.1002/cncr.23954CrossRef
7.
go back to reference Kalb R, Duerr M, Wagner M, Herterich S, Gross M, Digweed M, Joenje H, Hoehn H, Schindler D: Lack of sensitivity of primary Fanconi's anemia fibroblasts to UV and ionizing radiation. Radiat Res 2004, 161(3):318–325. 10.1667/RR3138CrossRef Kalb R, Duerr M, Wagner M, Herterich S, Gross M, Digweed M, Joenje H, Hoehn H, Schindler D: Lack of sensitivity of primary Fanconi's anemia fibroblasts to UV and ionizing radiation. Radiat Res 2004, 161(3):318–325. 10.1667/RR3138CrossRef
8.
go back to reference Wong WM, Parvathaneni U, Jewell PD, Martins RG, Futran ND, Laramore GE, Liao JJ: Squamous cell carcinoma of the oral tongue in a patient with Fanconi anemia treated with radiotherapy and concurrent cetuximab: a case report and review of the literature. Head Neck 2013, 35(10):E292-E298. Wong WM, Parvathaneni U, Jewell PD, Martins RG, Futran ND, Laramore GE, Liao JJ: Squamous cell carcinoma of the oral tongue in a patient with Fanconi anemia treated with radiotherapy and concurrent cetuximab: a case report and review of the literature. Head Neck 2013, 35(10):E292-E298.
9.
go back to reference Joenje H, Arwert F, Eriksson AW, de Koning H, Oostra AB: Oxygen-dependence of chromosomal aberrations in Fanconi's anaemia. Nature 1981, 290(5802):142–143. 10.1038/290142a0CrossRef Joenje H, Arwert F, Eriksson AW, de Koning H, Oostra AB: Oxygen-dependence of chromosomal aberrations in Fanconi's anaemia. Nature 1981, 290(5802):142–143. 10.1038/290142a0CrossRef
10.
go back to reference Pagano G, Talamanca AA, Castello G, d'Ischia M, Pallardó FV, Petrović S, Porto B, Tiano L, Zatterale A: From clinical description, to in vitro and animal studies, and backward to patients: oxidative stress and mitochondrial dysfunction in Fanconi anemia. Free Radic Biol Med 2013, 58: 118–125. 10.1016/j.freeradbiomed.2013.01.015CrossRef Pagano G, Talamanca AA, Castello G, d'Ischia M, Pallardó FV, Petrović S, Porto B, Tiano L, Zatterale A: From clinical description, to in vitro and animal studies, and backward to patients: oxidative stress and mitochondrial dysfunction in Fanconi anemia. Free Radic Biol Med 2013, 58: 118–125. 10.1016/j.freeradbiomed.2013.01.015CrossRef
11.
go back to reference Romick-Rosendale LE, Lui VW, Grandis JR, Wells SI: The Fanconi anemia pathway: repairing the link between DNA damage and squamous cell carcinoma. Mutat Res 2013, 743–744: 78–88. 10.1016/j.mrfmmm.2013.01.001CrossRef Romick-Rosendale LE, Lui VW, Grandis JR, Wells SI: The Fanconi anemia pathway: repairing the link between DNA damage and squamous cell carcinoma. Mutat Res 2013, 743–744: 78–88. 10.1016/j.mrfmmm.2013.01.001CrossRef
12.
go back to reference Ameziane N, Chen F, Leemans CR, Brakenhoff RH, Joenje H: No evidence for FANCF gene silencing in head-and-neck squamous cell carcinomas. Cell Oncol 2009, 31(1):53–56. Ameziane N, Chen F, Leemans CR, Brakenhoff RH, Joenje H: No evidence for FANCF gene silencing in head-and-neck squamous cell carcinomas. Cell Oncol 2009, 31(1):53–56.
