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Molecular and Cellular Pediatrics

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Open Access 01-12-2014 | Mini review

Are microRNAs suitable biomarkers of immunity to tuberculosis?

Authors: Bianca Ueberberg, Malte Kohns, Ertan Mayatepek, Marc Jacobsen

Published in: Molecular and Cellular Pediatrics | Issue 1/2014

Abstract

Background

MicroRNAs (miRNAs) are crucial regulators of human immunity e.g. against Mycobacterium tuberculosis. Against the background of still alarming high mortality of tuberculosis effective biomarkers to improve diagnosis of M. tuberculosis infection and successful treatment are of major importance.

Conclusions

This review summarizes recent surrogate tissue studies for identification of miRNA biomarker candidates in human tuberculosis with a special focus on reproducibility and conformance. In addition we provide assistance for the design of biomarker studies to circumvent major pitfalls.

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Title: Are microRNAs suitable biomarkers of immunity to tuberculosis?
Authors: Bianca Ueberberg
Malte Kohns
Ertan Mayatepek
Marc Jacobsen
Publication date: 01-12-2014
Publisher: Springer Berlin Heidelberg
Published in: Molecular and Cellular Pediatrics / Issue 1/2014
Electronic ISSN: 2194-7791
DOI: https://doi.org/10.1186/s40348-014-0008-9

At a glance: The STEP trials

Springer Medicine

Are microRNAs suitable biomarkers of immunity to tuberculosis?

Abstract

Background

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Conclusions

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