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Open Access 01-12-2014 | Mini review

Matrix metalloproteinases and epileptogenesis

Author: Chrysanthy Ikonomidou

Published in: Molecular and Cellular Pediatrics | Issue 1/2014

Abstract

Matrix metalloproteinases are vital drivers of synaptic remodeling in health and disease. It is suggested that at early stages of epileptogenesis, inhibition of matrix metalloproteinases may help ameliorate cell death, aberrant network rewiring, and neuroinflammation and prevent development of epilepsy.

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Goldberg EM, Coulter DA: Mechanisms of epileptogenesis: a convergence on neural circuit dysfunction. Nat Rev Neurosci 2013, 14: 337–349. 10.1038/nrn3482CrossRef

Soleman S, Filipov MA, Dityatev A, Fawcett JW: Targeting the neural extracellular matrix in neurological disorders. Neuroscience 2013, 253: 194–213. 10.1016/j.neuroscience.2013.08.050CrossRef

Yong VW: Metalloproteinases: mediators of pathology and regeneration in the CNS. Nat Rev Neurosci 2005, 6: 931–944. 10.1038/nrn1807CrossRef

Rosenberg GA: Matrix metalloproteinases and their multiple roles in neurodegenerative diseases. Lancet Neurol 2009, 8: 205–216. 10.1016/S1474-4422(09)70016-XCrossRef

Ethel IM, Ethel DW: Matrix metalloproteinases in brain development and remodeling: synaptic functions and targets. J Neurosci Res 2007, 85: 2813–2823. 10.1002/jnr.21273CrossRef

Huntley GW: Synaptic circuit remodeling by matrix metalloproteinases in health and disease. Nat Rev Neurosci 2012, 13: 743–754. 10.1038/nrn3320CrossRef

Gu Z, Kaul M, Yan B, Kridel SJ, Cui J, Strongin A, Smith JW, Liddington RC, Lipton SA: S-nitrosylation of matrix metalloproteinases: signaling pathway to neuronal cell death. Science 2002, 297: 1186–1190. 10.1126/science.1073634CrossRef

Wilczynski GM, Konopacki FA, Wilczek E, Lasiecka Z, Gorlewicz A, Michaluk P, Wawrzyniak M, Malinowska M, Okulski P, Kolodziej LR, Konopka W, Duniec K, Mioduszewska B, Nikolaev E, Walczak A, Owczarek D, Gorecki DC, Zuschratter W, Ottersen OP, Kaczmarek L: Important role of matrix metalloproteinase-9 in epileptogenesis. J Cell Biol 2008, 10180: 1021–1035. 10.1083/jcb.200708213CrossRef

Yan Y, Hill YW, Rosenberg GA: Multiple roles of metalloproteinases in neurological disorders. Prog Mol Biol 2011, 99: 241–263.

10.

Rosenberg GA: Neurological diseases in relation to the blood-brain barrier. J Cereb Blood Flow Metab 2012, 32: 1139–1151. 10.1038/jcbfm.2011.197CrossRef

11.

Sifringer M, Stefovska V, Zentner I, Hansen B, Stepulak A, Knaute C, Marzahn J, Ikonomidou C: The role of matrix metalloproteinases in infant traumatic brain injury. Neurobiol Dis 2007, 25: 526–535. 10.1016/j.nbd.2006.10.019CrossRef

12.

Hoehna Y, Uckermann O, Luksch H, Stefovska V, Marzahn J, Theil M, Gorkiewicz T, Gawlak M, Wilczynski GM, Kaczmarek L, Ikonomidou C: Matrix metalloproteinase 9 regulates cell death following pilocarpine-induced seizures in the developing brain. Neurobiol Dis 2012, 48: 339–347. 10.1016/j.nbd.2012.06.023CrossRef

13.

Nagy V, Bozdagi O, Matynia A, Balcerzyk M, Okulski P, Dzwonek J, Costa RM, Silva AJ, Kaczmarek L, Huntley GW: Matrix metalloproteinase-9 is required for hippocampal late-phase long-term potentiation and memory. J Neurosci 2006, 26: 1923–1934. 10.1523/JNEUROSCI.4359-05.2006CrossRef

14.

Okulski P, Jay TM, Jaworski J, Duniec K, Dzwonek J, Konopacki FA, Wilczynski GM, Sánchez-Capelo A, Mallet J, Kaczmarek L: TIMP-1 abolishes MMP-9-dependent long-lasting long-term potentiation in the prefrontal cortex. Biol Psychiatry 2007, 62: 359–362. 10.1016/j.biopsych.2006.09.012CrossRef

15.

Bozdagi O, Nagy V, Kwei KT, Huntley GW: In vivo roles for matrix metalloproteinase-9 in mature hippocampal synaptic physiology and plasticity. J Neurophysiol 2007, 98: 334–344. 10.1152/jn.00202.2007CrossRef

16.

Tian L, Stefanidakis M, Ning L, Van Lint P, Nyman-Huttunen H, Libert C, Itohara S, Mishina M, Rauvala H, Gahmberg CG: Activation of NMDA receptors promotes dendritic spine development through MMP-mediated ICAM-5 cleavage. J Cell Biol 2007, 178: 687–700. 10.1083/jcb.200612097CrossRef

17.

Konopacki FA, Rylski M, Wilczek E, Amborska R, Detka D, Kaczmarek L, Wilczynski GM: Synaptic localization of seizure-induced matrix metalloproteinase-9 mRNA. Neuroscience 2007, 150: 31–39. 10.1016/j.neuroscience.2007.08.026CrossRef

18.

Papadia S, Hardingham GE: The dichotomy of NMDA receptor signaling. Neuroscientist 2007, 13: 572–579. 10.1177/1073858407305833CrossRef

19.

Schoknecht K, Shalev H: Blood-brain barrier dysfunction in brain diseases: clinical experience. Epilepsia 2012, 6: 7–13. 10.1111/j.1528-1167.2012.03697.xCrossRef

20.

Suenaga N, Ichiyama T, Kubota M, Isumi H, Tohyama J, Furukawa S: Roles of matrix metalloproteinase-9 and tissue inhibitors of metalloproteinases 1 in acute encephalopathy following prolonged febrile seizures. J Neurol Sci 2008, 266: 126–130. 10.1016/j.jns.2007.09.011CrossRef

21.

Mizoguchi H, Yamada K: Roles of matrix metalloproteinases and their targets in epileptogenesis and seizures. Clin Psychopharmacol Neurosci 2013, 11: 45–52. 10.9758/cpn.2013.11.2.45CrossRef

22.

Deng X, He G, Liu J, Luo F, Peng X, Tang S, Gao Z, Lin Q, Keller JM, Yang T, Keller ET: Recent advances in bone-targeted therapies of metastatic prostate cancer. Cancer Treat Rev 2014, 40: 730–738. 10.1016/j.ctrv.2014.04.003CrossRef

23.

Stellas D, Patsavoudi E: Inhibiting matrix metalloproteinases, an old story with new potentials for cancer treatment. Anticancer Agents Med Chem 2012, 12: 707–717. 10.2174/187152012802650246CrossRef

Title: Matrix metalloproteinases and epileptogenesis
Author: Chrysanthy Ikonomidou
Publication date: 01-12-2014
Publisher: Springer Berlin Heidelberg
Published in: Molecular and Cellular Pediatrics / Issue 1/2014
Electronic ISSN: 2194-7791
DOI: https://doi.org/10.1186/s40348-014-0006-y

At a glance: The STEP trials

Springer Medicine

Matrix metalloproteinases and epileptogenesis

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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