13.
go back to reference Ghosh A, Maiti GP, Bandopadhyay MN, Chakraborty J, Biswas J, Roychoudhury S, Panda CK: Inactivation of 9q22.3 tumor suppressor genes predict outcome for patients with head and neck squamous cell carcinoma. Anticancer Res 2013, 33(3):1215–1220. Ghosh A, Maiti GP, Bandopadhyay MN, Chakraborty J, Biswas J, Roychoudhury S, Panda CK: Inactivation of 9q22.3 tumor suppressor genes predict outcome for patients with head and neck squamous cell carcinoma. Anticancer Res 2013, 33(3):1215–1220.
14.
go back to reference Califano J, van der Riet P, Westra W, Nawroz H, Clayman G, Piantadosi S, Corio R, Lee D, Greenberg B, Koch W, Sidransky D: Genetic progression model for head and neck cancer: implications for field cancerization. Cancer Res 1996, 56(11):2488–2492. Califano J, van der Riet P, Westra W, Nawroz H, Clayman G, Piantadosi S, Corio R, Lee D, Greenberg B, Koch W, Sidransky D: Genetic progression model for head and neck cancer: implications for field cancerization. Cancer Res 1996, 56(11):2488–2492.
15.
go back to reference van Zeeburg HJ, Snijders PJ, Wu T, Gluckman E, Soulier J, Surralles J, Castella M, van der Wal JE, Wennerberg J, Califano J, Velleuer E, Dietrich R, Ebell W, Bloemena E, Joenje H, Leemans CR, Brakenhoff RH: Clinical and molecular characteristics of squamous cell carcinomas from Fanconi anemia patients. J Natl Cancer Inst 2008, 100(22):1649–1653. 10.1093/jnci/djn366CrossRef van Zeeburg HJ, Snijders PJ, Wu T, Gluckman E, Soulier J, Surralles J, Castella M, van der Wal JE, Wennerberg J, Califano J, Velleuer E, Dietrich R, Ebell W, Bloemena E, Joenje H, Leemans CR, Brakenhoff RH: Clinical and molecular characteristics of squamous cell carcinomas from Fanconi anemia patients. J Natl Cancer Inst 2008, 100(22):1649–1653. 10.1093/jnci/djn366CrossRef
16.
go back to reference Radoi L, Paget-Bailly S, Cyr D, Papadopoulos A, Guida F, Schmaus A, Cénée S, Menvielle G, Carton M, Lapôtre-Ledoux B, Delafosse P, Stücker I, Luce D: Tobacco smoking, alcohol drinking and risk of oral cavity cancer by subsite: results of a French population-based case–control study, the ICARE study. Eur J Cancer Prev 2013, 22(3):268–276. 10.1097/CEJ.0b013e3283592cceCrossRef Radoi L, Paget-Bailly S, Cyr D, Papadopoulos A, Guida F, Schmaus A, Cénée S, Menvielle G, Carton M, Lapôtre-Ledoux B, Delafosse P, Stücker I, Luce D: Tobacco smoking, alcohol drinking and risk of oral cavity cancer by subsite: results of a French population-based case–control study, the ICARE study. Eur J Cancer Prev 2013, 22(3):268–276. 10.1097/CEJ.0b013e3283592cceCrossRef
17.
go back to reference Kutler DI, Wreesmann VB, Goberdhan A, Ben-Porat L, Satagopan J, Ngai I, Huvos AG, Giampietro P, Levran O, Pujara K, Diotti R, Carlson D, Huryn LA, Auerbach AD, Singh B: Human papillomavirus DNA and p53 polymorphisms in squamous cell carcinomas from Fanconi anemia patients. J Natl Cancer Inst 2003, 95(22):1718–1721. 10.1093/jnci/djg091CrossRef Kutler DI, Wreesmann VB, Goberdhan A, Ben-Porat L, Satagopan J, Ngai I, Huvos AG, Giampietro P, Levran O, Pujara K, Diotti R, Carlson D, Huryn LA, Auerbach AD, Singh B: Human papillomavirus DNA and p53 polymorphisms in squamous cell carcinomas from Fanconi anemia patients. J Natl Cancer Inst 2003, 95(22):1718–1721. 10.1093/jnci/djg091CrossRef
18.
go back to reference Alter BP, Giri N, Savage SA, Quint WG, de Koning MN, Schiffman M: Squamous cell carcinomas in patients with Fanconi anemia and dyskeratosis congenita: a search for human papillomavirus. Int J Cancer 2013, 133(6):1513–1515. 10.1002/ijc.28157CrossRef Alter BP, Giri N, Savage SA, Quint WG, de Koning MN, Schiffman M: Squamous cell carcinomas in patients with Fanconi anemia and dyskeratosis congenita: a search for human papillomavirus. Int J Cancer 2013, 133(6):1513–1515. 10.1002/ijc.28157CrossRef
19.
go back to reference Langevin F, Crossan GP, Rosado IV, Arends MJ, Patel KJ: Fancd2 counteracts the toxic effects of naturally produced aldehydes in mice. Nature 2011, 475(7354):53–58. 10.1038/nature10192CrossRef Langevin F, Crossan GP, Rosado IV, Arends MJ, Patel KJ: Fancd2 counteracts the toxic effects of naturally produced aldehydes in mice. Nature 2011, 475(7354):53–58. 10.1038/nature10192CrossRef
20.
go back to reference Hira A, Yabe H, Yoshida K, Okuno Y, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Nakamura J, Kojima S, Ogawa S, Matsuo K, Takata M, Yabe M: Variant ALDH2 is associated with accelerated progression of bone marrow failure in Japanese Fanconi anemia patients. Blood 2013, 122(18):3206–3209. 10.1182/blood-2013-06-507962CrossRef Hira A, Yabe H, Yoshida K, Okuno Y, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Nakamura J, Kojima S, Ogawa S, Matsuo K, Takata M, Yabe M: Variant ALDH2 is associated with accelerated progression of bone marrow failure in Japanese Fanconi anemia patients. Blood 2013, 122(18):3206–3209. 10.1182/blood-2013-06-507962CrossRef
21.
go back to reference Marttila E, Uittamo J, Rusanen P, Lindqvist C, Salaspuro M, Rautemaa R: Acetaldehyde production and microbial colonization in oral squamous cell carcinoma and oral lichenoid disease. Oral Surg Oral Med Oral Pathol Oral Radiol 2013, 116(1):61–68. 10.1016/j.oooo.2013.02.009CrossRef Marttila E, Uittamo J, Rusanen P, Lindqvist C, Salaspuro M, Rautemaa R: Acetaldehyde production and microbial colonization in oral squamous cell carcinoma and oral lichenoid disease. Oral Surg Oral Med Oral Pathol Oral Radiol 2013, 116(1):61–68. 10.1016/j.oooo.2013.02.009CrossRef
22.
go back to reference Uittamo J, Nieminen MT, Kaihovaara P, Bowyer P, Salaspuro M, Rautemaa R: Xylitol inhibits carcinogenic acetaldehyde production by Candida species. Int J Cancer 2011, 129(8):2038–2041. 10.1002/ijc.25844CrossRef Uittamo J, Nieminen MT, Kaihovaara P, Bowyer P, Salaspuro M, Rautemaa R: Xylitol inhibits carcinogenic acetaldehyde production by Candida species. Int J Cancer 2011, 129(8):2038–2041. 10.1002/ijc.25844CrossRef
Metadata
Title
Fanconi anemia: young patients at high risk for squamous cell carcinoma
Authors
Eunike Velleuer
Ralf Dietrich
Publication date
01-12-2014
Publisher
Springer Berlin Heidelberg
Published in
Molecular and Cellular Pediatrics / Issue 1/2014
Electronic ISSN: 2194-7791
DOI
https://doi.org/10.1186/s40348-014-0009-8

Other articles of this Issue 1/2014

Molecular and Cellular Pediatrics 1/2014 Go to the issue